Testing for the BRCA1 and BRCA2 Breast-Ovarian Cancer Susceptibility Genes: A Decision Analysis

Objective. The authors developed a Markov decision model to evaluate the health implications of testing for mutations in the BRCA1 and BRCA2 breast-ovarian cancer susceptibility genes. Prophylactic measures considered included various combinations of immediate and delayed bilateral mastectomy and oo...

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Veröffentlicht in:	Medical decision making 1998-10, Vol.18 (4), p.365-375
Hauptverfasser:	Tengs, Tammy O., Winer, Eric P., Paddock, Susan, Aguilar-Chavez, Omar, Berry, Donald A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Breast Neoplasms - epidemiology Breast Neoplasms - genetics Breast Neoplasms - prevention & control Decision Support Techniques Female Genes, BRCA1 - physiology Genes, Tumor Suppressor - physiology Genetic Predisposition to Disease Genetic Testing Humans Incidence Markov Chains Mastectomy Middle Aged Ovarian cancer Ovarian Neoplasms - epidemiology Ovarian Neoplasms - genetics Ovarian Neoplasms - prevention & control Ovariectomy Predictive Value of Tests Quality-Adjusted Life Years Risk Assessment - methods Survival Analysis United States - epidemiology
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