Porcine reproductive and respiratory syndrome virus attachment is mediated by the N-terminal domain of the sialoadhesin receptor

Sialoadhesin (Sn) is an important receptor for viral attachment and internalization of porcine reproductive and respiratory syndrome virus (PRRSV) to porcine alveolar macrophages (PAM). To investigate whether the N-terminal domain of Sn is sufficient and/or necessary for PRRSV attachment, we constru...

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Veröffentlicht in:	Veterinary microbiology 2010-07, Vol.143 (2), p.371-378
Hauptverfasser:	An, Tong-Qing, Tian, Zhi-Jun, He, Yun-Xia, Xiao, Yan, Jiang, Yi-Feng, Peng, Jin-Mei, Zhou, Yan-Jun, Liu, Di, Tong, Guang-Zhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals binding capacity Binding domain binding sites biochemical mechanisms Biological and medical sciences cell adhesion cell lines Cells, Cultured Core Binding Factors Fundamental and applied biological sciences. Psychology Gene Deletion gene expression genes host-pathogen relationships immune system immunoglobulins in vitro studies infection macrophages Macrophages, Alveolar - physiology Macrophages, Alveolar - virology membrane glycoproteins Membrane Glycoproteins - physiology Microbiology Miscellaneous Models, Molecular mutation pathogenesis porcine reproductive and respiratory syndrome Porcine reproductive and respiratory syndrome virus Porcine reproductive and respiratory syndrome virus (PRRSV) Porcine respiratory and reproductive syndrome virus Porcine respiratory and reproductive syndrome virus - physiology Protein Binding Protein Conformation pulmonary alveoli Receptor receptors Receptors, Immunologic - physiology Sialic Acid Binding Ig-like Lectin 1 sialic acids Sialoadhesin sialoadhesin receptor Swine Virology Virus Attachment
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