Prevalence and factors associated with renal impairment in HIV‐infected patients, ANRS C03 Aquitaine Cohort, France
Objectives The aims of the present study were to estimate the prevalence of renal impairment (RI) among HIV‐infected adult patients and to investigate the associated factors. Methods A cross‐sectional survey was conducted in a French hospital‐based cohort. Clearance of creatinine (CC) was calculated...
Gespeichert in:
| Veröffentlicht in: | HIV medicine 2010-05, Vol.11 (5), p.308-317 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 317 |
|---|---|
| container_issue | 5 |
| container_start_page | 308 |
| container_title | HIV medicine |
| container_volume | 11 |
| creator | Déti, EK Thiébaut, R Bonnet, F Lawson‐Ayayi, S Dupon, M Neau, D Pellegrin, JL Malvy, D Tchamgoué, S Dabis, F Morlat, P |
| description | Objectives
The aims of the present study were to estimate the prevalence of renal impairment (RI) among HIV‐infected adult patients and to investigate the associated factors.
Methods
A cross‐sectional survey was conducted in a French hospital‐based cohort. Clearance of creatinine (CC) was calculated using the Cockcroft–Gault formula. Four stages of RI were defined: mild (60–90 mL/min), moderate (30–60), severe (15–30) and end stage ( |
| doi_str_mv | 10.1111/j.1468-1293.2009.00780.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_745613278</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733119616</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4490-252e240ed2c9eca12659532f79095a2dab3d7e76f590c30fbbe787eaf68d64a13</originalsourceid><addsrcrecordid>eNqNkctu1TAQhiMEohd4BeQdmyaM7cSOJTZHRy2tVAHitrXmOBPVR7mc2gltdzwCz9gnwekp3cJsZqT5_pnFl2WMQ8FTvdsWvFR1zoWRhQAwBYCuobh9lh0-LZ4_zGUulBIH2VGMWwCupYGX2UHKgKgADrP5c6Cf2NHgiOHQsBbdNIbIMMbReZyoYTd-umKBBuyY73foQ0_DxPzAzi9-3P_67YeW3MLtcPJpE0_Y6uOXr2wNkq2uZz-hH4itx6sxTCfsLGB69Sp70WIX6fVjP86-n51-W5_nl58-XKxXl7krSwO5qASJEqgRzpBDLlRlKilabcBUKBrcyEaTVm1lwEloNxvStSZsVd2oErk8zt7u7-7CeD1TnGzvo6Ouw4HGOVpdVopLoet_k1JybhRXiaz3pAtjjIFauwu-x3BnOdjFjt3aRYJdJNjFjn2wY29T9M3jk3nTU_MU_KsjAe_3wI3v6O6_D9tkIg3yDyvdngM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733119616</pqid></control><display><type>article</type><title>Prevalence and factors associated with renal impairment in HIV‐infected patients, ANRS C03 Aquitaine Cohort, France</title><source>MEDLINE</source><source>IngentaConnect Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Free Content</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Déti, EK ; Thiébaut, R ; Bonnet, F ; Lawson‐Ayayi, S ; Dupon, M ; Neau, D ; Pellegrin, JL ; Malvy, D ; Tchamgoué, S ; Dabis, F ; Morlat, P</creator><creatorcontrib>Déti, EK ; Thiébaut, R ; Bonnet, F ; Lawson‐Ayayi, S ; Dupon, M ; Neau, D ; Pellegrin, JL ; Malvy, D ; Tchamgoué, S ; Dabis, F ; Morlat, P ; Groupe d'Epidémiologie Clinique du SIDA en Aquitaine ; for the Groupe d'Epidémiologie Clinique du SIDA en Aquitaine (GECSA)</creatorcontrib><description><![CDATA[Objectives
The aims of the present study were to estimate the prevalence of renal impairment (RI) among HIV‐infected adult patients and to investigate the associated factors.
Methods
A cross‐sectional survey was conducted in a French hospital‐based cohort. Clearance of creatinine (CC) was calculated using the Cockcroft–Gault formula. Four stages of RI were defined: mild (60–90 mL/min), moderate (30–60), severe (15–30) and end stage (<15). Logistic regression models were used to investigate factors associated with RI.
Results
The male/female ratio of the 2588 patients enrolled was 3:1 and the median age was 42 years. At the time of assessment of CC, the median CD4 count was 430 cells/μL and HIV plasma viral load (VL) was<50 copies/mL in 60%. The overall prevalence of RI was 39.0%: 34.2% mild, 4.4% moderate, 0.3% severe and 0.2% end‐stage. Mild RI was associated with female gender [odds ratio (OR)=3.3: 95% CI 2.6–4.3)], age >50 years (OR=9.8: 7.4–13.0) and 40–50 years (OR=1.9: 1.5–2.4), body mass index (BMI) <22 kg/m2 (OR=3.3: 2.7–4.3) and tenofovir exposure (OR=1.4: 1.0–1.9 for <1 year and OR=1.5: 1.2–2.0 for >1 year). Advanced RI (CC <60 mL/min) was associated with age >50 years (OR=5.6: 2.9–10.9) and 40–50 years (OR=2.2: 1.1–1.4), BMI <22 kg/m2 (OR=1.5: 1.0–2.4), hypertension (OR=2.5: 1.4–2.5) and indinavir (IDV) exposure >1 year (OR=2.3: 1.5–3.6).
Conclusion
This survey confirms the high prevalence of RI in HIV‐infected patients and indicates the importance of the investigation of renal function especially in women, older patients, those with a low BMI or treated with tenofovir or IDV.]]></description><identifier>ISSN: 1464-2662</identifier><identifier>EISSN: 1468-1293</identifier><identifier>DOI: 10.1111/j.1468-1293.2009.00780.x</identifier><identifier>PMID: 20002500</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adenine - adverse effects ; Adenine - analogs & derivatives ; Adult ; Age ; Anti-HIV Agents - adverse effects ; Body Mass Index ; CD4 antigen ; CD4 Lymphocyte Count ; Creatinine ; Creatinine - blood ; Epidemiologic Methods ; Female ; France - epidemiology ; HIV infection ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV Infections - epidemiology ; Human immunodeficiency virus ; Humans ; Hypertension ; Hypertension - epidemiology ; Indinavir ; Indinavir - adverse effects ; kidney ; Kidney - drug effects ; Kidney Function Tests ; Male ; Middle Aged ; Organophosphonates - adverse effects ; Regression analysis ; Renal function ; renal impairment ; Renal Insufficiency - epidemiology ; Renal Insufficiency - etiology ; Tenofovir</subject><ispartof>HIV medicine, 2010-05, Vol.11 (5), p.308-317</ispartof><rights>2009 British HIV Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4490-252e240ed2c9eca12659532f79095a2dab3d7e76f590c30fbbe787eaf68d64a13</citedby><cites>FETCH-LOGICAL-c4490-252e240ed2c9eca12659532f79095a2dab3d7e76f590c30fbbe787eaf68d64a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1468-1293.2009.00780.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1468-1293.2009.00780.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20002500$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Déti, EK</creatorcontrib><creatorcontrib>Thiébaut, R</creatorcontrib><creatorcontrib>Bonnet, F</creatorcontrib><creatorcontrib>Lawson‐Ayayi, S</creatorcontrib><creatorcontrib>Dupon, M</creatorcontrib><creatorcontrib>Neau, D</creatorcontrib><creatorcontrib>Pellegrin, JL</creatorcontrib><creatorcontrib>Malvy, D</creatorcontrib><creatorcontrib>Tchamgoué, S</creatorcontrib><creatorcontrib>Dabis, F</creatorcontrib><creatorcontrib>Morlat, P</creatorcontrib><creatorcontrib>Groupe d'Epidémiologie Clinique du SIDA en Aquitaine</creatorcontrib><creatorcontrib>for the Groupe d'Epidémiologie Clinique du SIDA en Aquitaine (GECSA)</creatorcontrib><title>Prevalence and factors associated with renal impairment in HIV‐infected patients, ANRS C03 Aquitaine Cohort, France</title><title>HIV medicine</title><addtitle>HIV Med</addtitle><description><![CDATA[Objectives
The aims of the present study were to estimate the prevalence of renal impairment (RI) among HIV‐infected adult patients and to investigate the associated factors.
Methods
A cross‐sectional survey was conducted in a French hospital‐based cohort. Clearance of creatinine (CC) was calculated using the Cockcroft–Gault formula. Four stages of RI were defined: mild (60–90 mL/min), moderate (30–60), severe (15–30) and end stage (<15). Logistic regression models were used to investigate factors associated with RI.
Results
The male/female ratio of the 2588 patients enrolled was 3:1 and the median age was 42 years. At the time of assessment of CC, the median CD4 count was 430 cells/μL and HIV plasma viral load (VL) was<50 copies/mL in 60%. The overall prevalence of RI was 39.0%: 34.2% mild, 4.4% moderate, 0.3% severe and 0.2% end‐stage. Mild RI was associated with female gender [odds ratio (OR)=3.3: 95% CI 2.6–4.3)], age >50 years (OR=9.8: 7.4–13.0) and 40–50 years (OR=1.9: 1.5–2.4), body mass index (BMI) <22 kg/m2 (OR=3.3: 2.7–4.3) and tenofovir exposure (OR=1.4: 1.0–1.9 for <1 year and OR=1.5: 1.2–2.0 for >1 year). Advanced RI (CC <60 mL/min) was associated with age >50 years (OR=5.6: 2.9–10.9) and 40–50 years (OR=2.2: 1.1–1.4), BMI <22 kg/m2 (OR=1.5: 1.0–2.4), hypertension (OR=2.5: 1.4–2.5) and indinavir (IDV) exposure >1 year (OR=2.3: 1.5–3.6).
Conclusion
This survey confirms the high prevalence of RI in HIV‐infected patients and indicates the importance of the investigation of renal function especially in women, older patients, those with a low BMI or treated with tenofovir or IDV.]]></description><subject>Adenine - adverse effects</subject><subject>Adenine - analogs & derivatives</subject><subject>Adult</subject><subject>Age</subject><subject>Anti-HIV Agents - adverse effects</subject><subject>Body Mass Index</subject><subject>CD4 antigen</subject><subject>CD4 Lymphocyte Count</subject><subject>Creatinine</subject><subject>Creatinine - blood</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>France - epidemiology</subject><subject>HIV infection</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - epidemiology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - epidemiology</subject><subject>Indinavir</subject><subject>Indinavir - adverse effects</subject><subject>kidney</subject><subject>Kidney - drug effects</subject><subject>Kidney Function Tests</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Organophosphonates - adverse effects</subject><subject>Regression analysis</subject><subject>Renal function</subject><subject>renal impairment</subject><subject>Renal Insufficiency - epidemiology</subject><subject>Renal Insufficiency - etiology</subject><subject>Tenofovir</subject><issn>1464-2662</issn><issn>1468-1293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctu1TAQhiMEohd4BeQdmyaM7cSOJTZHRy2tVAHitrXmOBPVR7mc2gltdzwCz9gnwekp3cJsZqT5_pnFl2WMQ8FTvdsWvFR1zoWRhQAwBYCuobh9lh0-LZ4_zGUulBIH2VGMWwCupYGX2UHKgKgADrP5c6Cf2NHgiOHQsBbdNIbIMMbReZyoYTd-umKBBuyY73foQ0_DxPzAzi9-3P_67YeW3MLtcPJpE0_Y6uOXr2wNkq2uZz-hH4itx6sxTCfsLGB69Sp70WIX6fVjP86-n51-W5_nl58-XKxXl7krSwO5qASJEqgRzpBDLlRlKilabcBUKBrcyEaTVm1lwEloNxvStSZsVd2oErk8zt7u7-7CeD1TnGzvo6Ouw4HGOVpdVopLoet_k1JybhRXiaz3pAtjjIFauwu-x3BnOdjFjt3aRYJdJNjFjn2wY29T9M3jk3nTU_MU_KsjAe_3wI3v6O6_D9tkIg3yDyvdngM</recordid><startdate>201005</startdate><enddate>201005</enddate><creator>Déti, EK</creator><creator>Thiébaut, R</creator><creator>Bonnet, F</creator><creator>Lawson‐Ayayi, S</creator><creator>Dupon, M</creator><creator>Neau, D</creator><creator>Pellegrin, JL</creator><creator>Malvy, D</creator><creator>Tchamgoué, S</creator><creator>Dabis, F</creator><creator>Morlat, P</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>201005</creationdate><title>Prevalence and factors associated with renal impairment in HIV‐infected patients, ANRS C03 Aquitaine Cohort, France</title><author>Déti, EK ; Thiébaut, R ; Bonnet, F ; Lawson‐Ayayi, S ; Dupon, M ; Neau, D ; Pellegrin, JL ; Malvy, D ; Tchamgoué, S ; Dabis, F ; Morlat, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4490-252e240ed2c9eca12659532f79095a2dab3d7e76f590c30fbbe787eaf68d64a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adenine - adverse effects</topic><topic>Adenine - analogs & derivatives</topic><topic>Adult</topic><topic>Age</topic><topic>Anti-HIV Agents - adverse effects</topic><topic>Body Mass Index</topic><topic>CD4 antigen</topic><topic>CD4 Lymphocyte Count</topic><topic>Creatinine</topic><topic>Creatinine - blood</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>France - epidemiology</topic><topic>HIV infection</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - epidemiology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - epidemiology</topic><topic>Indinavir</topic><topic>Indinavir - adverse effects</topic><topic>kidney</topic><topic>Kidney - drug effects</topic><topic>Kidney Function Tests</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Organophosphonates - adverse effects</topic><topic>Regression analysis</topic><topic>Renal function</topic><topic>renal impairment</topic><topic>Renal Insufficiency - epidemiology</topic><topic>Renal Insufficiency - etiology</topic><topic>Tenofovir</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Déti, EK</creatorcontrib><creatorcontrib>Thiébaut, R</creatorcontrib><creatorcontrib>Bonnet, F</creatorcontrib><creatorcontrib>Lawson‐Ayayi, S</creatorcontrib><creatorcontrib>Dupon, M</creatorcontrib><creatorcontrib>Neau, D</creatorcontrib><creatorcontrib>Pellegrin, JL</creatorcontrib><creatorcontrib>Malvy, D</creatorcontrib><creatorcontrib>Tchamgoué, S</creatorcontrib><creatorcontrib>Dabis, F</creatorcontrib><creatorcontrib>Morlat, P</creatorcontrib><creatorcontrib>Groupe d'Epidémiologie Clinique du SIDA en Aquitaine</creatorcontrib><creatorcontrib>for the Groupe d'Epidémiologie Clinique du SIDA en Aquitaine (GECSA)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>HIV medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Déti, EK</au><au>Thiébaut, R</au><au>Bonnet, F</au><au>Lawson‐Ayayi, S</au><au>Dupon, M</au><au>Neau, D</au><au>Pellegrin, JL</au><au>Malvy, D</au><au>Tchamgoué, S</au><au>Dabis, F</au><au>Morlat, P</au><aucorp>Groupe d'Epidémiologie Clinique du SIDA en Aquitaine</aucorp><aucorp>for the Groupe d'Epidémiologie Clinique du SIDA en Aquitaine (GECSA)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and factors associated with renal impairment in HIV‐infected patients, ANRS C03 Aquitaine Cohort, France</atitle><jtitle>HIV medicine</jtitle><addtitle>HIV Med</addtitle><date>2010-05</date><risdate>2010</risdate><volume>11</volume><issue>5</issue><spage>308</spage><epage>317</epage><pages>308-317</pages><issn>1464-2662</issn><eissn>1468-1293</eissn><abstract><![CDATA[Objectives
The aims of the present study were to estimate the prevalence of renal impairment (RI) among HIV‐infected adult patients and to investigate the associated factors.
Methods
A cross‐sectional survey was conducted in a French hospital‐based cohort. Clearance of creatinine (CC) was calculated using the Cockcroft–Gault formula. Four stages of RI were defined: mild (60–90 mL/min), moderate (30–60), severe (15–30) and end stage (<15). Logistic regression models were used to investigate factors associated with RI.
Results
The male/female ratio of the 2588 patients enrolled was 3:1 and the median age was 42 years. At the time of assessment of CC, the median CD4 count was 430 cells/μL and HIV plasma viral load (VL) was<50 copies/mL in 60%. The overall prevalence of RI was 39.0%: 34.2% mild, 4.4% moderate, 0.3% severe and 0.2% end‐stage. Mild RI was associated with female gender [odds ratio (OR)=3.3: 95% CI 2.6–4.3)], age >50 years (OR=9.8: 7.4–13.0) and 40–50 years (OR=1.9: 1.5–2.4), body mass index (BMI) <22 kg/m2 (OR=3.3: 2.7–4.3) and tenofovir exposure (OR=1.4: 1.0–1.9 for <1 year and OR=1.5: 1.2–2.0 for >1 year). Advanced RI (CC <60 mL/min) was associated with age >50 years (OR=5.6: 2.9–10.9) and 40–50 years (OR=2.2: 1.1–1.4), BMI <22 kg/m2 (OR=1.5: 1.0–2.4), hypertension (OR=2.5: 1.4–2.5) and indinavir (IDV) exposure >1 year (OR=2.3: 1.5–3.6).
Conclusion
This survey confirms the high prevalence of RI in HIV‐infected patients and indicates the importance of the investigation of renal function especially in women, older patients, those with a low BMI or treated with tenofovir or IDV.]]></abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20002500</pmid><doi>10.1111/j.1468-1293.2009.00780.x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1464-2662 |
| ispartof | HIV medicine, 2010-05, Vol.11 (5), p.308-317 |
| issn | 1464-2662 1468-1293 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_745613278 |
| source | MEDLINE; IngentaConnect Open Access Journals; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals |
| subjects | Adenine - adverse effects Adenine - analogs & derivatives Adult Age Anti-HIV Agents - adverse effects Body Mass Index CD4 antigen CD4 Lymphocyte Count Creatinine Creatinine - blood Epidemiologic Methods Female France - epidemiology HIV infection HIV Infections - complications HIV Infections - drug therapy HIV Infections - epidemiology Human immunodeficiency virus Humans Hypertension Hypertension - epidemiology Indinavir Indinavir - adverse effects kidney Kidney - drug effects Kidney Function Tests Male Middle Aged Organophosphonates - adverse effects Regression analysis Renal function renal impairment Renal Insufficiency - epidemiology Renal Insufficiency - etiology Tenofovir |
| title | Prevalence and factors associated with renal impairment in HIV‐infected patients, ANRS C03 Aquitaine Cohort, France |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T03%3A44%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevalence%20and%20factors%20associated%20with%20renal%20impairment%20in%20HIV%E2%80%90infected%20patients,%20ANRS%20C03%20Aquitaine%20Cohort,%20France&rft.jtitle=HIV%20medicine&rft.au=D%C3%A9ti,%20EK&rft.aucorp=Groupe%20d'Epid%C3%A9miologie%20Clinique%20du%20SIDA%20en%20Aquitaine&rft.date=2010-05&rft.volume=11&rft.issue=5&rft.spage=308&rft.epage=317&rft.pages=308-317&rft.issn=1464-2662&rft.eissn=1468-1293&rft_id=info:doi/10.1111/j.1468-1293.2009.00780.x&rft_dat=%3Cproquest_cross%3E733119616%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733119616&rft_id=info:pmid/20002500&rfr_iscdi=true |