Transcriptional regulation of endochondral ossification by HIF-2a during skeletal growth and osteoarthritis development

Chondrocyte hypertrophy followed by cartilage matrix degradation and vascular invasion, characterized by expression of type X collagen (COL10A1), matrix metalloproteinase-13 (MMP-13) and vascular endothelial growth factor (VEGF), respectively, are central steps of endochondral ossification during no...

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Veröffentlicht in:	Nature medicine 2010-06, Vol.16 (6), p.678-686
Hauptverfasser:	Saito, Taku, Fukai, Atsushi, Mabuchi, Akihiko, Ikeda, Toshiyuki, Yano, Fumiko, Ohba, Shinsuke, Nishida, Nao, Akune, Toru, Yoshimura, Noriko, Nakagawa, Takumi, Nakamura, Kozo, Tokunaga, Katsushi, Chung, Ung-il, Kawaguchi, Hiroshi
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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