Aging Research: Current and Future
The key events that lead to organismic senescence appear to occur in cells that have been genetically pro-grammed to arrest their own proliferation. After arrest, a variety of subcellular events occur, among the more important of which are the accumulation of waste product pigments, an increase in t...
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| Veröffentlicht in: | Journal of investigative dermatology 1979-07, Vol.73 (1), p.2-7 |
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| container_title | Journal of investigative dermatology |
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| creator | Strehler, Bernard L. |
| description | The key events that lead to organismic senescence appear to occur in cells that have been genetically pro-grammed to arrest their own proliferation. After arrest, a variety of subcellular events occur, among the more important of which are the accumulation of waste product pigments, an increase in the fraction of inactive enzymes, and (probably of central importance) the loss of key genes, specifically those that code for rRNA. An understanding of the senescence of the epidermis and dermis would almost certainly provide answers to related problems in those organ systems whose sudden or slow failure leads to individual death. |
| doi_str_mv | 10.1111/1523-1747.ep12532751 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0022-202X |
| ispartof | Journal of investigative dermatology, 1979-07, Vol.73 (1), p.2-7 |
| issn | 0022-202X 1523-1747 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74553772 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Aging Animals Cell Division Cell Physiological Phenomena Enzymes - physiology Genes Genetic Code Humans Longevity Skin Physiological Phenomena |
| title | Aging Research: Current and Future |
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