Implications of CD34+ cell dose on clinical and haematological outcome of allo-SCT for acquired aplastic anaemia
The precise effects of CD34+ cell dose on the outcome of allogeneic transplantation for aplastic anaemia (AA) are not known. Previous studies have used the total mononuclear cell count to quantify stem cell dose. We evaluated the effects of CD34+ cell dose on the clinical and haematological end poin...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2010-05, Vol.45 (5), p.886-894 |
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| creator | Islam, M S Anoop, P Datta-Nemdharry, P Sage, D Gordon-Smith, E C Turner, D Wiltshire, S O'Regan, L Marsh, J C W |
| description | The precise effects of CD34+ cell dose on the outcome of allogeneic transplantation for aplastic anaemia (AA) are not known. Previous studies have used the total mononuclear cell count to quantify stem cell dose. We evaluated the effects of CD34+ cell dose on the clinical and haematological end points of transplantation. The transplant variables and outcome parameters on 46 patients with acquired AA were assessed by comparing low vs high CD34+ cell doses. Infusion of less than 2 × 10
6
/kg of CD34+ cells was associated with an increased incidence of graft failures (
P
=0.03), higher incidence of bacterial infections (
P
=0.006) and a delay in the engraftment of neutrophils (
P
=0.046). The latter was found to be an effect of stem cell source (non-PBSC) rather than the CD34+ count. Other parameters, such as plt engraftment (
P
=0.63), red cell (
P
=0.94) and plt (
P
=0.31) transfusion independence, chimerism, acute and chronic GVHD (
P
=1.0) and OS (
P
=0.57), were not significantly influenced by the CD34+ cell dose. These findings are different to the published studies on the relevance of CD34+ cell dose in allogeneic transplantation for haematological cancers. |
| doi_str_mv | 10.1038/bmt.2009.267 |
| format | Article |
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6
/kg of CD34+ cells was associated with an increased incidence of graft failures (
P
=0.03), higher incidence of bacterial infections (
P
=0.006) and a delay in the engraftment of neutrophils (
P
=0.046). The latter was found to be an effect of stem cell source (non-PBSC) rather than the CD34+ count. Other parameters, such as plt engraftment (
P
=0.63), red cell (
P
=0.94) and plt (
P
=0.31) transfusion independence, chimerism, acute and chronic GVHD (
P
=1.0) and OS (
P
=0.57), were not significantly influenced by the CD34+ cell dose. These findings are different to the published studies on the relevance of CD34+ cell dose in allogeneic transplantation for haematological cancers.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/bmt.2009.267</identifier><identifier>PMID: 19820727</identifier><identifier>CODEN: BMTRE9</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adolescent ; Adult ; Anemia ; Anemia, Aplastic - immunology ; Anemia, Aplastic - therapy ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antigens, CD34 - immunology ; Aplastic anemia ; Bacterial diseases ; Biological and medical sciences ; Blood diseases ; Bone marrow ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Care and treatment ; CD34 antigen ; Cell Biology ; Child ; Child, Preschool ; Chimerism ; Diagnosis ; Female ; Genetic aspects ; Graft-versus-host reaction ; Hematologic and hematopoietic diseases ; Hematology ; Humans ; Internal Medicine ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Leukocytes (neutrophilic) ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; original-article ; Parameters ; Patient outcomes ; Public Health ; Retrospective Studies ; Risk factors ; Stem Cell Transplantation ; Stem Cells ; Transfusion ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Transplantation ; Transplantation, Homologous ; Transplants & implants ; Treatment Outcome ; Young Adult</subject><ispartof>Bone marrow transplantation (Basingstoke), 2010-05, Vol.45 (5), p.886-894</ispartof><rights>Macmillan Publishers Limited 2010</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 2010</rights><rights>Macmillan Publishers Limited 2010.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-819690901b35c906f811458de0ba1aab2ba3ada446cbc3d01097e9470057e6a33</citedby><cites>FETCH-LOGICAL-c504t-819690901b35c906f811458de0ba1aab2ba3ada446cbc3d01097e9470057e6a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/bmt.2009.267$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/bmt.2009.267$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22782828$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19820727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Islam, M S</creatorcontrib><creatorcontrib>Anoop, P</creatorcontrib><creatorcontrib>Datta-Nemdharry, P</creatorcontrib><creatorcontrib>Sage, D</creatorcontrib><creatorcontrib>Gordon-Smith, E C</creatorcontrib><creatorcontrib>Turner, D</creatorcontrib><creatorcontrib>Wiltshire, S</creatorcontrib><creatorcontrib>O'Regan, L</creatorcontrib><creatorcontrib>Marsh, J C W</creatorcontrib><title>Implications of CD34+ cell dose on clinical and haematological outcome of allo-SCT for acquired aplastic anaemia</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><addtitle>Bone Marrow Transplant</addtitle><description>The precise effects of CD34+ cell dose on the outcome of allogeneic transplantation for aplastic anaemia (AA) are not known. Previous studies have used the total mononuclear cell count to quantify stem cell dose. We evaluated the effects of CD34+ cell dose on the clinical and haematological end points of transplantation. The transplant variables and outcome parameters on 46 patients with acquired AA were assessed by comparing low vs high CD34+ cell doses. Infusion of less than 2 × 10
6
/kg of CD34+ cells was associated with an increased incidence of graft failures (
P
=0.03), higher incidence of bacterial infections (
P
=0.006) and a delay in the engraftment of neutrophils (
P
=0.046). The latter was found to be an effect of stem cell source (non-PBSC) rather than the CD34+ count. Other parameters, such as plt engraftment (
P
=0.63), red cell (
P
=0.94) and plt (
P
=0.31) transfusion independence, chimerism, acute and chronic GVHD (
P
=1.0) and OS (
P
=0.57), were not significantly influenced by the CD34+ cell dose. These findings are different to the published studies on the relevance of CD34+ cell dose in allogeneic transplantation for haematological cancers.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anemia</subject><subject>Anemia, Aplastic - immunology</subject><subject>Anemia, Aplastic - therapy</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antigens, CD34 - immunology</subject><subject>Aplastic anemia</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Blood diseases</subject><subject>Bone marrow</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Care and treatment</subject><subject>CD34 antigen</subject><subject>Cell Biology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chimerism</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Graft-versus-host reaction</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Leukocytes (neutrophilic)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>original-article</subject><subject>Parameters</subject><subject>Patient outcomes</subject><subject>Public Health</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Stem Cell Transplantation</subject><subject>Stem Cells</subject><subject>Transfusion</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Transplantation</subject><subject>Transplantation, Homologous</subject><subject>Transplants & implants</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0268-3369</issn><issn>1476-5365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqN0s2L1DAUAPAiijuu3jxLUNSDdnz5bo7L-LWw4MH1XF7TdKZL2swm7cH_3nRncFQUJIdA8nt575FXFE8prCnw6l0zTGsGYNZM6XvFigqtSsmVvF-sgKmq5FyZs-JRSjcAVAiQD4szaioGmulVsb8c9r63OPVhTCR0ZPOeizfEOu9JG5IjYSTW92MmnuDYkh26Aafgw_buKMyTDYNbItH7UH7dXJMuRIL2du6jawnuPaaptzk4R_b4uHjQoU_uyXE_L759_HC9-Vxeffl0ubm4Kq0EMZUVNcqAAdpwaQ2orqJUyKp10CBFbFiDHFsUQtnG8hYoGO2M0ABSO4WcnxevD-_uY7idXZrqoU9LWzi6MKda51CmGP0PybkEI5XJ8sUf8ibMccxt1EwJxpgwFWT1_J-KKqUlo_L01Ba9q_uxC1NEuySuLxjTuXvFdFavflE7h37apeDnu9_6Hb49QBtDStF19T72A8bvNYV6GZM6j0m9jEmudOHPjiXOzeDaEz7ORQYvjwBT_uYu4mj79NPlxBXLK7vy4FK-Grcunnr9a-IfIWnPTA</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Islam, M S</creator><creator>Anoop, P</creator><creator>Datta-Nemdharry, P</creator><creator>Sage, D</creator><creator>Gordon-Smith, E C</creator><creator>Turner, D</creator><creator>Wiltshire, S</creator><creator>O'Regan, L</creator><creator>Marsh, J C W</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20100501</creationdate><title>Implications of CD34+ cell dose on clinical and haematological outcome of allo-SCT for acquired aplastic anaemia</title><author>Islam, M S ; Anoop, P ; Datta-Nemdharry, P ; Sage, D ; Gordon-Smith, E C ; Turner, D ; Wiltshire, S ; O'Regan, L ; Marsh, J C W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-819690901b35c906f811458de0ba1aab2ba3ada446cbc3d01097e9470057e6a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anemia</topic><topic>Anemia, Aplastic - immunology</topic><topic>Anemia, Aplastic - therapy</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Antigens, CD34 - immunology</topic><topic>Aplastic anemia</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Blood diseases</topic><topic>Bone marrow</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Care and treatment</topic><topic>CD34 antigen</topic><topic>Cell Biology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chimerism</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Genetic aspects</topic><topic>Graft-versus-host reaction</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Leukocytes (neutrophilic)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>original-article</topic><topic>Parameters</topic><topic>Patient outcomes</topic><topic>Public Health</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>Stem Cell Transplantation</topic><topic>Stem Cells</topic><topic>Transfusion</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Transplantation</topic><topic>Transplantation, Homologous</topic><topic>Transplants & implants</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Islam, M S</creatorcontrib><creatorcontrib>Anoop, P</creatorcontrib><creatorcontrib>Datta-Nemdharry, P</creatorcontrib><creatorcontrib>Sage, D</creatorcontrib><creatorcontrib>Gordon-Smith, E C</creatorcontrib><creatorcontrib>Turner, D</creatorcontrib><creatorcontrib>Wiltshire, S</creatorcontrib><creatorcontrib>O'Regan, L</creatorcontrib><creatorcontrib>Marsh, J C W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Bone marrow transplantation (Basingstoke)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Islam, M S</au><au>Anoop, P</au><au>Datta-Nemdharry, P</au><au>Sage, D</au><au>Gordon-Smith, E C</au><au>Turner, D</au><au>Wiltshire, S</au><au>O'Regan, L</au><au>Marsh, J C W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Implications of CD34+ cell dose on clinical and haematological outcome of allo-SCT for acquired aplastic anaemia</atitle><jtitle>Bone marrow transplantation (Basingstoke)</jtitle><stitle>Bone Marrow Transplant</stitle><addtitle>Bone Marrow Transplant</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>45</volume><issue>5</issue><spage>886</spage><epage>894</epage><pages>886-894</pages><issn>0268-3369</issn><eissn>1476-5365</eissn><coden>BMTRE9</coden><abstract>The precise effects of CD34+ cell dose on the outcome of allogeneic transplantation for aplastic anaemia (AA) are not known. Previous studies have used the total mononuclear cell count to quantify stem cell dose. We evaluated the effects of CD34+ cell dose on the clinical and haematological end points of transplantation. The transplant variables and outcome parameters on 46 patients with acquired AA were assessed by comparing low vs high CD34+ cell doses. Infusion of less than 2 × 10
6
/kg of CD34+ cells was associated with an increased incidence of graft failures (
P
=0.03), higher incidence of bacterial infections (
P
=0.006) and a delay in the engraftment of neutrophils (
P
=0.046). The latter was found to be an effect of stem cell source (non-PBSC) rather than the CD34+ count. Other parameters, such as plt engraftment (
P
=0.63), red cell (
P
=0.94) and plt (
P
=0.31) transfusion independence, chimerism, acute and chronic GVHD (
P
=1.0) and OS (
P
=0.57), were not significantly influenced by the CD34+ cell dose. These findings are different to the published studies on the relevance of CD34+ cell dose in allogeneic transplantation for haematological cancers.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19820727</pmid><doi>10.1038/bmt.2009.267</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0268-3369 |
| ispartof | Bone marrow transplantation (Basingstoke), 2010-05, Vol.45 (5), p.886-894 |
| issn | 0268-3369 1476-5365 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_744626213 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Anemia Anemia, Aplastic - immunology Anemia, Aplastic - therapy Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antigens, CD34 - immunology Aplastic anemia Bacterial diseases Biological and medical sciences Blood diseases Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction Care and treatment CD34 antigen Cell Biology Child Child, Preschool Chimerism Diagnosis Female Genetic aspects Graft-versus-host reaction Hematologic and hematopoietic diseases Hematology Humans Internal Medicine Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocytes (neutrophilic) Male Medical sciences Medicine Medicine & Public Health Middle Aged original-article Parameters Patient outcomes Public Health Retrospective Studies Risk factors Stem Cell Transplantation Stem Cells Transfusion Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation, Homologous Transplants & implants Treatment Outcome Young Adult |
| title | Implications of CD34+ cell dose on clinical and haematological outcome of allo-SCT for acquired aplastic anaemia |
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