3-Substituted pyrazole derivatives as inhibitors and inactivators of liver alcohol dehydrogenase

3-Substituted pyrazoles, HOCH2 (1), HOCH2CH2 (2), HOCH2CH2CH2 (3), ClCH2 (4), ClCH2CH2 (5), ClCH2CH2CH2 (6), and CH3CO (7), were synthesized and evaluated in vitro on horse liver alcohol dehydrogenase for their potential as inhibitors of ethanol metabolism. 1 to 6 bound to the enzyme-NAD+ complex wi...

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Veröffentlicht in:	Journal of medicinal chemistry 1979-04, Vol.22 (4), p.356-359
Hauptverfasser:	Fries, Richard W, Bohlken, David P, Plapp, Bryce V
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Oxidoreductases - antagonists & inhibitors Animals Horses In Vitro Techniques Liver - drug effects Liver - enzymology NAD - metabolism Pyrazoles - chemical synthesis Pyrazoles - pharmacology Spectrophotometry, Ultraviolet
Online-Zugang:	Volltext
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