Bone status in adolescents with type 1 diabetes
Aims The aim of the study was to investigate the potential negative impact of type 1 diabetes on bone status of adolescents. Bone status in adolescents with type 1 diabetes was assessed by means of quantitative ultrasound (QUS) and the influence of metabolic control and other disease-related and gro...
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| Veröffentlicht in: | Diabetologia 2010-08, Vol.53 (8), p.1754-1760 |
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| creator | Chobot, A. P. Haffke, A. Polanska, J. Halaba, Z. P. Deja, G. Jarosz-Chobot, P. Pluskiewicz, W. |
| description | Aims
The aim of the study was to investigate the potential negative impact of type 1 diabetes on bone status of adolescents. Bone status in adolescents with type 1 diabetes was assessed by means of quantitative ultrasound (QUS) and the influence of metabolic control and other disease-related and growth variables was analysed.
Methods
Group I consisted of 99 pubertal (Tanner ≥2) adolescents (49 female), aged 14.3 ± 2.5 years, diabetes duration 4.6 ± 2.3 years. Controls (group II) were 297 children, matched by sex and age, from a healthy population. The influence of glycated haemoglobin (current: HbA
1c
D; last year’s mean: HbA
1c
Y; whole duration mean: HbA
1c
T), diabetes duration, percentage of life with disease and daily insulin requirement (DIR) on amplitude dependent speed of sound (Ad-SoS) at distal phalanges was studied.
Results
In comparison to the control group, adolescents with type 1 diabetes presented significantly higher BMI SDS (0.82 [95% CI 0.54, 1.10] vs −0.06 [95% CI −0.16, 0.04]
p |
| doi_str_mv | 10.1007/s00125-010-1782-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_744703940</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2067086501</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-b64f851d26301c4f661d00a63cb42b195474a02c480a5b1aed1498edba7517ec3</originalsourceid><addsrcrecordid>eNqFkF1LwzAUhoMobk5_gDdSBPGq7pz0pGkvdfgFA28UvAtpmmpH186mRfbvzeh0IIhXSThP3rx5GDtFuEIAOXUAyEUICCHKhIewx8ZIkd8QT_bZeDMOMYlfR-zIuQUARILiQzbiQIJSgWM2vWlqG7hOd70LyjrQeVNZZ2zdueCz7N6Dbr2yAQZ5qTPbWXfMDgpdOXuyXSfs5e72efYQzp_uH2fX89CQFF2YxVQkAnMeR4CGijjGHEDHkcmIZ5gKkqSBG0pAiwy1zZHSxOaZlgKlNdGEXQ65q7b56K3r1LL0tapK17bpnZJEEqKU4H8yishnC_Tk-S9y0fRt7b-hBEeU0qvyEA6QaRvnWluoVVsudbtWCGpjXQ3WFWzO3rraVDjbBvfZ0uY_N741e-BiC2hndFW0ujal23E8lSLlief4wDk_qt9su2v49-tfRp6WTQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>521177186</pqid></control><display><type>article</type><title>Bone status in adolescents with type 1 diabetes</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Chobot, A. P. ; Haffke, A. ; Polanska, J. ; Halaba, Z. P. ; Deja, G. ; Jarosz-Chobot, P. ; Pluskiewicz, W.</creator><creatorcontrib>Chobot, A. P. ; Haffke, A. ; Polanska, J. ; Halaba, Z. P. ; Deja, G. ; Jarosz-Chobot, P. ; Pluskiewicz, W.</creatorcontrib><description>Aims
The aim of the study was to investigate the potential negative impact of type 1 diabetes on bone status of adolescents. Bone status in adolescents with type 1 diabetes was assessed by means of quantitative ultrasound (QUS) and the influence of metabolic control and other disease-related and growth variables was analysed.
Methods
Group I consisted of 99 pubertal (Tanner ≥2) adolescents (49 female), aged 14.3 ± 2.5 years, diabetes duration 4.6 ± 2.3 years. Controls (group II) were 297 children, matched by sex and age, from a healthy population. The influence of glycated haemoglobin (current: HbA
1c
D; last year’s mean: HbA
1c
Y; whole duration mean: HbA
1c
T), diabetes duration, percentage of life with disease and daily insulin requirement (DIR) on amplitude dependent speed of sound (Ad-SoS) at distal phalanges was studied.
Results
In comparison to the control group, adolescents with type 1 diabetes presented significantly higher BMI SDS (0.82 [95% CI 0.54, 1.10] vs −0.06 [95% CI −0.16, 0.04]
p
< 0.001) and lower Ad-SoS SDS (−0.34 [95% CI −0.57, −0.11] vs −0.03 [95% CI −0.15, 0.08],
p
< 0.05). No correlation between Ad-SoS SDS and sex, DIR or diabetes duration was observed. The lower Ad-SoS SDS reflects reduced bone status, and the reduction was significantly more marked in those patients whose HbA
1c
T was higher than 7.0% when compared with those whose HbA
1c
T was lower.
Conclusions
Bone status of adolescents with type 1 diabetes mellitus assessed with QUS differs from that of healthy peers and is dependent on long-term metabolic control.</description><identifier>ISSN: 0012-186X</identifier><identifier>EISSN: 1432-0428</identifier><identifier>DOI: 10.1007/s00125-010-1782-0</identifier><identifier>PMID: 20454951</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Analysis of Variance ; Biological and medical sciences ; Blood Glucose - metabolism ; Bone and Bones - diagnostic imaging ; Bone and Bones - metabolism ; Child ; Chromatography, High Pressure Liquid ; Chronic illnesses ; Diabetes ; Diabetes Mellitus, Type 1 - diagnostic imaging ; Diabetes Mellitus, Type 1 - metabolism ; Diabetes. Impaired glucose tolerance ; Disease ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Fractures ; Glycated Hemoglobin A - metabolism ; Human Physiology ; Humans ; Hypoglycemia ; Insulin ; Internal Medicine ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolism ; Patient Selection ; Patients ; Pediatrics ; Puberty - metabolism ; Statistics, Nonparametric ; Surveys and Questionnaires ; Teenagers ; Ultrasonic imaging ; Ultrasonography</subject><ispartof>Diabetologia, 2010-08, Vol.53 (8), p.1754-1760</ispartof><rights>Springer-Verlag 2010</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-b64f851d26301c4f661d00a63cb42b195474a02c480a5b1aed1498edba7517ec3</citedby><cites>FETCH-LOGICAL-c475t-b64f851d26301c4f661d00a63cb42b195474a02c480a5b1aed1498edba7517ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00125-010-1782-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00125-010-1782-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22975928$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20454951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chobot, A. P.</creatorcontrib><creatorcontrib>Haffke, A.</creatorcontrib><creatorcontrib>Polanska, J.</creatorcontrib><creatorcontrib>Halaba, Z. P.</creatorcontrib><creatorcontrib>Deja, G.</creatorcontrib><creatorcontrib>Jarosz-Chobot, P.</creatorcontrib><creatorcontrib>Pluskiewicz, W.</creatorcontrib><title>Bone status in adolescents with type 1 diabetes</title><title>Diabetologia</title><addtitle>Diabetologia</addtitle><addtitle>Diabetologia</addtitle><description>Aims
The aim of the study was to investigate the potential negative impact of type 1 diabetes on bone status of adolescents. Bone status in adolescents with type 1 diabetes was assessed by means of quantitative ultrasound (QUS) and the influence of metabolic control and other disease-related and growth variables was analysed.
Methods
Group I consisted of 99 pubertal (Tanner ≥2) adolescents (49 female), aged 14.3 ± 2.5 years, diabetes duration 4.6 ± 2.3 years. Controls (group II) were 297 children, matched by sex and age, from a healthy population. The influence of glycated haemoglobin (current: HbA
1c
D; last year’s mean: HbA
1c
Y; whole duration mean: HbA
1c
T), diabetes duration, percentage of life with disease and daily insulin requirement (DIR) on amplitude dependent speed of sound (Ad-SoS) at distal phalanges was studied.
Results
In comparison to the control group, adolescents with type 1 diabetes presented significantly higher BMI SDS (0.82 [95% CI 0.54, 1.10] vs −0.06 [95% CI −0.16, 0.04]
p
< 0.001) and lower Ad-SoS SDS (−0.34 [95% CI −0.57, −0.11] vs −0.03 [95% CI −0.15, 0.08],
p
< 0.05). No correlation between Ad-SoS SDS and sex, DIR or diabetes duration was observed. The lower Ad-SoS SDS reflects reduced bone status, and the reduction was significantly more marked in those patients whose HbA
1c
T was higher than 7.0% when compared with those whose HbA
1c
T was lower.
Conclusions
Bone status of adolescents with type 1 diabetes mellitus assessed with QUS differs from that of healthy peers and is dependent on long-term metabolic control.</description><subject>Adolescent</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>Bone and Bones - metabolism</subject><subject>Child</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Chronic illnesses</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 1 - diagnostic imaging</subject><subject>Diabetes Mellitus, Type 1 - metabolism</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Disease</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Fractures</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Hypoglycemia</subject><subject>Insulin</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Metabolism</subject><subject>Patient Selection</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Puberty - metabolism</subject><subject>Statistics, Nonparametric</subject><subject>Surveys and Questionnaires</subject><subject>Teenagers</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkF1LwzAUhoMobk5_gDdSBPGq7pz0pGkvdfgFA28UvAtpmmpH186mRfbvzeh0IIhXSThP3rx5GDtFuEIAOXUAyEUICCHKhIewx8ZIkd8QT_bZeDMOMYlfR-zIuQUARILiQzbiQIJSgWM2vWlqG7hOd70LyjrQeVNZZ2zdueCz7N6Dbr2yAQZ5qTPbWXfMDgpdOXuyXSfs5e72efYQzp_uH2fX89CQFF2YxVQkAnMeR4CGijjGHEDHkcmIZ5gKkqSBG0pAiwy1zZHSxOaZlgKlNdGEXQ65q7b56K3r1LL0tapK17bpnZJEEqKU4H8yishnC_Tk-S9y0fRt7b-hBEeU0qvyEA6QaRvnWluoVVsudbtWCGpjXQ3WFWzO3rraVDjbBvfZ0uY_N741e-BiC2hndFW0ujal23E8lSLlief4wDk_qt9su2v49-tfRp6WTQ</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Chobot, A. P.</creator><creator>Haffke, A.</creator><creator>Polanska, J.</creator><creator>Halaba, Z. P.</creator><creator>Deja, G.</creator><creator>Jarosz-Chobot, P.</creator><creator>Pluskiewicz, W.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>20100801</creationdate><title>Bone status in adolescents with type 1 diabetes</title><author>Chobot, A. P. ; Haffke, A. ; Polanska, J. ; Halaba, Z. P. ; Deja, G. ; Jarosz-Chobot, P. ; Pluskiewicz, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-b64f851d26301c4f661d00a63cb42b195474a02c480a5b1aed1498edba7517ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>Bone and Bones - metabolism</topic><topic>Child</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Chronic illnesses</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 1 - diagnostic imaging</topic><topic>Diabetes Mellitus, Type 1 - metabolism</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Disease</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Fractures</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Hypoglycemia</topic><topic>Insulin</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Metabolism</topic><topic>Patient Selection</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Puberty - metabolism</topic><topic>Statistics, Nonparametric</topic><topic>Surveys and Questionnaires</topic><topic>Teenagers</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chobot, A. P.</creatorcontrib><creatorcontrib>Haffke, A.</creatorcontrib><creatorcontrib>Polanska, J.</creatorcontrib><creatorcontrib>Halaba, Z. P.</creatorcontrib><creatorcontrib>Deja, G.</creatorcontrib><creatorcontrib>Jarosz-Chobot, P.</creatorcontrib><creatorcontrib>Pluskiewicz, W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Diabetologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chobot, A. P.</au><au>Haffke, A.</au><au>Polanska, J.</au><au>Halaba, Z. P.</au><au>Deja, G.</au><au>Jarosz-Chobot, P.</au><au>Pluskiewicz, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone status in adolescents with type 1 diabetes</atitle><jtitle>Diabetologia</jtitle><stitle>Diabetologia</stitle><addtitle>Diabetologia</addtitle><date>2010-08-01</date><risdate>2010</risdate><volume>53</volume><issue>8</issue><spage>1754</spage><epage>1760</epage><pages>1754-1760</pages><issn>0012-186X</issn><eissn>1432-0428</eissn><abstract>Aims
The aim of the study was to investigate the potential negative impact of type 1 diabetes on bone status of adolescents. Bone status in adolescents with type 1 diabetes was assessed by means of quantitative ultrasound (QUS) and the influence of metabolic control and other disease-related and growth variables was analysed.
Methods
Group I consisted of 99 pubertal (Tanner ≥2) adolescents (49 female), aged 14.3 ± 2.5 years, diabetes duration 4.6 ± 2.3 years. Controls (group II) were 297 children, matched by sex and age, from a healthy population. The influence of glycated haemoglobin (current: HbA
1c
D; last year’s mean: HbA
1c
Y; whole duration mean: HbA
1c
T), diabetes duration, percentage of life with disease and daily insulin requirement (DIR) on amplitude dependent speed of sound (Ad-SoS) at distal phalanges was studied.
Results
In comparison to the control group, adolescents with type 1 diabetes presented significantly higher BMI SDS (0.82 [95% CI 0.54, 1.10] vs −0.06 [95% CI −0.16, 0.04]
p
< 0.001) and lower Ad-SoS SDS (−0.34 [95% CI −0.57, −0.11] vs −0.03 [95% CI −0.15, 0.08],
p
< 0.05). No correlation between Ad-SoS SDS and sex, DIR or diabetes duration was observed. The lower Ad-SoS SDS reflects reduced bone status, and the reduction was significantly more marked in those patients whose HbA
1c
T was higher than 7.0% when compared with those whose HbA
1c
T was lower.
Conclusions
Bone status of adolescents with type 1 diabetes mellitus assessed with QUS differs from that of healthy peers and is dependent on long-term metabolic control.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>20454951</pmid><doi>10.1007/s00125-010-1782-0</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Diabetologia, 2010-08, Vol.53 (8), p.1754-1760 |
| issn | 0012-186X 1432-0428 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adolescent Analysis of Variance Biological and medical sciences Blood Glucose - metabolism Bone and Bones - diagnostic imaging Bone and Bones - metabolism Child Chromatography, High Pressure Liquid Chronic illnesses Diabetes Diabetes Mellitus, Type 1 - diagnostic imaging Diabetes Mellitus, Type 1 - metabolism Diabetes. Impaired glucose tolerance Disease Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Fractures Glycated Hemoglobin A - metabolism Human Physiology Humans Hypoglycemia Insulin Internal Medicine Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metabolism Patient Selection Patients Pediatrics Puberty - metabolism Statistics, Nonparametric Surveys and Questionnaires Teenagers Ultrasonic imaging Ultrasonography |
| title | Bone status in adolescents with type 1 diabetes |
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