ASAP1 promotes tumor cell motility and invasiveness, stimulates metastasis formation in vivo, and correlates with poor survival in colorectal cancer patients

We have previously performed an unbiased screen to identify genes whose expression is associated with the metastatic phenotype. Secondary screening of these genes using custom microarray chips identified ASAP1, a multi-domain adaptor protein with ADP-ribosylation factor-GAP activity, as being potent...

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Veröffentlicht in:	Oncogene 2010-04, Vol.29 (16), p.2393-2403
Hauptverfasser:	Müller, T, Stein, U, Poletti, A, Garzia, L, Rothley, M, Plaumann, D, Thiele, W, Bauer, M, Galasso, A, Schlag, P, Pankratz, M, Zollo, M, Sleeman, J P
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/322 631/80/84/2336 692/699/67/1504/1885 Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - physiology ADP-ribosylation factor Alternative Splicing Analysis Animal models Animals Apoptosis Biological and medical sciences Cancer Care and treatment Cell Adhesion Cell adhesion & migration Cell Biology Cell Line, Tumor Cell Movement Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cells Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Development and progression Disease Progression DNA microarrays Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene expression Gene Expression Profiling Genetic aspects Guanosine triphosphatase H protein Health aspects Human Genetics Humans Internal Medicine Invasiveness Medical prognosis Medical sciences Medicine Medicine & Public Health Metastases Metastasis Molecular and cellular biology Motility Neoplasm Invasiveness Neoplasm Metastasis Oncology original-article Patient outcomes Phenotypes Phosphodiesterase Physiological aspects Proteins Rats src Homology Domains Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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