Elicitor-induced nitric oxide burst is essential for triggering catharanthine synthesis in Catharanthus roseus suspension cells
Elicitor prepared from the cell walls of Penicillium citrinum induced multiple responses in Catharanthus roseus suspension cells, including rapid generation of nitric oxide (NO), sequentially followed by enhancement of catharanthine production by C. roseus cells. Elicitor-induced catharanthine biosy...
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| Veröffentlicht in: | Applied microbiology and biotechnology 2005-04, Vol.67 (1), p.40-44 |
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| creator | Xu, Maojun Dong, Jufang |
| description | Elicitor prepared from the cell walls of Penicillium citrinum induced multiple responses in Catharanthus roseus suspension cells, including rapid generation of nitric oxide (NO), sequentially followed by enhancement of catharanthine production by C. roseus cells. Elicitor-induced catharanthine biosynthesis was blocked by NO-specific scavenger 2-4-carboxyphenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide and nitric oxide synthase (NOS) inhibitor S,S'-1,3-phenylene-bis(1,2-ethanediyl)-bis-isothiourea (PBITU). PBITU also strongly inhibited elicitor-induced NO generation by C. roseus suspension cells. The inhibiting effect of PBITU on elicitor-induced catharanthine production was reversed by external application of NO via the NO-donor sodium nitroprusside. The results strongly suggested that NO, generated by NOS or NOS-like enzymes in C. roseus suspension cells when treated with the fungal elicitor, was essential for triggering catharanthine synthesis. |
| doi_str_mv | 10.1007/s00253-004-1737-9 |
| format | Article |
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Elicitor-induced catharanthine biosynthesis was blocked by NO-specific scavenger 2-4-carboxyphenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide and nitric oxide synthase (NOS) inhibitor S,S'-1,3-phenylene-bis(1,2-ethanediyl)-bis-isothiourea (PBITU). PBITU also strongly inhibited elicitor-induced NO generation by C. roseus suspension cells. The inhibiting effect of PBITU on elicitor-induced catharanthine production was reversed by external application of NO via the NO-donor sodium nitroprusside. The results strongly suggested that NO, generated by NOS or NOS-like enzymes in C. roseus suspension cells when treated with the fungal elicitor, was essential for triggering catharanthine synthesis.</description><identifier>ISSN: 0175-7598</identifier><identifier>EISSN: 1432-0614</identifier><identifier>DOI: 10.1007/s00253-004-1737-9</identifier><identifier>PMID: 15480633</identifier><identifier>CODEN: AMBIDG</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Benzoates ; Biological and medical sciences ; Biosynthesis ; Biotechnology ; Catharanthus - drug effects ; Catharanthus - metabolism ; Catharanthus roseus ; Cell walls ; Enzyme Inhibitors - pharmacology ; Eukaryotic cell cultures ; Fundamental and applied biological sciences. Psychology ; Imidazoles ; Methods. Procedures. Technologies ; Miscellaneous ; Nitric oxide ; Nitric Oxide - metabolism ; Nitric Oxide Synthase - antagonists & inhibitors ; Nitric-oxide synthase ; Nitroprusside - metabolism ; Penicillium - chemistry ; Penicillium citrinum ; Plant cells and fungal cells ; Q1 ; Q2 ; Respiratory Burst ; sodium nitroprusside ; Suspension culture ; Thiourea - analogs & derivatives ; Thiourea - pharmacology ; Vinca Alkaloids - biosynthesis</subject><ispartof>Applied microbiology and biotechnology, 2005-04, Vol.67 (1), p.40-44</ispartof><rights>2005 INIST-CNRS</rights><rights>Springer-Verlag 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-7b7b2275455b6ac269bc96300ee51bf942bb5ef1149820021bac59a27d0b17713</citedby><cites>FETCH-LOGICAL-c388t-7b7b2275455b6ac269bc96300ee51bf942bb5ef1149820021bac59a27d0b17713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16687033$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15480633$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Maojun</creatorcontrib><creatorcontrib>Dong, Jufang</creatorcontrib><title>Elicitor-induced nitric oxide burst is essential for triggering catharanthine synthesis in Catharanthus roseus suspension cells</title><title>Applied microbiology and biotechnology</title><addtitle>Appl Microbiol Biotechnol</addtitle><description>Elicitor prepared from the cell walls of Penicillium citrinum induced multiple responses in Catharanthus roseus suspension cells, including rapid generation of nitric oxide (NO), sequentially followed by enhancement of catharanthine production by C. roseus cells. Elicitor-induced catharanthine biosynthesis was blocked by NO-specific scavenger 2-4-carboxyphenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide and nitric oxide synthase (NOS) inhibitor S,S'-1,3-phenylene-bis(1,2-ethanediyl)-bis-isothiourea (PBITU). PBITU also strongly inhibited elicitor-induced NO generation by C. roseus suspension cells. The inhibiting effect of PBITU on elicitor-induced catharanthine production was reversed by external application of NO via the NO-donor sodium nitroprusside. The results strongly suggested that NO, generated by NOS or NOS-like enzymes in C. roseus suspension cells when treated with the fungal elicitor, was essential for triggering catharanthine synthesis.</description><subject>Benzoates</subject><subject>Biological and medical sciences</subject><subject>Biosynthesis</subject><subject>Biotechnology</subject><subject>Catharanthus - drug effects</subject><subject>Catharanthus - metabolism</subject><subject>Catharanthus roseus</subject><subject>Cell walls</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Eukaryotic cell cultures</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Imidazoles</subject><subject>Methods. Procedures. Technologies</subject><subject>Miscellaneous</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>Nitric-oxide synthase</subject><subject>Nitroprusside - metabolism</subject><subject>Penicillium - chemistry</subject><subject>Penicillium citrinum</subject><subject>Plant cells and fungal cells</subject><subject>Q1</subject><subject>Q2</subject><subject>Respiratory Burst</subject><subject>sodium nitroprusside</subject><subject>Suspension culture</subject><subject>Thiourea - analogs & derivatives</subject><subject>Thiourea - pharmacology</subject><subject>Vinca Alkaloids - biosynthesis</subject><issn>0175-7598</issn><issn>1432-0614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc2KFDEURoMoTjv6AG4kCOoqepPKT2UpzTgKA250HZJUqidDdarNrYKZla9umm4ccOHqBnK-S_IdQl5z-MgBzCcEEKpjAJJx0xlmn5ANl51goLl8SjbAjWJG2f6CvEC8A-Ci1_o5ueBK9qC7bkN-X0055mWuLJdhjWmgJS81Rzrf5yHRsFZcaEaaEFNZsp_oOFfaiN0u1Vx2NPrl1ldflttcEsWHdkjYArnQ7d-rFWmdMbWBKx5SwTwXGtM04UvybPQTplfneUl-frn6sf3Kbr5ff9t-vmGx6_uFmWCCEEZJpYL2UWgbotUdQEqKh9FKEYJKI-fS9qK1woOPynphBgjcGN5dkg-nvYc6_1oTLm6f8fgCX9K8ojNSagNcH8n3_yW1Udr2yjTw7T_g3bzW0n7htOBKSQuiQfwExVYA1jS6Q817Xx8cB3eU6E4SXZPojhKdbZk358Vr2KfhMXG21oB3Z8Bj9NPYOo4ZHzmtewON-wNju6Yb</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>Xu, Maojun</creator><creator>Dong, Jufang</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>LK8</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20050401</creationdate><title>Elicitor-induced nitric oxide burst is essential for triggering catharanthine synthesis in Catharanthus roseus suspension cells</title><author>Xu, Maojun ; Dong, Jufang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-7b7b2275455b6ac269bc96300ee51bf942bb5ef1149820021bac59a27d0b17713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Benzoates</topic><topic>Biological and medical sciences</topic><topic>Biosynthesis</topic><topic>Biotechnology</topic><topic>Catharanthus - drug effects</topic><topic>Catharanthus - metabolism</topic><topic>Catharanthus roseus</topic><topic>Cell walls</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Eukaryotic cell cultures</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Imidazoles</topic><topic>Methods. Procedures. Technologies</topic><topic>Miscellaneous</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>Nitric-oxide synthase</topic><topic>Nitroprusside - metabolism</topic><topic>Penicillium - chemistry</topic><topic>Penicillium citrinum</topic><topic>Plant cells and fungal cells</topic><topic>Q1</topic><topic>Q2</topic><topic>Respiratory Burst</topic><topic>sodium nitroprusside</topic><topic>Suspension culture</topic><topic>Thiourea - analogs & derivatives</topic><topic>Thiourea - pharmacology</topic><topic>Vinca Alkaloids - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Maojun</creatorcontrib><creatorcontrib>Dong, Jufang</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ProQuest Biological Science Collection</collection><collection>ABI/INFORM Global</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Applied microbiology and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Maojun</au><au>Dong, Jufang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elicitor-induced nitric oxide burst is essential for triggering catharanthine synthesis in Catharanthus roseus suspension cells</atitle><jtitle>Applied microbiology and biotechnology</jtitle><addtitle>Appl Microbiol Biotechnol</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>67</volume><issue>1</issue><spage>40</spage><epage>44</epage><pages>40-44</pages><issn>0175-7598</issn><eissn>1432-0614</eissn><coden>AMBIDG</coden><abstract>Elicitor prepared from the cell walls of Penicillium citrinum induced multiple responses in Catharanthus roseus suspension cells, including rapid generation of nitric oxide (NO), sequentially followed by enhancement of catharanthine production by C. roseus cells. Elicitor-induced catharanthine biosynthesis was blocked by NO-specific scavenger 2-4-carboxyphenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide and nitric oxide synthase (NOS) inhibitor S,S'-1,3-phenylene-bis(1,2-ethanediyl)-bis-isothiourea (PBITU). PBITU also strongly inhibited elicitor-induced NO generation by C. roseus suspension cells. The inhibiting effect of PBITU on elicitor-induced catharanthine production was reversed by external application of NO via the NO-donor sodium nitroprusside. The results strongly suggested that NO, generated by NOS or NOS-like enzymes in C. roseus suspension cells when treated with the fungal elicitor, was essential for triggering catharanthine synthesis.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>15480633</pmid><doi>10.1007/s00253-004-1737-9</doi><tpages>5</tpages></addata></record> |
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| subjects | Benzoates Biological and medical sciences Biosynthesis Biotechnology Catharanthus - drug effects Catharanthus - metabolism Catharanthus roseus Cell walls Enzyme Inhibitors - pharmacology Eukaryotic cell cultures Fundamental and applied biological sciences. Psychology Imidazoles Methods. Procedures. Technologies Miscellaneous Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitric-oxide synthase Nitroprusside - metabolism Penicillium - chemistry Penicillium citrinum Plant cells and fungal cells Q1 Q2 Respiratory Burst sodium nitroprusside Suspension culture Thiourea - analogs & derivatives Thiourea - pharmacology Vinca Alkaloids - biosynthesis |
| title | Elicitor-induced nitric oxide burst is essential for triggering catharanthine synthesis in Catharanthus roseus suspension cells |
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