Genotoxic Hazard and Cellular Stress in Pediatric Patients Treated for Psoriasis with the Goeckerman Regimen

: The Goeckerman regimen (GR) represents a local treatment of psoriasis and includes topical dermal application of crude coal tar (containing polycyclic aromatic hydrocarbons) and exposure to UV‐irradiation. The aim of the study was to evaluate contribution of GR to genotoxic risk and cellular stre...

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Veröffentlicht in:	Pediatric dermatology 2009-01, Vol.26 (1), p.23-27
Hauptverfasser:	Borska, Lenka, Andrys, Ctirad, Krejsek, Jan, Hamakova, Kvetoslava, Kremlacek, Jan, Ettler, Karel, Vellappally, Sajith, Vimal, Jacob, Fiala, Zdenek
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Adolescent Biological and medical sciences Child Chromosome Aberrations - chemically induced Coal Tar - administration & dosage Coal Tar - toxicity Combined Modality Therapy Czech Republic Dermatology Female General aspects HSP70 Heat-Shock Proteins - metabolism Humans Keratolytic Agents - administration & dosage Keratolytic Agents - toxicity Lymphocytes - metabolism Lymphocytes - pathology Male Medical sciences Psoriasis - drug therapy Psoriasis - epidemiology Psoriasis - radiotherapy Psoriasis. Parapsoriasis. Lichen Risk Factors Severity of Illness Index Stress, Physiological - drug effects Stress, Physiological - radiation effects Ultraviolet Rays - adverse effects
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