Viral encephalitis of tilapia larvae: Primary characterization of a novel herpes-like virus
Abstract We report here an outbreak of an acute disease that caused high mortality rate in laboratory-reared tilapia larvae. The disease was initially observed in inbred gynogenetic line of blue tilapia larvae ( Oreochromis aureus ) and could be transmitted to larvae of other tilapia species. Based...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 2010-04, Vol.399 (2), p.239-247 |
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| container_title | Virology (New York, N.Y.) |
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| creator | Shlapobersky, Mark Sinyakov, Michael S Katzenellenbogen, Mark Sarid, Ronit Don, Jeremy Avtalion, Ramy R |
| description | Abstract We report here an outbreak of an acute disease that caused high mortality rate in laboratory-reared tilapia larvae. The disease was initially observed in inbred gynogenetic line of blue tilapia larvae ( Oreochromis aureus ) and could be transmitted to larvae of other tilapia species. Based on the clinical manifestation (a whirling syndrome), we refer to the disease as viral encephalitis of tilapia larvae. The disease-associated DNA virus is described and accordingly designated tilapia larvae encephalitis virus (TLEV). A primary morphological, biophysical and molecular characterization of TLEV is presented. By virtue of these properties, the newly discovered virus is a herpes-like virus. Phylogenetic analysis, albeit limited, confirms this assumption and places TLEV within the family of Herpesviridae and distantly from the families Alloherpesviridae and Iridoviridae . By using PCR with virus-specific primers, diseased larvae and adult TLEV carriers were also identified in tilapia delivered from external hatcheries. |
| doi_str_mv | 10.1016/j.virol.2010.01.001 |
| format | Article |
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The disease was initially observed in inbred gynogenetic line of blue tilapia larvae ( Oreochromis aureus ) and could be transmitted to larvae of other tilapia species. Based on the clinical manifestation (a whirling syndrome), we refer to the disease as viral encephalitis of tilapia larvae. The disease-associated DNA virus is described and accordingly designated tilapia larvae encephalitis virus (TLEV). A primary morphological, biophysical and molecular characterization of TLEV is presented. By virtue of these properties, the newly discovered virus is a herpes-like virus. Phylogenetic analysis, albeit limited, confirms this assumption and places TLEV within the family of Herpesviridae and distantly from the families Alloherpesviridae and Iridoviridae . By using PCR with virus-specific primers, diseased larvae and adult TLEV carriers were also identified in tilapia delivered from external hatcheries.</description><identifier>ISSN: 0042-6822</identifier><identifier>EISSN: 1096-0341</identifier><identifier>DOI: 10.1016/j.virol.2010.01.001</identifier><identifier>PMID: 20117816</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Animals ; Antibodies, Viral - blood ; DNA, Viral - genetics ; Encephalitis ; Encephalitis, Viral - virology ; Female ; Herpes ; Herpes-like virus ; Herpesviridae ; Herpesviridae - classification ; Herpesviridae - genetics ; Herpesviridae - isolation & purification ; Herpesviridae Infections - virology ; Infectious Disease ; Iridoviridae ; Larva - virology ; Larvae ; Male ; Mice ; Mice, Inbred BALB C ; Microscopy, Electron, Transmission ; Molecular Sequence Data ; Oreochromis aureus ; Phylogeny ; Sequence Alignment ; Tilapia ; Tilapia - immunology ; Tilapia - virology</subject><ispartof>Virology (New York, N.Y.), 2010-04, Vol.399 (2), p.239-247</ispartof><rights>Elsevier Inc.</rights><rights>2010 Elsevier Inc.</rights><rights>Copyright 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-de331e9c701d1094475076edb00a99869d6c572fcacefe904f80ece4d2e4e40b3</citedby><cites>FETCH-LOGICAL-c445t-de331e9c701d1094475076edb00a99869d6c572fcacefe904f80ece4d2e4e40b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.virol.2010.01.001$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20117816$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shlapobersky, Mark</creatorcontrib><creatorcontrib>Sinyakov, Michael S</creatorcontrib><creatorcontrib>Katzenellenbogen, Mark</creatorcontrib><creatorcontrib>Sarid, Ronit</creatorcontrib><creatorcontrib>Don, Jeremy</creatorcontrib><creatorcontrib>Avtalion, Ramy R</creatorcontrib><title>Viral encephalitis of tilapia larvae: Primary characterization of a novel herpes-like virus</title><title>Virology (New York, N.Y.)</title><addtitle>Virology</addtitle><description>Abstract We report here an outbreak of an acute disease that caused high mortality rate in laboratory-reared tilapia larvae. 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The disease was initially observed in inbred gynogenetic line of blue tilapia larvae ( Oreochromis aureus ) and could be transmitted to larvae of other tilapia species. Based on the clinical manifestation (a whirling syndrome), we refer to the disease as viral encephalitis of tilapia larvae. The disease-associated DNA virus is described and accordingly designated tilapia larvae encephalitis virus (TLEV). A primary morphological, biophysical and molecular characterization of TLEV is presented. By virtue of these properties, the newly discovered virus is a herpes-like virus. Phylogenetic analysis, albeit limited, confirms this assumption and places TLEV within the family of Herpesviridae and distantly from the families Alloherpesviridae and Iridoviridae . 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Amino Acid Sequence Animals Antibodies, Viral - blood DNA, Viral - genetics Encephalitis Encephalitis, Viral - virology Female Herpes Herpes-like virus Herpesviridae Herpesviridae - classification Herpesviridae - genetics Herpesviridae - isolation & purification Herpesviridae Infections - virology Infectious Disease Iridoviridae Larva - virology Larvae Male Mice Mice, Inbred BALB C Microscopy, Electron, Transmission Molecular Sequence Data Oreochromis aureus Phylogeny Sequence Alignment Tilapia Tilapia - immunology Tilapia - virology |
| title | Viral encephalitis of tilapia larvae: Primary characterization of a novel herpes-like virus |
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