Granzymes and perforin in solid organ transplant rejection
Rejection of solid organ allografts by the recipient immune system is mediated, to a major extent, by T cell effector mechanisms. Granzymes and perforin are protein regulators of cytotoxic T lymphocyte-mediated target cell death. In this review, I discuss clinical data implicating granzymes and perf...
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| Veröffentlicht in: | Cell death and differentiation 2010-04, Vol.17 (4), p.567-576 |
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| creator | Choy, J C |
| description | Rejection of solid organ allografts by the recipient immune system is mediated, to a major extent, by T cell effector mechanisms. Granzymes and perforin are protein regulators of cytotoxic T lymphocyte-mediated target cell death. In this review, I discuss clinical data implicating granzymes and perforin in acute and chronic solid organ transplant rejection, as well as data from cell and animal experiments that support a main role for these effector molecules in allograft rejection. |
| doi_str_mv | 10.1038/cdd.2009.161 |
| format | Article |
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Granzymes and perforin are protein regulators of cytotoxic T lymphocyte-mediated target cell death. 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immunology</topic><topic>Granzymes - physiology</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immune Tolerance - physiology</topic><topic>Immunity, Cellular - physiology</topic><topic>Immunosuppressive agents</topic><topic>Inflammation - immunology</topic><topic>Inflammation - physiopathology</topic><topic>Life Sciences</topic><topic>Lymphocytes</topic><topic>Mice</topic><topic>Mitochondria</topic><topic>Molecular biology</topic><topic>Perforin - physiology</topic><topic>Permeability</topic><topic>Proteins</topic><topic>review</topic><topic>Stem Cells</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>Transplantation, Homologous - immunology</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choy, J C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell death and differentiation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choy, J C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Granzymes and perforin in solid organ transplant rejection</atitle><jtitle>Cell death and differentiation</jtitle><stitle>Cell Death Differ</stitle><addtitle>Cell Death Differ</addtitle><date>2010-04-01</date><risdate>2010</risdate><volume>17</volume><issue>4</issue><spage>567</spage><epage>576</epage><pages>567-576</pages><issn>1350-9047</issn><eissn>1476-5403</eissn><abstract>Rejection of solid organ allografts by the recipient immune system is mediated, to a major extent, by T cell effector mechanisms. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals |
| subjects | Animals Apoptosis Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Cell death Cytochrome Cytotoxicity Genomes Graft Rejection - immunology Granzymes - physiology Humans Immune system Immune Tolerance - physiology Immunity, Cellular - physiology Immunosuppressive agents Inflammation - immunology Inflammation - physiopathology Life Sciences Lymphocytes Mice Mitochondria Molecular biology Perforin - physiology Permeability Proteins review Stem Cells T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Regulatory - immunology Transplantation, Homologous - immunology Transplants & implants |
| title | Granzymes and perforin in solid organ transplant rejection |
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