Matrix metalloproteinase–activated doxorubicin prodrugs inhibit HT1080 xenograft growth better than doxorubicin with less toxicity

Matrix metalloproteinase (MMP)–activated prodrugs were formed by coupling MMP-cleavable peptides to doxorubicin. The resulting conjugates were excellent in vitro substrates for MMP-2, -9, and -14. HT1080, a fibrosarcoma cell line, was used as a model system to test these prodrugs because these cells...

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Veröffentlicht in:	Molecular cancer therapeutics 2005-05, Vol.4 (5), p.751-760
Hauptverfasser:	Albright, Charles F, Graciani, Nilsa, Han, Wei, Yue, Eddy, Stein, Ross, Lai, Zhihong, Diamond, Melody, Dowling, Randine, Grimminger, Lisa, Zhang, Shu-Yun, Behrens, Davette, Musselman, Amy, Bruckner, Robert, Zhang, Mingzhu, Jiang, Xiang, Hu, Daniel, Higley, Anne, Dimeo, Susan, Rafalski, Maria, Mandlekar, Sandya, Car, Bruce, Yeleswaram, Swamy, Stern, Andrew, Copeland, Robert A, Combs, Andrew, Seitz, Steve P, Trainor, George L, Taub, Rebecca, Huang, Pearl, Oliff, Allen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Doxorubicin Doxorubicin - analogs & derivatives Doxorubicin - chemical synthesis Doxorubicin - pharmacology Drug Screening Assays, Antitumor Drug-Related Side Effects and Adverse Reactions Fibrosarcoma - drug therapy Fibrosarcoma - metabolism Humans Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism matrix metalloproteinases Matrix Metalloproteinases, Membrane-Associated Metalloendopeptidases - metabolism Mice Neprilysin - pharmacology Peptide Fragments - chemical synthesis Peptide Fragments - chemistry Peptide Fragments - pharmacology prodrugs Prodrugs - chemical synthesis Prodrugs - chemistry Prodrugs - pharmacology Reticulocytes - drug effects Reticulocytes - metabolism Transplantation, Heterologous Tumor Cells, Cultured
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