Switch to a Sirolimus‐Based Immunosuppression in Long‐Term Renal Transplant Recipients: Reduced Rate of (Pre‐)Malignancies and Nonmelanoma Skin Cancer in a Prospective, Randomized, Assessor‐Blinded, Controlled Clinical Trial

Renal transplant recipients (RTR) have a 50–200‐fold higher risk for nonmelanoma‐skin cancer (NMSC) causing high rates of morbidity and sometimes mortality. Cohort‐studies gave evidence that a sirolimus‐based immunosuppression may inhibit skin tumor growth. This single‐center, prospective, assessor‐...

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Veröffentlicht in:	American journal of transplantation 2010-06, Vol.10 (6), p.1385-1393
Hauptverfasser:	Salgo, R., Gossmann, J., Schöfer, H., Kachel, H. G., Kuck, J., Geiger, H., Kaufmann, R., Scheuermann, E. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Carcinoma, Basal Cell - epidemiology Carcinoma, Basal Cell - etiology Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - etiology Dermatology Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immune Tolerance Immunosuppression Therapy - adverse effects Immunosuppressive Agents - administration & dosage Kidney Transplantation Longitudinal Studies Male Medical sciences Middle Aged mTOR inhibitor nonmelanoma skin cancer Precancerous Conditions - epidemiology Precancerous Conditions - etiology Prospective Studies renal transplant renal transplant recipient sirolimus Sirolimus - administration & dosage Sirolimus - adverse effects Skin Neoplasms - epidemiology Skin Neoplasms - etiology skin tumors Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology Tumors of the skin and soft tissue. Premalignant lesions
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