Two-component signal transduction as potential drug targets in pathogenic bacteria

Gene clusters contributing to processes such as cell growth and pathogenicity are often controlled by two-component signal transduction systems (TCSs). Specific inhibitors against TCS systems work differently from conventional antibiotics, and developing them into new drugs that are effective agains...

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Veröffentlicht in:	Current opinion in microbiology 2010-04, Vol.13 (2), p.232-239
Hauptverfasser:	Gotoh, Yasuhiro, Eguchi, Yoko, Watanabe, Takafumi, Okamoto, Sho, Doi, Akihiro, Utsumi, Ryutaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibiotics Bacteria - classification Bacteria - drug effects Bacteria - metabolism Bacteria - pathogenicity Bacterial Infections - microbiology Bacterial Proteins - drug effects Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Biological and medical sciences Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial - drug effects Histidine Kinase Humans Microbiology Miscellaneous Pathology Protein Kinase Inhibitors - pharmacology Protein Kinases - drug effects Protein Kinases - genetics Protein Kinases - metabolism Signal Transduction - drug effects Virulence - drug effects
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