Oxidative Stress and Oxidative Damage in Carcinogenesis

Carcinogenesis is a multistep process involving mutation and the subsequent selective clonal expansion of the mutated cell. Chemical and physical agents including those that induce reative oxygen species can induce and/or modulate this multistep process. Several modes of action by which carcinogens...

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Veröffentlicht in:	Toxicologic pathology 2010-01, Vol.38 (1), p.96-109
Hauptverfasser:	Klaunig, James E., Kamendulis, Lisa M., Hocevar, Barbara A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents DNA Damage DNA Repair Humans Hypoxia-Inducible Factor 1 - physiology Liver Neoplasms, Experimental - etiology Medical sciences Neoplasms - etiology Neoplasms - genetics Neoplasms - metabolism NF-E2-Related Factor 2 - physiology Oxidation-Reduction Oxidative Stress Polymorphism, Genetic Reactive Oxygen Species - metabolism Toxicology Transcription Factor AP-1 - physiology Tumors
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