Lack of pneumococcal carriage in the hospitalised elderly
Abstract There have been few surveys of Streptococcus pneumoniae and Neisseria meningitidis carriage in sick or frail elderly people who, with the very young, comprise the group who are at highest risk for pneumococcal disease. We studied pneumococcal carriage among participants in a pneumococcal im...
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| Veröffentlicht in: | Vaccine 2010-05, Vol.28 (23), p.3902-3904 |
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| creator | Ridda, I MacIntyre, C.R Lindley, R McIntyre, P.B Brown, M Oftadeh, S Sullivan, J Gilbert, G.L |
| description | Abstract There have been few surveys of Streptococcus pneumoniae and Neisseria meningitidis carriage in sick or frail elderly people who, with the very young, comprise the group who are at highest risk for pneumococcal disease. We studied pneumococcal carriage among participants in a pneumococcal immunisation study in the frail elderly. Methods Subjects aged ≥60 years were recruited from a large tertiary referral hospital in Sydney, Australia. Nose and throat swabs were collected at the time of enrolment and 12 months after immunisation. Results Before immunisation, only 1 of 315 participants was identified as a nasal carrier of S. pneumoniae ; another was identified as throat carrier of N. meningitidis . None of the participants examined after immunisation was carrying either S. pneumoniae or N. meningitidis. Conclusion The low rate of pneumococcal carriage in this population of hospitalised elderly patients was unexpected. The most likely reason is that long-term carriage is rare in this population and suggests that pneumococcal disease primarily follows recent acquisition of S. pneumoniae types not associated with carriage. |
| doi_str_mv | 10.1016/j.vaccine.2010.03.073 |
| format | Article |
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We studied pneumococcal carriage among participants in a pneumococcal immunisation study in the frail elderly. Methods Subjects aged ≥60 years were recruited from a large tertiary referral hospital in Sydney, Australia. Nose and throat swabs were collected at the time of enrolment and 12 months after immunisation. Results Before immunisation, only 1 of 315 participants was identified as a nasal carrier of S. pneumoniae ; another was identified as throat carrier of N. meningitidis . None of the participants examined after immunisation was carrying either S. pneumoniae or N. meningitidis. Conclusion The low rate of pneumococcal carriage in this population of hospitalised elderly patients was unexpected. The most likely reason is that long-term carriage is rare in this population and suggests that pneumococcal disease primarily follows recent acquisition of S. pneumoniae types not associated with carriage.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2010.03.073</identifier><identifier>PMID: 20398618</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Aged ; Allergy and Immunology ; Applied microbiology ; Australia ; Bacteriology ; Biological and medical sciences ; Carriage rate ; Carrier State - epidemiology ; Children & youth ; Frailty ; Fundamental and applied biological sciences. Psychology ; Geriatrics ; Humans ; Immunization ; Inpatients ; Meningitis ; Meningococcal Infections - epidemiology ; Microbiology ; Miscellaneous ; Mortality ; Neisseria meningitidis ; Neisseria meningitidis - isolation & purification ; Nose - microbiology ; Older people ; Pharynx - microbiology ; Pneumococcal Infections - epidemiology ; Pneumococcal Vaccines - administration & dosage ; Pneumococci ; Pneumonia ; Streptococcus pneumoniae - isolation & purification ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><ispartof>Vaccine, 2010-05, Vol.28 (23), p.3902-3904</ispartof><rights>Elsevier Ltd</rights><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited May 21, 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-d95bb854fd97c340409f4ffb0ca6a3086ad897f603a64cbbfd67b94ee20fe4513</citedby><cites>FETCH-LOGICAL-c509t-d95bb854fd97c340409f4ffb0ca6a3086ad897f603a64cbbfd67b94ee20fe4513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X10004731$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22865493$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20398618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ridda, I</creatorcontrib><creatorcontrib>MacIntyre, C.R</creatorcontrib><creatorcontrib>Lindley, R</creatorcontrib><creatorcontrib>McIntyre, P.B</creatorcontrib><creatorcontrib>Brown, M</creatorcontrib><creatorcontrib>Oftadeh, S</creatorcontrib><creatorcontrib>Sullivan, J</creatorcontrib><creatorcontrib>Gilbert, G.L</creatorcontrib><title>Lack of pneumococcal carriage in the hospitalised elderly</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Abstract There have been few surveys of Streptococcus pneumoniae and Neisseria meningitidis carriage in sick or frail elderly people who, with the very young, comprise the group who are at highest risk for pneumococcal disease. We studied pneumococcal carriage among participants in a pneumococcal immunisation study in the frail elderly. Methods Subjects aged ≥60 years were recruited from a large tertiary referral hospital in Sydney, Australia. Nose and throat swabs were collected at the time of enrolment and 12 months after immunisation. Results Before immunisation, only 1 of 315 participants was identified as a nasal carrier of S. pneumoniae ; another was identified as throat carrier of N. meningitidis . None of the participants examined after immunisation was carrying either S. pneumoniae or N. meningitidis. Conclusion The low rate of pneumococcal carriage in this population of hospitalised elderly patients was unexpected. The most likely reason is that long-term carriage is rare in this population and suggests that pneumococcal disease primarily follows recent acquisition of S. pneumoniae types not associated with carriage.</description><subject>Aged</subject><subject>Allergy and Immunology</subject><subject>Applied microbiology</subject><subject>Australia</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Carriage rate</subject><subject>Carrier State - epidemiology</subject><subject>Children & youth</subject><subject>Frailty</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Immunization</subject><subject>Inpatients</subject><subject>Meningitis</subject><subject>Meningococcal Infections - epidemiology</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Mortality</subject><subject>Neisseria meningitidis</subject><subject>Neisseria meningitidis - isolation & purification</subject><subject>Nose - microbiology</subject><subject>Older people</subject><subject>Pharynx - microbiology</subject><subject>Pneumococcal Infections - epidemiology</subject><subject>Pneumococcal Vaccines - administration & dosage</subject><subject>Pneumococci</subject><subject>Pneumonia</subject><subject>Streptococcus pneumoniae - isolation & purification</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkk-LFDEQxYMo7uzqR1AaRDz1WPnXSS4usrgqDHhQwVtIpytuZnu6x6R7Yb69aWZ0YS97ChS_epV6rwh5RWFNgTbvt-s7530ccM2g1ICvQfEnZEW14jWTVD8lK2CNqAWFX2fkPOctAEhOzXNyxoAb3VC9Imbj_G01hmo_4Lwb_ei96yvvUoruN1ZxqKYbrG7GvI-T62PGrsK-w9QfXpBnwfUZX57eC_Lz-tOPqy_15tvnr1cfN7WXYKa6M7JttRShM8pzAQJMECG04F3jOOjGddqo0AB3jfBtG7pGtUYgMggoJOUX5N1Rd5_GPzPmye5i9tj3bsBxzlYJocBIqR8ny3imNVvINw_I7TinoaxhqTCKG6Y0L5Q8Uj6NOScMdp_izqWDpWCXEOzWnkKwSwgWuC0hlL7XJ_W53WH3v-uf6wV4ewJcLnaH5AYf8z3HdCOFWYQujxwWf-8iJpt9xMFjFxP6yXZjfPQrHx4o-D4OsQy9xQPm-61tZhbs9-ViloOh5VaE4pT_BWoAuvg</recordid><startdate>20100521</startdate><enddate>20100521</enddate><creator>Ridda, I</creator><creator>MacIntyre, C.R</creator><creator>Lindley, R</creator><creator>McIntyre, P.B</creator><creator>Brown, M</creator><creator>Oftadeh, S</creator><creator>Sullivan, J</creator><creator>Gilbert, G.L</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20100521</creationdate><title>Lack of pneumococcal carriage in the hospitalised elderly</title><author>Ridda, I ; MacIntyre, C.R ; Lindley, R ; McIntyre, P.B ; Brown, M ; Oftadeh, S ; Sullivan, J ; Gilbert, G.L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-d95bb854fd97c340409f4ffb0ca6a3086ad897f603a64cbbfd67b94ee20fe4513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Allergy and Immunology</topic><topic>Applied microbiology</topic><topic>Australia</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Carriage rate</topic><topic>Carrier State - epidemiology</topic><topic>Children & youth</topic><topic>Frailty</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Immunization</topic><topic>Inpatients</topic><topic>Meningitis</topic><topic>Meningococcal Infections - epidemiology</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Mortality</topic><topic>Neisseria meningitidis</topic><topic>Neisseria meningitidis - isolation & purification</topic><topic>Nose - microbiology</topic><topic>Older people</topic><topic>Pharynx - microbiology</topic><topic>Pneumococcal Infections - epidemiology</topic><topic>Pneumococcal Vaccines - administration & dosage</topic><topic>Pneumococci</topic><topic>Pneumonia</topic><topic>Streptococcus pneumoniae - isolation & purification</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ridda, I</creatorcontrib><creatorcontrib>MacIntyre, C.R</creatorcontrib><creatorcontrib>Lindley, R</creatorcontrib><creatorcontrib>McIntyre, P.B</creatorcontrib><creatorcontrib>Brown, M</creatorcontrib><creatorcontrib>Oftadeh, S</creatorcontrib><creatorcontrib>Sullivan, J</creatorcontrib><creatorcontrib>Gilbert, G.L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ridda, I</au><au>MacIntyre, C.R</au><au>Lindley, R</au><au>McIntyre, P.B</au><au>Brown, M</au><au>Oftadeh, S</au><au>Sullivan, J</au><au>Gilbert, G.L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of pneumococcal carriage in the hospitalised elderly</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2010-05-21</date><risdate>2010</risdate><volume>28</volume><issue>23</issue><spage>3902</spage><epage>3904</epage><pages>3902-3904</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Abstract There have been few surveys of Streptococcus pneumoniae and Neisseria meningitidis carriage in sick or frail elderly people who, with the very young, comprise the group who are at highest risk for pneumococcal disease. We studied pneumococcal carriage among participants in a pneumococcal immunisation study in the frail elderly. Methods Subjects aged ≥60 years were recruited from a large tertiary referral hospital in Sydney, Australia. Nose and throat swabs were collected at the time of enrolment and 12 months after immunisation. Results Before immunisation, only 1 of 315 participants was identified as a nasal carrier of S. pneumoniae ; another was identified as throat carrier of N. meningitidis . None of the participants examined after immunisation was carrying either S. pneumoniae or N. meningitidis. Conclusion The low rate of pneumococcal carriage in this population of hospitalised elderly patients was unexpected. The most likely reason is that long-term carriage is rare in this population and suggests that pneumococcal disease primarily follows recent acquisition of S. pneumoniae types not associated with carriage.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>20398618</pmid><doi>10.1016/j.vaccine.2010.03.073</doi><tpages>3</tpages></addata></record> |
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| subjects | Aged Allergy and Immunology Applied microbiology Australia Bacteriology Biological and medical sciences Carriage rate Carrier State - epidemiology Children & youth Frailty Fundamental and applied biological sciences. Psychology Geriatrics Humans Immunization Inpatients Meningitis Meningococcal Infections - epidemiology Microbiology Miscellaneous Mortality Neisseria meningitidis Neisseria meningitidis - isolation & purification Nose - microbiology Older people Pharynx - microbiology Pneumococcal Infections - epidemiology Pneumococcal Vaccines - administration & dosage Pneumococci Pneumonia Streptococcus pneumoniae - isolation & purification Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | Lack of pneumococcal carriage in the hospitalised elderly |
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