Involvement of peptidylarginine deiminase-mediated post-translational citrullination in pathogenesis of sporadic Creutzfeldt-Jakob disease

Peptidylarginine deiminases (PADs)-mediated post-translational citrullination processes play key roles in protein functions and structural stability through the conversion of arginine to citrulline in the presence of excessive calcium concentrations. In brain, PAD2 is abundantly expressed and can be...

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Veröffentlicht in:	Acta neuropathologica 2010-02, Vol.119 (2), p.199-210
Hauptverfasser:	Jang, Byungki, Jin, Jae-Kwang, Jeon, Yong-Chul, Cho, Han Jeong, Ishigami, Akihito, Choi, Kyung-Chan, Carp, Richard I., Maruyama, Naoki, Kim, Yong-Sun, Choi, Eun-Kyoung
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer's disease Astrocytes - metabolism Binding sites Biomarkers - metabolism Blotting, Western Citrulline - metabolism Creutzfeldt-Jakob disease Creutzfeldt-Jakob Syndrome - metabolism Creutzfeldt-Jakob Syndrome - pathology Enzyme Activation - physiology Female Fluorescent Antibody Technique Frontal Lobe - metabolism Frontal Lobe - pathology Humans Hydrolases - metabolism Immunohistochemistry Kinases Life sciences Localization Male Medicine Medicine & Public Health Middle Aged Neurodegeneration Neurosciences Original Paper Pathogenesis Pathology Protein Processing, Post-Translational - physiology Protein-Arginine Deiminases Proteins Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Up-Regulation
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