Effect of some drugs on cerebral energy state during and after hypoxia and complete or incomplete ischemia
The effect of caffeine, nicergoline and medibazine was evaluated in the brain of beagle dogs during various experimental conditions of cerebral damage (hypoxia, hypoxia plus incomplete ischemia, hypoxia plus complete ischemia), and during post-hypoxic recovery and restoration of circulation. The beh...
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| Veröffentlicht in: | Biochemical pharmacology 1979, Vol.28 (3), p.435-439 |
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| container_end_page | 439 |
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| container_title | Biochemical pharmacology |
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| creator | Benzi, Gianni Arrigoni, Elena Pastoris, Ornella Villa, Roberto F. Dagani, Fiorenzo Marzatico, Fulvio Agnoli, Alessandro |
| description | The effect of caffeine, nicergoline and medibazine was evaluated in the brain of beagle dogs during various experimental conditions of cerebral damage (hypoxia, hypoxia plus incomplete ischemia, hypoxia plus complete ischemia), and during post-hypoxic recovery and restoration of circulation. The behavior of fuels (glycogen, glucose), of glycolytic pathway intermediates (glucose-6-phosphate, pyruvate) and end-product (lactate), as well as the pool of labile phosphates (ATP, ADP, AMP, creatine phosphate) and the energy charge potential were evaluated in the motor area of the cerebral cortex.
The drugs tested proved unable to improve the deranged brain metabolism and the energy charge potential under these various hypoxemic conditions. On the contrary, a certain pharmacological effect of nicergoline and medibazine could be observed both in the post-hypoxic recovery and in the recovery following hypoxia plus complete ischemia, caffeine being totally ineffective. As for the recovery subsequent to hypoxia plus incomplete ischemia, none of the drugs tested was able to trigger restoration. |
| doi_str_mv | 10.1016/0006-2952(79)90111-4 |
| format | Article |
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The drugs tested proved unable to improve the deranged brain metabolism and the energy charge potential under these various hypoxemic conditions. On the contrary, a certain pharmacological effect of nicergoline and medibazine could be observed both in the post-hypoxic recovery and in the recovery following hypoxia plus complete ischemia, caffeine being totally ineffective. As for the recovery subsequent to hypoxia plus incomplete ischemia, none of the drugs tested was able to trigger restoration.</description><identifier>ISSN: 0006-2952</identifier><identifier>EISSN: 1873-2968</identifier><identifier>DOI: 10.1016/0006-2952(79)90111-4</identifier><identifier>PMID: 426861</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Animals ; Benzhydryl Compounds - pharmacology ; Brain - drug effects ; Brain - metabolism ; Caffeine - pharmacology ; Dogs ; Energy Metabolism - drug effects ; Female ; Hypoxia - metabolism ; Ischemic Attack, Transient - metabolism ; Nicergoline - pharmacology ; Piperazines - pharmacology</subject><ispartof>Biochemical pharmacology, 1979, Vol.28 (3), p.435-439</ispartof><rights>1979</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-c1c09094354c6f437e8719af1950a6d8adf8df0a58e9481121593e0b5cd689553</citedby><cites>FETCH-LOGICAL-c356t-c1c09094354c6f437e8719af1950a6d8adf8df0a58e9481121593e0b5cd689553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-2952(79)90111-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/426861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Benzi, Gianni</creatorcontrib><creatorcontrib>Arrigoni, Elena</creatorcontrib><creatorcontrib>Pastoris, Ornella</creatorcontrib><creatorcontrib>Villa, Roberto F.</creatorcontrib><creatorcontrib>Dagani, Fiorenzo</creatorcontrib><creatorcontrib>Marzatico, Fulvio</creatorcontrib><creatorcontrib>Agnoli, Alessandro</creatorcontrib><title>Effect of some drugs on cerebral energy state during and after hypoxia and complete or incomplete ischemia</title><title>Biochemical pharmacology</title><addtitle>Biochem Pharmacol</addtitle><description>The effect of caffeine, nicergoline and medibazine was evaluated in the brain of beagle dogs during various experimental conditions of cerebral damage (hypoxia, hypoxia plus incomplete ischemia, hypoxia plus complete ischemia), and during post-hypoxic recovery and restoration of circulation. The behavior of fuels (glycogen, glucose), of glycolytic pathway intermediates (glucose-6-phosphate, pyruvate) and end-product (lactate), as well as the pool of labile phosphates (ATP, ADP, AMP, creatine phosphate) and the energy charge potential were evaluated in the motor area of the cerebral cortex.
The drugs tested proved unable to improve the deranged brain metabolism and the energy charge potential under these various hypoxemic conditions. On the contrary, a certain pharmacological effect of nicergoline and medibazine could be observed both in the post-hypoxic recovery and in the recovery following hypoxia plus complete ischemia, caffeine being totally ineffective. As for the recovery subsequent to hypoxia plus incomplete ischemia, none of the drugs tested was able to trigger restoration.</description><subject>Animals</subject><subject>Benzhydryl Compounds - pharmacology</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Caffeine - pharmacology</subject><subject>Dogs</subject><subject>Energy Metabolism - drug effects</subject><subject>Female</subject><subject>Hypoxia - metabolism</subject><subject>Ischemic Attack, Transient - metabolism</subject><subject>Nicergoline - pharmacology</subject><subject>Piperazines - pharmacology</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPxCAUhYnxNT7-gQtWRhdVaIHCxsSY8ZGYuNE1YeAyYtoyQmucf2_rmFm6uo9z7gl8CJ1RckUJFdeEEFGUipcXtbpUhFJasB00o7KuxrWQu2i2tRyio5w_plEKeoD2WTk1M_Qx9x5sj6PHObaAXRqWGccOW0iwSKbB0EFarnHuTT_KQwrdEpvOYeN7SPh9vYrfwfxubGxXDYyumHDotlPI9h3aYE7QnjdNhtO_eoze7uevd4_F88vD093tc2ErLvrCUksUUazizArPqhpkTZXxVHFihJPGeek8MVyCYpLSknJVAVlw64RUnFfH6HyTu0rxc4Dc63Z8AjSN6SAOWdeMl5WQk5FtjDbFnBN4vUqhNWmtKdETYT3x0hM-XSv9S1iz8ezsL39YtOC2Rxuko3yzkWH841eApLMN0FlwIY2ktYvh__wfoDCKhQ</recordid><startdate>1979</startdate><enddate>1979</enddate><creator>Benzi, Gianni</creator><creator>Arrigoni, Elena</creator><creator>Pastoris, Ornella</creator><creator>Villa, Roberto F.</creator><creator>Dagani, Fiorenzo</creator><creator>Marzatico, Fulvio</creator><creator>Agnoli, Alessandro</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1979</creationdate><title>Effect of some drugs on cerebral energy state during and after hypoxia and complete or incomplete ischemia</title><author>Benzi, Gianni ; Arrigoni, Elena ; Pastoris, Ornella ; Villa, Roberto F. ; Dagani, Fiorenzo ; Marzatico, Fulvio ; Agnoli, Alessandro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-c1c09094354c6f437e8719af1950a6d8adf8df0a58e9481121593e0b5cd689553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animals</topic><topic>Benzhydryl Compounds - pharmacology</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Caffeine - pharmacology</topic><topic>Dogs</topic><topic>Energy Metabolism - drug effects</topic><topic>Female</topic><topic>Hypoxia - metabolism</topic><topic>Ischemic Attack, Transient - metabolism</topic><topic>Nicergoline - pharmacology</topic><topic>Piperazines - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Benzi, Gianni</creatorcontrib><creatorcontrib>Arrigoni, Elena</creatorcontrib><creatorcontrib>Pastoris, Ornella</creatorcontrib><creatorcontrib>Villa, Roberto F.</creatorcontrib><creatorcontrib>Dagani, Fiorenzo</creatorcontrib><creatorcontrib>Marzatico, Fulvio</creatorcontrib><creatorcontrib>Agnoli, Alessandro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benzi, Gianni</au><au>Arrigoni, Elena</au><au>Pastoris, Ornella</au><au>Villa, Roberto F.</au><au>Dagani, Fiorenzo</au><au>Marzatico, Fulvio</au><au>Agnoli, Alessandro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of some drugs on cerebral energy state during and after hypoxia and complete or incomplete ischemia</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>1979</date><risdate>1979</risdate><volume>28</volume><issue>3</issue><spage>435</spage><epage>439</epage><pages>435-439</pages><issn>0006-2952</issn><eissn>1873-2968</eissn><abstract>The effect of caffeine, nicergoline and medibazine was evaluated in the brain of beagle dogs during various experimental conditions of cerebral damage (hypoxia, hypoxia plus incomplete ischemia, hypoxia plus complete ischemia), and during post-hypoxic recovery and restoration of circulation. The behavior of fuels (glycogen, glucose), of glycolytic pathway intermediates (glucose-6-phosphate, pyruvate) and end-product (lactate), as well as the pool of labile phosphates (ATP, ADP, AMP, creatine phosphate) and the energy charge potential were evaluated in the motor area of the cerebral cortex.
The drugs tested proved unable to improve the deranged brain metabolism and the energy charge potential under these various hypoxemic conditions. On the contrary, a certain pharmacological effect of nicergoline and medibazine could be observed both in the post-hypoxic recovery and in the recovery following hypoxia plus complete ischemia, caffeine being totally ineffective. As for the recovery subsequent to hypoxia plus incomplete ischemia, none of the drugs tested was able to trigger restoration.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>426861</pmid><doi>10.1016/0006-2952(79)90111-4</doi><tpages>5</tpages></addata></record> |
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| ispartof | Biochemical pharmacology, 1979, Vol.28 (3), p.435-439 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Benzhydryl Compounds - pharmacology Brain - drug effects Brain - metabolism Caffeine - pharmacology Dogs Energy Metabolism - drug effects Female Hypoxia - metabolism Ischemic Attack, Transient - metabolism Nicergoline - pharmacology Piperazines - pharmacology |
| title | Effect of some drugs on cerebral energy state during and after hypoxia and complete or incomplete ischemia |
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