Haplotype-based case-control study of the human AGTR1 gene and essential hypertension in Han Chinese subjects
Essential hypertension is considered to be a multifactorial trait resulting from the combined influence of environmental and genetic determinants. The aim of the study is to assess the association between the human AGTR1 gene and essential hypertension (EH) using a haplotype-based case-control study...
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| Veröffentlicht in: | Clinical biochemistry 2010-02, Vol.43 (3), p.253-258 |
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| container_title | Clinical biochemistry |
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| creator | Nie, Sheng-jie Wen-ru, Tang Bi-feng, Chen Jin, Li Wen, Zhang Sheng-jun, Luo Wei-wei, Li Hai-jing, Yu Chun-jie, Xiao |
| description | Essential hypertension is considered to be a multifactorial trait resulting from the combined influence of environmental and genetic determinants. The aim of the study is to assess the association between the human AGTR1 gene and essential hypertension (EH) using a haplotype-based case-control study in Han Chinese subjects.
Seven tag SNPs and the A1166C polymorphism of the AGTR1 gene were genotyped in 510 hypertension subjects and 510 normotensive subjects using PCR-RFLP method.
Single SNP analyses indicated that the rs12695895 was significantly associated with hypertension, adjusted for covariates. Compared with the other haplotypes, Hap4 (AGGACTT) which carry the susceptible rs12695895 A allele was found to significantly increase the risk of EH with odds ratios equal to 1.84 (
p
=
0.0002).
The present results indicate that rs12695895 might be a genetic marker for EH and Hap4 (AGGACTT) was associated with hypertension in Han Chinese population. |
| doi_str_mv | 10.1016/j.clinbiochem.2009.09.027 |
| format | Article |
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Seven tag SNPs and the A1166C polymorphism of the AGTR1 gene were genotyped in 510 hypertension subjects and 510 normotensive subjects using PCR-RFLP method.
Single SNP analyses indicated that the rs12695895 was significantly associated with hypertension, adjusted for covariates. Compared with the other haplotypes, Hap4 (AGGACTT) which carry the susceptible rs12695895 A allele was found to significantly increase the risk of EH with odds ratios equal to 1.84 (
p
=
0.0002).
The present results indicate that rs12695895 might be a genetic marker for EH and Hap4 (AGGACTT) was associated with hypertension in Han Chinese population.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/j.clinbiochem.2009.09.027</identifier><identifier>PMID: 19833117</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Aged ; AGTR1 ; Alleles ; Arterial hypertension. Arterial hypotension ; Asian Continental Ancestry Group - genetics ; Association study ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - genetics ; Blood Pressure - physiology ; Cardiology. Vascular system ; Case-Control Studies ; Essential hypertension ; Female ; Genetic Markers ; Genetic Predisposition to Disease ; Genotype ; Haplotypes ; Humans ; Hypertension - genetics ; Male ; Medical sciences ; Middle Aged ; Polymorphism, Genetic ; Receptor, Angiotensin, Type 1 - genetics ; Single-nucleotide polymorphism ; tag SNP</subject><ispartof>Clinical biochemistry, 2010-02, Vol.43 (3), p.253-258</ispartof><rights>2009 The Canadian Society of Clinical Chemists</rights><rights>2015 INIST-CNRS</rights><rights>(c) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-c05cedc9282fe6938c1357896b4962241f1923a2cc0b67290ce80da6b6fae2813</citedby><cites>FETCH-LOGICAL-c438t-c05cedc9282fe6938c1357896b4962241f1923a2cc0b67290ce80da6b6fae2813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clinbiochem.2009.09.027$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22363336$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19833117$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nie, Sheng-jie</creatorcontrib><creatorcontrib>Wen-ru, Tang</creatorcontrib><creatorcontrib>Bi-feng, Chen</creatorcontrib><creatorcontrib>Jin, Li</creatorcontrib><creatorcontrib>Wen, Zhang</creatorcontrib><creatorcontrib>Sheng-jun, Luo</creatorcontrib><creatorcontrib>Wei-wei, Li</creatorcontrib><creatorcontrib>Hai-jing, Yu</creatorcontrib><creatorcontrib>Chun-jie, Xiao</creatorcontrib><title>Haplotype-based case-control study of the human AGTR1 gene and essential hypertension in Han Chinese subjects</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>Essential hypertension is considered to be a multifactorial trait resulting from the combined influence of environmental and genetic determinants. The aim of the study is to assess the association between the human AGTR1 gene and essential hypertension (EH) using a haplotype-based case-control study in Han Chinese subjects.
Seven tag SNPs and the A1166C polymorphism of the AGTR1 gene were genotyped in 510 hypertension subjects and 510 normotensive subjects using PCR-RFLP method.
Single SNP analyses indicated that the rs12695895 was significantly associated with hypertension, adjusted for covariates. Compared with the other haplotypes, Hap4 (AGGACTT) which carry the susceptible rs12695895 A allele was found to significantly increase the risk of EH with odds ratios equal to 1.84 (
p
=
0.0002).
The present results indicate that rs12695895 might be a genetic marker for EH and Hap4 (AGGACTT) was associated with hypertension in Han Chinese population.</description><subject>Adult</subject><subject>Aged</subject><subject>AGTR1</subject><subject>Alleles</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Association study</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - genetics</subject><subject>Blood Pressure - physiology</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Essential hypertension</subject><subject>Female</subject><subject>Genetic Markers</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Hypertension - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Receptor, Angiotensin, Type 1 - genetics</subject><subject>Single-nucleotide polymorphism</subject><subject>tag SNP</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV2LEzEUhoMobrf6FyReiFdT8zHNJJdLWbcLC4Ks1yGTOeOkzCQ1Z0bovzelRb1TOMkh5DkfvC8h7znbcMbVp8PGjyG2IfkBpo1gzGzOIZoXZMV1IythpHxJVqz8VIYLdkNuEQ_lKWqtXpMbbrSUnDcrMu3dcUzz6QhV6xA66std-RTnnEaK89KdaOrpPAAdlslFevfw_JXT7xCButhRQIQ4BzfSofTIM0QMKdIQ6b7AuyFEQKC4tAfwM74hr3o3Iry95jX59vn-ebevnr48PO7unipfSz1Xnm09dN4ILXpQRmrP5bbRRrW1UULUvOdGSCe8Z61qhGEeNOucalXvQGgu1-Tjpe8xpx8L4GyngB7G0UVIC9qmrpXS21r8m5RSy5pzU0hzIX1OiBl6e8xhcvlkObNnW-zB_mWLPdtizyGaUvvuOmVpJ-j-VF59KMCHK-DQu7HPLvqAvzkhpJKynDXZXTgo6v0MkC36ALGoFXIR2HYp_Mc6vwBtYrEv</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Nie, Sheng-jie</creator><creator>Wen-ru, Tang</creator><creator>Bi-feng, Chen</creator><creator>Jin, Li</creator><creator>Wen, Zhang</creator><creator>Sheng-jun, Luo</creator><creator>Wei-wei, Li</creator><creator>Hai-jing, Yu</creator><creator>Chun-jie, Xiao</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20100201</creationdate><title>Haplotype-based case-control study of the human AGTR1 gene and essential hypertension in Han Chinese subjects</title><author>Nie, Sheng-jie ; Wen-ru, Tang ; Bi-feng, Chen ; Jin, Li ; Wen, Zhang ; Sheng-jun, Luo ; Wei-wei, Li ; Hai-jing, Yu ; Chun-jie, Xiao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-c05cedc9282fe6938c1357896b4962241f1923a2cc0b67290ce80da6b6fae2813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>AGTR1</topic><topic>Alleles</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Association study</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - genetics</topic><topic>Blood Pressure - physiology</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Essential hypertension</topic><topic>Female</topic><topic>Genetic Markers</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Hypertension - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><topic>Receptor, Angiotensin, Type 1 - genetics</topic><topic>Single-nucleotide polymorphism</topic><topic>tag SNP</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nie, Sheng-jie</creatorcontrib><creatorcontrib>Wen-ru, Tang</creatorcontrib><creatorcontrib>Bi-feng, Chen</creatorcontrib><creatorcontrib>Jin, Li</creatorcontrib><creatorcontrib>Wen, Zhang</creatorcontrib><creatorcontrib>Sheng-jun, Luo</creatorcontrib><creatorcontrib>Wei-wei, Li</creatorcontrib><creatorcontrib>Hai-jing, Yu</creatorcontrib><creatorcontrib>Chun-jie, Xiao</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nie, Sheng-jie</au><au>Wen-ru, Tang</au><au>Bi-feng, Chen</au><au>Jin, Li</au><au>Wen, Zhang</au><au>Sheng-jun, Luo</au><au>Wei-wei, Li</au><au>Hai-jing, Yu</au><au>Chun-jie, Xiao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Haplotype-based case-control study of the human AGTR1 gene and essential hypertension in Han Chinese subjects</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>43</volume><issue>3</issue><spage>253</spage><epage>258</epage><pages>253-258</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>Essential hypertension is considered to be a multifactorial trait resulting from the combined influence of environmental and genetic determinants. The aim of the study is to assess the association between the human AGTR1 gene and essential hypertension (EH) using a haplotype-based case-control study in Han Chinese subjects.
Seven tag SNPs and the A1166C polymorphism of the AGTR1 gene were genotyped in 510 hypertension subjects and 510 normotensive subjects using PCR-RFLP method.
Single SNP analyses indicated that the rs12695895 was significantly associated with hypertension, adjusted for covariates. Compared with the other haplotypes, Hap4 (AGGACTT) which carry the susceptible rs12695895 A allele was found to significantly increase the risk of EH with odds ratios equal to 1.84 (
p
=
0.0002).
The present results indicate that rs12695895 might be a genetic marker for EH and Hap4 (AGGACTT) was associated with hypertension in Han Chinese population.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>19833117</pmid><doi>10.1016/j.clinbiochem.2009.09.027</doi><tpages>6</tpages></addata></record> |
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| ispartof | Clinical biochemistry, 2010-02, Vol.43 (3), p.253-258 |
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| subjects | Adult Aged AGTR1 Alleles Arterial hypertension. Arterial hypotension Asian Continental Ancestry Group - genetics Association study Biological and medical sciences Blood and lymphatic vessels Blood Pressure - genetics Blood Pressure - physiology Cardiology. Vascular system Case-Control Studies Essential hypertension Female Genetic Markers Genetic Predisposition to Disease Genotype Haplotypes Humans Hypertension - genetics Male Medical sciences Middle Aged Polymorphism, Genetic Receptor, Angiotensin, Type 1 - genetics Single-nucleotide polymorphism tag SNP |
| title | Haplotype-based case-control study of the human AGTR1 gene and essential hypertension in Han Chinese subjects |
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