Rational Design and Synthesis of 2,2-Bisheterocycle Tandem Derivatives as Non-Nucleoside Hepatitis B Virus Inhibitors

Non‐nucleoside tandem derivatives: Potent hepatitis B antiviral activity is established for 2,2′‐bisthiazole heterocyclic derivatives. The core structure of these compounds differs from those of known non‐nucleoside hepatitis B antiviral agents, constituting a new direction in hepatitis B virus drug...

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Veröffentlicht in:	ChemMedChem 2008-09, Vol.3 (9), p.1316-1321
Hauptverfasser:	Chen, Hai-Jun, Wang, Wen-Long, Wang, Gui-Feng, Shi, Li-Ping, Gu, Min, Ren, Yu-Dan, Hou, Li-Fei, He, Pei-Lan, Zhu, Feng-Hua, Zhong, Xian-Gen, Tang, Wei, Zuo, Jian-Ping, Nan, Fa-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	2,2′‐bisheterocycle tandem 2′-bisheterocycle tandem antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis Bridged Bicyclo Compounds, Heterocyclic - chemistry Bridged Bicyclo Compounds, Heterocyclic - pharmacology Drug Design Hepatitis B virus Hepatitis B virus - drug effects leucamide A Microbial Sensitivity Tests Molecular Structure non-nucleoside inhibitors Small Molecule Libraries Stereoisomerism Structure-Activity Relationship Thiazoles - chemical synthesis Thiazoles - chemistry Thiazoles - pharmacology Viral Nonstructural Proteins - drug effects Virus Replication - drug effects
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Beschreibung
Zusammenfassung:	Non‐nucleoside tandem derivatives: Potent hepatitis B antiviral activity is established for 2,2′‐bisthiazole heterocyclic derivatives. The core structure of these compounds differs from those of known non‐nucleoside hepatitis B antiviral agents, constituting a new direction in hepatitis B virus drug development.
ISSN:	1860-7179 1860-7187
DOI:	10.1002/cmdc.200800136