Incisor Degeneration in Rats Induced by Vascular Endothelial Growth Factor/Fibroblast Growth Factor Receptor Tyrosine Kinase Inhibition

BMS-645737, an inhibitor of vascular endothelial growth factor (VEGF) receptor-2 and fibroblast growth factor (FGF) receptor-1, has anti-angiogenic activity and was evaluated in nonclinical studies as a treatment for cancer. This article characterizes the BMS-645737-induced clinical, gross, and hist...

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Veröffentlicht in:	Toxicologic pathology 2010-02, Vol.38 (2), p.267-279
Hauptverfasser:	Fletcher, Anthony M., Bregman, Carla L., Woicke, Jochen, Salcedo, Theodora W., Zidell, Robert H., Janke, Helen E., Fang, Hengsheng, Janusz, William J., Schulze, Gene E., Mense, Mark G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - toxicity Animals Biological and medical sciences Dentin - metabolism Dose-Response Relationship, Drug Female Incisor - drug effects Incisor - pathology Male Medical sciences Necrosis Odontoblasts - drug effects Odontoblasts - metabolism Protein Kinase Inhibitors - toxicity Pyrroles - toxicity Rats Rats, Sprague-Dawley Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors Toxicity Tests Toxicology Triazines - toxicity Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors
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