Comparison of risk factors and work-up in young and middle-aged patients with TIA and ischaemic stroke
Background: The transient ischaemic attack (TIA) is accepted as a subtype of resolved ischaemic stroke. In that case, the risk factor profiles as well as the work‐up results of TIA and stroke patients should be similar in both groups. Given that such data are limited, we compared the risk factor pr...
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| Veröffentlicht in: | European journal of neurology 2010-04, Vol.17 (4), p.567-571 |
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| creator | Telman, G. Sprecher, E. Namestnikov, O. Kouperberg, E. |
| description | Background: The transient ischaemic attack (TIA) is accepted as a subtype of resolved ischaemic stroke. In that case, the risk factor profiles as well as the work‐up results of TIA and stroke patients should be similar in both groups. Given that such data are limited, we compared the risk factor profiles and work‐up results in young and middle‐aged patients with TIA and ischaemic stroke.
Patients and methods: Data on 167 TIA patients and 489 stroke patients aged ≤60 were compared for risk factor profiles, work‐up results, and pre‐ and post‐event treatment regimens.
Results: The only difference found between the groups in the distribution of vascular risk factors was a significantly higher prevalence of diabetes in the stroke group (P = 0.02). There were no differences found between the two groups in the distributions of carotid and aortic plaques, carotid stenoses and occlusion, homocysteine levels, or frequencies of patient foramen ovale by echocardiography. The levels of cholesterol and triglycerides, as well as abnormal brain CT, were higher in the stroke group, both before and after adjustment. There was no difference found in any compared parameter of treatment between the TIA and the stroke patients.
Conclusions: The risk factor profiles and the work‐up results are similar between the TIA and the stroke patients. These findings highlight the etiologic homogeneity of both conditions; therefore, justify their uniform management. In addition, low yield of CT in TIA patients was found, questioning thus the routine use of CT in work‐up of TIA. |
| doi_str_mv | 10.1111/j.1468-1331.2009.02857.x |
| format | Article |
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Patients and methods: Data on 167 TIA patients and 489 stroke patients aged ≤60 were compared for risk factor profiles, work‐up results, and pre‐ and post‐event treatment regimens.
Results: The only difference found between the groups in the distribution of vascular risk factors was a significantly higher prevalence of diabetes in the stroke group (P = 0.02). There were no differences found between the two groups in the distributions of carotid and aortic plaques, carotid stenoses and occlusion, homocysteine levels, or frequencies of patient foramen ovale by echocardiography. The levels of cholesterol and triglycerides, as well as abnormal brain CT, were higher in the stroke group, both before and after adjustment. There was no difference found in any compared parameter of treatment between the TIA and the stroke patients.
Conclusions: The risk factor profiles and the work‐up results are similar between the TIA and the stroke patients. These findings highlight the etiologic homogeneity of both conditions; therefore, justify their uniform management. In addition, low yield of CT in TIA patients was found, questioning thus the routine use of CT in work‐up of TIA.</description><identifier>ISSN: 1351-5101</identifier><identifier>EISSN: 1468-1331</identifier><identifier>DOI: 10.1111/j.1468-1331.2009.02857.x</identifier><identifier>PMID: 19922452</identifier><identifier>CODEN: EJNEFL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Age Factors ; Brain - diagnostic imaging ; Brain Ischemia - diagnostic imaging ; Brain Ischemia - drug therapy ; Brain Ischemia - epidemiology ; Brain Ischemia - metabolism ; Diabetes Mellitus - epidemiology ; Female ; Health risk assessment ; Humans ; Ischemic Attack, Transient - diagnostic imaging ; Ischemic Attack, Transient - drug therapy ; Ischemic Attack, Transient - epidemiology ; Ischemic Attack, Transient - metabolism ; Male ; Middle age ; Middle Aged ; Prevalence ; Risk Factors ; Stroke ; Stroke - diagnostic imaging ; Stroke - drug therapy ; Stroke - epidemiology ; Stroke - metabolism ; TIA ; Tomography, X-Ray Computed ; Treatment Outcome ; work-up</subject><ispartof>European journal of neurology, 2010-04, Vol.17 (4), p.567-571</ispartof><rights>2009 The Author(s). Journal compilation © 2009 EFNS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4667-903df0494e6fcd9d2343abd7940f6a018f45fe4ce7595e0a08a23c3b9d1b8c273</citedby><cites>FETCH-LOGICAL-c4667-903df0494e6fcd9d2343abd7940f6a018f45fe4ce7595e0a08a23c3b9d1b8c273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1468-1331.2009.02857.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1468-1331.2009.02857.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19922452$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Telman, G.</creatorcontrib><creatorcontrib>Sprecher, E.</creatorcontrib><creatorcontrib>Namestnikov, O.</creatorcontrib><creatorcontrib>Kouperberg, E.</creatorcontrib><title>Comparison of risk factors and work-up in young and middle-aged patients with TIA and ischaemic stroke</title><title>European journal of neurology</title><addtitle>Eur J Neurol</addtitle><description>Background: The transient ischaemic attack (TIA) is accepted as a subtype of resolved ischaemic stroke. In that case, the risk factor profiles as well as the work‐up results of TIA and stroke patients should be similar in both groups. Given that such data are limited, we compared the risk factor profiles and work‐up results in young and middle‐aged patients with TIA and ischaemic stroke.
Patients and methods: Data on 167 TIA patients and 489 stroke patients aged ≤60 were compared for risk factor profiles, work‐up results, and pre‐ and post‐event treatment regimens.
Results: The only difference found between the groups in the distribution of vascular risk factors was a significantly higher prevalence of diabetes in the stroke group (P = 0.02). There were no differences found between the two groups in the distributions of carotid and aortic plaques, carotid stenoses and occlusion, homocysteine levels, or frequencies of patient foramen ovale by echocardiography. The levels of cholesterol and triglycerides, as well as abnormal brain CT, were higher in the stroke group, both before and after adjustment. There was no difference found in any compared parameter of treatment between the TIA and the stroke patients.
Conclusions: The risk factor profiles and the work‐up results are similar between the TIA and the stroke patients. These findings highlight the etiologic homogeneity of both conditions; therefore, justify their uniform management. In addition, low yield of CT in TIA patients was found, questioning thus the routine use of CT in work‐up of TIA.</description><subject>Age Factors</subject><subject>Brain - diagnostic imaging</subject><subject>Brain Ischemia - diagnostic imaging</subject><subject>Brain Ischemia - drug therapy</subject><subject>Brain Ischemia - epidemiology</subject><subject>Brain Ischemia - metabolism</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Ischemic Attack, Transient - diagnostic imaging</subject><subject>Ischemic Attack, Transient - drug therapy</subject><subject>Ischemic Attack, Transient - epidemiology</subject><subject>Ischemic Attack, Transient - metabolism</subject><subject>Male</subject><subject>Middle age</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Stroke</subject><subject>Stroke - diagnostic imaging</subject><subject>Stroke - drug therapy</subject><subject>Stroke - epidemiology</subject><subject>Stroke - metabolism</subject><subject>TIA</subject><subject>Tomography, X-Ray Computed</subject><subject>Treatment Outcome</subject><subject>work-up</subject><issn>1351-5101</issn><issn>1468-1331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v0zAYhyMEYmPwFZAlDpwSXv-JHR84jFLKpKkIaQhulhs7m9sk7uxEbb89TlsNiQv44lf283tfW0-WIQwFTuvDusCMVzmmFBcEQBZAqlIU-2fZ5dPF81TTEuclBnyRvYpxDQBEEHiZXWApCWElucyame-2Orjoe-QblIoNanQ9-BCR7g3a-bDJxy1yPTr4sb8_HnbOmNbm-t4atNWDs_0Q0c4ND-ju5vpIuFg_aNu5GsUh-I19nb1odBvtm_N-lf34Mr-bfc1vvy1uZte3ec04F7kEahpgklne1EYaQhnVKyMkg4ZrwFXDysay2opSlhY0VJrQmq6kwauqJoJeZe9PfbfBP442DqpLT7Ftq3vrx6gEKzkGWuF_k5RSkAJ4It_9Ra79GPr0DYUrwBy4ECRR1Ymqg48x2EZtg-t0OCgMapKm1mpyoyY3apKmjtLUPkXfngeMq86aP8GzpQR8PAE719rDfzdW8-V8qlI-P-VdHOz-Ka_DRnFBRal-LhdqIZe_Pn1eYPWd_gbm8bNY</recordid><startdate>201004</startdate><enddate>201004</enddate><creator>Telman, G.</creator><creator>Sprecher, E.</creator><creator>Namestnikov, O.</creator><creator>Kouperberg, E.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201004</creationdate><title>Comparison of risk factors and work-up in young and middle-aged patients with TIA and ischaemic stroke</title><author>Telman, G. ; Sprecher, E. ; Namestnikov, O. ; Kouperberg, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4667-903df0494e6fcd9d2343abd7940f6a018f45fe4ce7595e0a08a23c3b9d1b8c273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Age Factors</topic><topic>Brain - diagnostic imaging</topic><topic>Brain Ischemia - diagnostic imaging</topic><topic>Brain Ischemia - drug therapy</topic><topic>Brain Ischemia - epidemiology</topic><topic>Brain Ischemia - metabolism</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Ischemic Attack, Transient - diagnostic imaging</topic><topic>Ischemic Attack, Transient - drug therapy</topic><topic>Ischemic Attack, Transient - epidemiology</topic><topic>Ischemic Attack, Transient - metabolism</topic><topic>Male</topic><topic>Middle age</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Stroke</topic><topic>Stroke - diagnostic imaging</topic><topic>Stroke - drug therapy</topic><topic>Stroke - epidemiology</topic><topic>Stroke - metabolism</topic><topic>TIA</topic><topic>Tomography, X-Ray Computed</topic><topic>Treatment Outcome</topic><topic>work-up</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Telman, G.</creatorcontrib><creatorcontrib>Sprecher, E.</creatorcontrib><creatorcontrib>Namestnikov, O.</creatorcontrib><creatorcontrib>Kouperberg, E.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Telman, G.</au><au>Sprecher, E.</au><au>Namestnikov, O.</au><au>Kouperberg, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of risk factors and work-up in young and middle-aged patients with TIA and ischaemic stroke</atitle><jtitle>European journal of neurology</jtitle><addtitle>Eur J Neurol</addtitle><date>2010-04</date><risdate>2010</risdate><volume>17</volume><issue>4</issue><spage>567</spage><epage>571</epage><pages>567-571</pages><issn>1351-5101</issn><eissn>1468-1331</eissn><coden>EJNEFL</coden><abstract>Background: The transient ischaemic attack (TIA) is accepted as a subtype of resolved ischaemic stroke. In that case, the risk factor profiles as well as the work‐up results of TIA and stroke patients should be similar in both groups. Given that such data are limited, we compared the risk factor profiles and work‐up results in young and middle‐aged patients with TIA and ischaemic stroke.
Patients and methods: Data on 167 TIA patients and 489 stroke patients aged ≤60 were compared for risk factor profiles, work‐up results, and pre‐ and post‐event treatment regimens.
Results: The only difference found between the groups in the distribution of vascular risk factors was a significantly higher prevalence of diabetes in the stroke group (P = 0.02). There were no differences found between the two groups in the distributions of carotid and aortic plaques, carotid stenoses and occlusion, homocysteine levels, or frequencies of patient foramen ovale by echocardiography. The levels of cholesterol and triglycerides, as well as abnormal brain CT, were higher in the stroke group, both before and after adjustment. There was no difference found in any compared parameter of treatment between the TIA and the stroke patients.
Conclusions: The risk factor profiles and the work‐up results are similar between the TIA and the stroke patients. These findings highlight the etiologic homogeneity of both conditions; therefore, justify their uniform management. In addition, low yield of CT in TIA patients was found, questioning thus the routine use of CT in work‐up of TIA.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19922452</pmid><doi>10.1111/j.1468-1331.2009.02857.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Age Factors Brain - diagnostic imaging Brain Ischemia - diagnostic imaging Brain Ischemia - drug therapy Brain Ischemia - epidemiology Brain Ischemia - metabolism Diabetes Mellitus - epidemiology Female Health risk assessment Humans Ischemic Attack, Transient - diagnostic imaging Ischemic Attack, Transient - drug therapy Ischemic Attack, Transient - epidemiology Ischemic Attack, Transient - metabolism Male Middle age Middle Aged Prevalence Risk Factors Stroke Stroke - diagnostic imaging Stroke - drug therapy Stroke - epidemiology Stroke - metabolism TIA Tomography, X-Ray Computed Treatment Outcome work-up |
| title | Comparison of risk factors and work-up in young and middle-aged patients with TIA and ischaemic stroke |
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