Early pregnancy factor is immunosuppressive
IMMUNOSUPPRESSION during pregnancy has important consequences not only with respect to the recognition of the antigenically dissimilar embryo 1 but also in terms of susceptibility to viral or tumour assaults 2,3 . We have recently described an early pregnancy factor (EPF) detectable within 24 h of m...
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| Veröffentlicht in: | Nature (London) 1979-04, Vol.278 (5705), p.649-651 |
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| container_title | Nature (London) |
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| creator | NOONAN, F. P. HALLIDAY, W. J. MORTON, H. CLUNIE, G. J. A. |
| description | IMMUNOSUPPRESSION during pregnancy has important consequences not only with respect to the recognition of the antigenically dissimilar embryo
1
but also in terms of susceptibility to viral or tumour assaults
2,3
. We have recently described an early pregnancy factor (EPF) detectable within 24 h of mating and have postulated that this protein is responsible for depression of lymphocyte activity during pregnancy
4–6
, Immunosuppressive properties have been attributed to other proteins detectable during pregnancy. These include pregnancy-associated macroglobulin
7,8
α
-fetoprotein
9
and human chorionic gonadotropin (HCG)
10,11
. One characteristic these substances have in common, but in which they differ from EPF, is that they are not present, or not detectable, in the early stages of pregnancy. Recently the immunosuppressive activity of HCG has been disputed by several workers working with highly purified material
12,13
. We have now shown that EPF inhibits the expression of an immune response
in vivo
. |
| doi_str_mv | 10.1038/278649a0 |
| format | Article |
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1
but also in terms of susceptibility to viral or tumour assaults
2,3
. We have recently described an early pregnancy factor (EPF) detectable within 24 h of mating and have postulated that this protein is responsible for depression of lymphocyte activity during pregnancy
4–6
, Immunosuppressive properties have been attributed to other proteins detectable during pregnancy. These include pregnancy-associated macroglobulin
7,8
α
-fetoprotein
9
and human chorionic gonadotropin (HCG)
10,11
. One characteristic these substances have in common, but in which they differ from EPF, is that they are not present, or not detectable, in the early stages of pregnancy. Recently the immunosuppressive activity of HCG has been disputed by several workers working with highly purified material
12,13
. We have now shown that EPF inhibits the expression of an immune response
in vivo
.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/278649a0</identifier><identifier>PMID: 313010</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Female ; Humanities and Social Sciences ; Humans ; Immunity, Cellular ; Immunization, Passive ; Immunosuppression ; letter ; Mice ; multidisciplinary ; Pregnancy ; Rosette Formation ; Science ; Sheep ; Skin Tests ; Species Specificity ; T-Lymphocytes - immunology</subject><ispartof>Nature (London), 1979-04, Vol.278 (5705), p.649-651</ispartof><rights>Springer Nature Limited 1979</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-ed1af74d9527206d01800dd2cf7d9cf4f41630b33e9d50e8502442676d87f0243</citedby><cites>FETCH-LOGICAL-c377t-ed1af74d9527206d01800dd2cf7d9cf4f41630b33e9d50e8502442676d87f0243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/278649a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/278649a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/313010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NOONAN, F. P.</creatorcontrib><creatorcontrib>HALLIDAY, W. J.</creatorcontrib><creatorcontrib>MORTON, H.</creatorcontrib><creatorcontrib>CLUNIE, G. J. A.</creatorcontrib><title>Early pregnancy factor is immunosuppressive</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>IMMUNOSUPPRESSION during pregnancy has important consequences not only with respect to the recognition of the antigenically dissimilar embryo
1
but also in terms of susceptibility to viral or tumour assaults
2,3
. We have recently described an early pregnancy factor (EPF) detectable within 24 h of mating and have postulated that this protein is responsible for depression of lymphocyte activity during pregnancy
4–6
, Immunosuppressive properties have been attributed to other proteins detectable during pregnancy. These include pregnancy-associated macroglobulin
7,8
α
-fetoprotein
9
and human chorionic gonadotropin (HCG)
10,11
. One characteristic these substances have in common, but in which they differ from EPF, is that they are not present, or not detectable, in the early stages of pregnancy. Recently the immunosuppressive activity of HCG has been disputed by several workers working with highly purified material
12,13
. We have now shown that EPF inhibits the expression of an immune response
in vivo
.</description><subject>Animals</subject><subject>Female</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Immunity, Cellular</subject><subject>Immunization, Passive</subject><subject>Immunosuppression</subject><subject>letter</subject><subject>Mice</subject><subject>multidisciplinary</subject><subject>Pregnancy</subject><subject>Rosette Formation</subject><subject>Science</subject><subject>Sheep</subject><subject>Skin Tests</subject><subject>Species Specificity</subject><subject>T-Lymphocytes - immunology</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkEtLAzEUhYP4qlXwB7iYlSgyevOYJLOUUh9QcKPrkOZRpszLpCPMvzcy1Y2re-D7OHAPQpcY7jFQ-UCE5KzUcIBmmAmeMy7FIZoBEJmDpPwUncW4BYACC3aCjimmgGGG7pY61GPWB7dpdWvGzGuz60JWxaxqmqHt4tAnGGP15c7Rkdd1dBf7O0cfT8v3xUu-ent-XTyuckOF2OXOYu0Fs2VBBAFuAUsAa4nxwpbGM88wp7Cm1JW2ACcLIIwRLriVwqdM5-h66u1D9zm4uFNNFY2ra926bohKsIIBIyKJN5NoQhdjcF71oWp0GBUG9TOL-p0lqVf7zmHdOPsnTjskfDvhmEC7cUFtuyG06cv_Vd_Az2gn</recordid><startdate>19790412</startdate><enddate>19790412</enddate><creator>NOONAN, F. P.</creator><creator>HALLIDAY, W. J.</creator><creator>MORTON, H.</creator><creator>CLUNIE, G. J. A.</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19790412</creationdate><title>Early pregnancy factor is immunosuppressive</title><author>NOONAN, F. P. ; HALLIDAY, W. J. ; MORTON, H. ; CLUNIE, G. J. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-ed1af74d9527206d01800dd2cf7d9cf4f41630b33e9d50e8502442676d87f0243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animals</topic><topic>Female</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Immunity, Cellular</topic><topic>Immunization, Passive</topic><topic>Immunosuppression</topic><topic>letter</topic><topic>Mice</topic><topic>multidisciplinary</topic><topic>Pregnancy</topic><topic>Rosette Formation</topic><topic>Science</topic><topic>Sheep</topic><topic>Skin Tests</topic><topic>Species Specificity</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NOONAN, F. P.</creatorcontrib><creatorcontrib>HALLIDAY, W. J.</creatorcontrib><creatorcontrib>MORTON, H.</creatorcontrib><creatorcontrib>CLUNIE, G. J. A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NOONAN, F. P.</au><au>HALLIDAY, W. J.</au><au>MORTON, H.</au><au>CLUNIE, G. J. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early pregnancy factor is immunosuppressive</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1979-04-12</date><risdate>1979</risdate><volume>278</volume><issue>5705</issue><spage>649</spage><epage>651</epage><pages>649-651</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>IMMUNOSUPPRESSION during pregnancy has important consequences not only with respect to the recognition of the antigenically dissimilar embryo
1
but also in terms of susceptibility to viral or tumour assaults
2,3
. We have recently described an early pregnancy factor (EPF) detectable within 24 h of mating and have postulated that this protein is responsible for depression of lymphocyte activity during pregnancy
4–6
, Immunosuppressive properties have been attributed to other proteins detectable during pregnancy. These include pregnancy-associated macroglobulin
7,8
α
-fetoprotein
9
and human chorionic gonadotropin (HCG)
10,11
. One characteristic these substances have in common, but in which they differ from EPF, is that they are not present, or not detectable, in the early stages of pregnancy. Recently the immunosuppressive activity of HCG has been disputed by several workers working with highly purified material
12,13
. We have now shown that EPF inhibits the expression of an immune response
in vivo
.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>313010</pmid><doi>10.1038/278649a0</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1979-04, Vol.278 (5705), p.649-651 |
| issn | 0028-0836 1476-4687 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals; Nature Journals Online |
| subjects | Animals Female Humanities and Social Sciences Humans Immunity, Cellular Immunization, Passive Immunosuppression letter Mice multidisciplinary Pregnancy Rosette Formation Science Sheep Skin Tests Species Specificity T-Lymphocytes - immunology |
| title | Early pregnancy factor is immunosuppressive |
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