Different selection patterns of resistance and cross-resistance to HIV-1 agents targeting CCR5

Objectives Identification of CCR5 as an antiretroviral target led to the development of several CCR5 antagonists in clinical trials and the approval of maraviroc. Evaluating the mechanism of drug resistance to CCR5 agents may have implications in the clinical development of this class of agents. We...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2010-03, Vol.65 (3), p.417-424
Hauptverfasser:	Armand-Ugón, Mercedes, Moncunill, Gemma, Gonzalez, Emmanuel, Mena, MariaPau, Ballana, Ester, Clotet, Bonaventura, Esté, José A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences CCR5 Receptor Antagonists Cell Line Cells, Cultured Clinical medicine Cyclohexanes - pharmacology Drug resistance Drug Resistance, Viral entry inhibitors Genotype & phenotype HIV HIV Envelope Protein gp120 - genetics HIV-1 - drug effects HIV-1 - genetics Human immunodeficiency virus Human immunodeficiency virus 1 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Inhibitory Concentration 50 Leukocytes, Mononuclear - virology maraviroc Medical research Medical sciences Microbial Sensitivity Tests Mutation Pharmacology. Drug treatments Quaternary Ammonium Compounds - pharmacology TAK-779 Triazoles - pharmacology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids virus entry
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