Amphiregulin Causes Functional Downregulation of Adherens Junctions in Psoriasis

Overexpression of amphiregulin (AR) has been linked to psoriasis in mouse and man. Since psoriasis is marked by hyperproliferation of keratinocytes and loss of epidermal barrier function with infiltration of inflammatory cells into the epidermis and dermis, we hypothesized that AR might contribute t...

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Veröffentlicht in:	Journal of investigative dermatology 2005-06, Vol.124 (6), p.1134-1140
Hauptverfasser:	Chung, Eunkyung, Cook, Paul W., Parkos, Charles A., Park, Young-Kyu, Pittelkow, Mark R., Coffey, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adherens Junctions - drug effects Amphiregulin Animals Biological and medical sciences Cadherins - metabolism Cell Line Cells, Cultured Dermatology Dogs Down-Regulation E-cadherin EGF Family of Proteins Glycoproteins - metabolism Glycoproteins - pharmacology Humans Intercellular Signaling Peptides and Proteins - metabolism Intercellular Signaling Peptides and Proteins - pharmacology Male Medical sciences Mice Mice, Transgenic Neutrophil Infiltration - drug effects neutrophil transmigration Peptide Fragments - metabolism Proteins - metabolism psoriasis Psoriasis - metabolism Psoriasis - physiopathology Psoriasis. Parapsoriasis. Lichen Recombinant Proteins - pharmacology Tight Junctions - metabolism
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