A randomised phase III study on capecitabine, oxaliplatin and bevacizumab with or without cetuximab in first-line advanced colorectal cancer, the CAIRO2 study of the Dutch Colorectal Cancer Group (DCCG). An interim analysis of toxicity

Background: Targeting the vascular endothelial growth factor or the epidermal growth factor receptor (EGFR) has shown efficacy in advanced colorectal cancer (ACC), but no data are available on the combination of these strategies with chemotherapy in the first-line treatment. The CAIRO2 study evaluat...

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Veröffentlicht in:	Annals of oncology 2008-04, Vol.19 (4), p.734-738
Hauptverfasser:	Tol, J., Koopman, M., Rodenburg, C. J., Cats, A., Creemers, G. J., Schrama, J. G., Erdkamp, F. L. G., Vos, A. H., Mol, L., Antonini, N. F., Punt, C. J. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult advanced colorectal cancer Aged Aged, 80 and over Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal, Humanized Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bevacizumab Biological and medical sciences Capecitabine Carcinoma - drug therapy Carcinoma - mortality Carcinoma - secondary Cetuximab chemotherapy Colorectal Neoplasms - drug therapy Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Deoxycytidine - administration & dosage Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Disease-Free Survival Drug Eruptions - etiology Female Fluorouracil - administration & dosage Fluorouracil - adverse effects Fluorouracil - analogs & derivatives Gastroenterology. Liver. Pancreas. Abdomen Humans Incidence interim analysis Male Medical sciences Middle Aged Netherlands Organoplatinum Compounds - administration & dosage Organoplatinum Compounds - adverse effects Oxaliplatin Pharmacology. Drug treatments safety Severity of Illness Index Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Analysis Treatment Outcome Tumors
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