P2 receptor-mediated stimulation of the PI3-K/Akt-pathway in vivo

ATP acts as a growth factor as well as a toxic agent by stimulating P2 receptors. The P2 receptor‐activated signaling cascades mediating cellular growth and cell survival after injury are only incompletely understood. Therefore, the aim of the present study was to identify the role of the phosphoino...

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Veröffentlicht in:	Glia 2009-08, Vol.57 (10), p.1031-1045
Hauptverfasser:	Franke, H., Sauer, C., Rudolph, C., Krügel, U., Hengstler, J. G., Illes, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	active caspase 3 Adenosine Diphosphate - analogs & derivatives Adenosine Diphosphate - pharmacology Androstadienes - pharmacology Animals apoptosis Apoptosis - drug effects Apoptosis - physiology astrocytes Astrocytes - metabolism Astrocytes - pathology ATP Brain Injuries - metabolism Brain Injuries - pathology Brain Injuries - physiopathology Disease Models, Animal Enzyme Activation - drug effects Enzyme Activation - physiology Enzyme Inhibitors - pharmacology Flavonoids - pharmacology Gliosis - metabolism Gliosis - pathology Gliosis - physiopathology Male MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology MAPK/ERK-pathway Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Phosphatidylinositol 3-Kinases - metabolism Phosphorylation - drug effects Platelet Aggregation Inhibitors - pharmacology proliferation Proto-Oncogene Proteins c-akt - metabolism Pyridoxal Phosphate - analogs & derivatives Pyridoxal Phosphate - pharmacology Rats Rats, Wistar Receptors, Purinergic P2 - drug effects Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2Y1 Thionucleotides - pharmacology trauma Up-Regulation - drug effects Up-Regulation - physiology
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