Preparation and Evaluation of Microencapsulated Ion-Exchange Resin Beads
Ion-exchange resin beads in the benzoate form were coated by several microencapsulation techniques to alter and improve characteristics, especially the control of drug release, of this type of drug delivery system. The most successful techniques included polymer-polymer interaction, temperature chan...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1979-02, Vol.68 (2), p.211-215 |
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| Format: | Artikel |
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| container_end_page | 215 |
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| container_issue | 2 |
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| container_title | Journal of pharmaceutical sciences |
| container_volume | 68 |
| creator | Motycka, S. Nairn, J.G. |
| description | Ion-exchange resin beads in the benzoate form were coated by several microencapsulation techniques to alter and improve characteristics, especially the control of drug release, of this type of drug delivery system. The most successful techniques included polymer-polymer interaction, temperature change, and nonsolvent addition. The microencapsulated beads then were studied with respect to the release rate of the organic anion to determine the effects of microencapsulation. The release rate of the organic anion could be controlled over a wide range, depending on the encapsulating material characteristics. Factors affecting the extent and rate of release as a result of microencapsulation are discussed. |
| doi_str_mv | 10.1002/jps.2600680223 |
| format | Article |
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The most successful techniques included polymer-polymer interaction, temperature change, and nonsolvent addition. The microencapsulated beads then were studied with respect to the release rate of the organic anion to determine the effects of microencapsulation. The release rate of the organic anion could be controlled over a wide range, depending on the encapsulating material characteristics. Factors affecting the extent and rate of release as a result of microencapsulation are discussed.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600680223</identifier><identifier>PMID: 423093</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Benzoates ; Capsules ; Chemistry, Pharmaceutical ; Delayed-Action Preparations ; Delivery systems-microencapsulated ion-exchange resin beads ; Delivery systems—microencapsulated ion-exchange resin beads, prepared by various methods, evaluated for release rate ; Dosage forms ; Dosage forms, potential—microencapsulated ion-exchange resin beads, prepared by various methods, evaluated for release rate ; evaluated for release rate ; Ion Exchange Resins ; Ion-exchange microencapsulated resin beads-prepared by various methods ; Ion-exchange microencapsulated resin beads—prepared by various methods, evaluated for release rate ; Kinetics ; Methods ; Microencapsulated ion-exchange resin beads-prepared by various methods ; Microencapsulated ion-exchange resin beads—prepared by various methods, evaluated for release rate ; Microspheres ; Polymers ; potential-microencapsulated ion-exchange resin beads ; prepared by various methods ; Solubility</subject><ispartof>Journal of pharmaceutical sciences, 1979-02, Vol.68 (2), p.211-215</ispartof><rights>1979 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4263-335e1113458703cb08d46e603da8c9fbcc6bcd24e1a4b225f15184ad0f04548d3</citedby><cites>FETCH-LOGICAL-c4263-335e1113458703cb08d46e603da8c9fbcc6bcd24e1a4b225f15184ad0f04548d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600680223$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600680223$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27902,27903,45552,45553</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/423093$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Motycka, S.</creatorcontrib><creatorcontrib>Nairn, J.G.</creatorcontrib><title>Preparation and Evaluation of Microencapsulated Ion-Exchange Resin Beads</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Ion-exchange resin beads in the benzoate form were coated by several microencapsulation techniques to alter and improve characteristics, especially the control of drug release, of this type of drug delivery system. The most successful techniques included polymer-polymer interaction, temperature change, and nonsolvent addition. The microencapsulated beads then were studied with respect to the release rate of the organic anion to determine the effects of microencapsulation. The release rate of the organic anion could be controlled over a wide range, depending on the encapsulating material characteristics. Factors affecting the extent and rate of release as a result of microencapsulation are discussed.</description><subject>Benzoates</subject><subject>Capsules</subject><subject>Chemistry, Pharmaceutical</subject><subject>Delayed-Action Preparations</subject><subject>Delivery systems-microencapsulated ion-exchange resin beads</subject><subject>Delivery systems—microencapsulated ion-exchange resin beads, prepared by various methods, evaluated for release rate</subject><subject>Dosage forms</subject><subject>Dosage forms, potential—microencapsulated ion-exchange resin beads, prepared by various methods, evaluated for release rate</subject><subject>evaluated for release rate</subject><subject>Ion Exchange Resins</subject><subject>Ion-exchange microencapsulated resin beads-prepared by various methods</subject><subject>Ion-exchange microencapsulated resin beads—prepared by various methods, evaluated for release rate</subject><subject>Kinetics</subject><subject>Methods</subject><subject>Microencapsulated ion-exchange resin beads-prepared by various methods</subject><subject>Microencapsulated ion-exchange resin beads—prepared by various methods, evaluated for release rate</subject><subject>Microspheres</subject><subject>Polymers</subject><subject>potential-microencapsulated ion-exchange resin beads</subject><subject>prepared by various methods</subject><subject>Solubility</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxa0KWpbClROHnHrLMv5M9girbbdVl36BOFqOPSku2SS1k9L-9xilKuJQ9TQaze896b0h5AOFOQVgn276OGcKQJXAGN8hMyoZ5Apo8YrMEsByLsXiDXkb4w0kDKTcI7uCcVjwGVmfB-xNMIPv2sy0LlvdmWac1q7ONt6GDltr-jg2ZkCXHXdtvrq3P017jdklRt9mX9C4-I68rk0T8f3j3CffD1ffluv89OzoePn5NLeCKZ5zLpFSyoUsC-C2gtIJhQq4M6Vd1JW1qrKOCaRGVIzJmkpaCuOgBiFF6fg-OZh8-9DdjhgHvfXRYtOYFrsx6kKIAlLGBM4nMCWIMWCt--C3JjxoCvpvczo1p_81lwQfH53HaovuCZ-qSufFdP7tG3x4wUyfnF_9Z51PWh8HvH_SmvBLq4IXUv_4eqSX6uRiXW42epn4cuIxNXnnMehofXoDOh_QDtp1_rkUfwBO_Zrq</recordid><startdate>197902</startdate><enddate>197902</enddate><creator>Motycka, S.</creator><creator>Nairn, J.G.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197902</creationdate><title>Preparation and Evaluation of Microencapsulated Ion-Exchange Resin Beads</title><author>Motycka, S. ; Nairn, J.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4263-335e1113458703cb08d46e603da8c9fbcc6bcd24e1a4b225f15184ad0f04548d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Benzoates</topic><topic>Capsules</topic><topic>Chemistry, Pharmaceutical</topic><topic>Delayed-Action Preparations</topic><topic>Delivery systems-microencapsulated ion-exchange resin beads</topic><topic>Delivery systems—microencapsulated ion-exchange resin beads, prepared by various methods, evaluated for release rate</topic><topic>Dosage forms</topic><topic>Dosage forms, potential—microencapsulated ion-exchange resin beads, prepared by various methods, evaluated for release rate</topic><topic>evaluated for release rate</topic><topic>Ion Exchange Resins</topic><topic>Ion-exchange microencapsulated resin beads-prepared by various methods</topic><topic>Ion-exchange microencapsulated resin beads—prepared by various methods, evaluated for release rate</topic><topic>Kinetics</topic><topic>Methods</topic><topic>Microencapsulated ion-exchange resin beads-prepared by various methods</topic><topic>Microencapsulated ion-exchange resin beads—prepared by various methods, evaluated for release rate</topic><topic>Microspheres</topic><topic>Polymers</topic><topic>potential-microencapsulated ion-exchange resin beads</topic><topic>prepared by various methods</topic><topic>Solubility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Motycka, S.</creatorcontrib><creatorcontrib>Nairn, J.G.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Motycka, S.</au><au>Nairn, J.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation and Evaluation of Microencapsulated Ion-Exchange Resin Beads</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1979-02</date><risdate>1979</risdate><volume>68</volume><issue>2</issue><spage>211</spage><epage>215</epage><pages>211-215</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>Ion-exchange resin beads in the benzoate form were coated by several microencapsulation techniques to alter and improve characteristics, especially the control of drug release, of this type of drug delivery system. The most successful techniques included polymer-polymer interaction, temperature change, and nonsolvent addition. The microencapsulated beads then were studied with respect to the release rate of the organic anion to determine the effects of microencapsulation. The release rate of the organic anion could be controlled over a wide range, depending on the encapsulating material characteristics. Factors affecting the extent and rate of release as a result of microencapsulation are discussed.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>423093</pmid><doi>10.1002/jps.2600680223</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1979-02, Vol.68 (2), p.211-215 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74470055 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Benzoates Capsules Chemistry, Pharmaceutical Delayed-Action Preparations Delivery systems-microencapsulated ion-exchange resin beads Delivery systems—microencapsulated ion-exchange resin beads, prepared by various methods, evaluated for release rate Dosage forms Dosage forms, potential—microencapsulated ion-exchange resin beads, prepared by various methods, evaluated for release rate evaluated for release rate Ion Exchange Resins Ion-exchange microencapsulated resin beads-prepared by various methods Ion-exchange microencapsulated resin beads—prepared by various methods, evaluated for release rate Kinetics Methods Microencapsulated ion-exchange resin beads-prepared by various methods Microencapsulated ion-exchange resin beads—prepared by various methods, evaluated for release rate Microspheres Polymers potential-microencapsulated ion-exchange resin beads prepared by various methods Solubility |
| title | Preparation and Evaluation of Microencapsulated Ion-Exchange Resin Beads |
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