Molecular Pathogenesis of Euthyroid and Toxic Multinodular Goiter

The purpose of this review is to summarize current knowledge of the etiology of euthyroid and toxic multinodular goiter (MNG) with respect to the epidemiology, clinical characteristics, and molecular pathology. In reconstructing the line of events from early thyroid hyperplasia to MNG we will argue...

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Veröffentlicht in:	Endocrine reviews 2005-06, Vol.26 (4), p.504-524
Hauptverfasser:	Krohn, Knut, Führer, Dagmar, Bayer, Yvonne, Eszlinger, Markus, Brauer, Volker, Neumann, Susanne, Paschke, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Transport Chromosome Aberrations Differential diagnosis Endocrinopathies Epidemiology Fundamental and applied biological sciences. Psychology Genetic Linkage Goiter Goiter, Nodular - genetics Goiter, Nodular - pathology Goiter, Nodular - physiopathology Humans Hyperplasia Intracellular Signaling Peptides and Proteins Iodides - metabolism Medical sciences Mutagenesis Mutation Non tumoral diseases. Target tissue resistance. Benign neoplasms Pathogenesis Protein Array Analysis Receptors, Thyrotropin - genetics Signal Transduction Thyroid Thyroid Gland - physiopathology Thyroid. Thyroid axis (diseases) Vertebrates: endocrinology
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