Pharmacokinetics of two generic co-formulations of lopinavir/ritonavir for HIV-infected children: a pilot study of paediatric Lopimune versus the branded product in healthy adult volunteers

Objectives To determine the pharmacokinetic profiles of lopinavir and ritonavir in two newly developed generic co-formulations for HIV-infected children (Lopimune paediatric tablets and granules, 100/25 mg of lopinavir/ritonavir, Cipla Pharmaceuticals), and to compare these with the branded product...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2010-03, Vol.65 (3), p.538-542
Hauptverfasser:	de Kanter, C. T. M. M., Colbers, E. P. H., Fillekes, Q., Hoitsma, A., Burger, D. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Anti-HIV Agents - administration & dosage Anti-HIV Agents - pharmacokinetics Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral drugs Biological and medical sciences Body weight Children Cross-Over Studies Drug therapy Female Food Generic drugs generics Granules HIV Human Experimentation Human immunodeficiency virus Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Lopinavir Male Medical sciences Middle Aged Pediatrics Pharmaceuticals Pharmacokinetics Pharmacology Pharmacology. Drug treatments Pilot Projects Plasma - chemistry Pyrimidinones - administration & dosage Pyrimidinones - pharmacokinetics Ritonavir Ritonavir - administration & dosage Ritonavir - pharmacokinetics Statistical analysis Stomach Tablets Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral infections Young Adult
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