Diphenyl Ether Non-Nucleoside Reverse Transcriptase Inhibitors with Excellent Potency Against Resistant Mutant Viruses and Promising Pharmacokinetic Properties (ChemMedChem 1/2009)
The cover picture shows a cut-away view of a diaryl ether non-nucleoside reverse transcriptase inhibitor (cyan) bound to HIV reverse transcriptase. The cartoon representation of the DNA template (teal) and primer (gold) strands, as well as the incoming nucleotide molecule, are shown as landmarks and...
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| Veröffentlicht in: | ChemMedChem 2009-01, Vol.4 (1), p.1-1 |
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| creator | Sweeney, Zachary K Kennedy-Smith, Joshua J Wu, Jeffrey Arora, Nidhi Billedeau, J Roland Davidson, James P Fretland, Jennifer Hang, Julie Q Heilek, Gabrielle M Harris, Seth F Hirschfeld, Donald Inbar, Petra Javanbakht, Hassan Jernelius, Jesper A Jin, Qingwu Li, Yu Liang, Weiling Roetz, Ralf Sarma, Keshab Smith, Mark Stefanidis, Dimitrio Su, Guoping Suh, Judy M Villasenor, Armando G Welch, Michael Zhang, Fang-Jie Klumpp, Klaus |
| description | The cover picture shows a cut-away view of a diaryl ether non-nucleoside reverse transcriptase inhibitor (cyan) bound to HIV reverse transcriptase. The cartoon representation of the DNA template (teal) and primer (gold) strands, as well as the incoming nucleotide molecule, are shown as landmarks and aligned from a separate structure (PDB code 1RTD). Binding of the non-nucleoside inhibitor interferes with the precise alignment and dynamics of the growing strand and the polymerase catalytic center. For more details, see the Full Paper by Z. K. Sweeney et al. on p. 88 ff. |
| doi_str_mv | 10.1002/cmdc.200990000 |
| format | Article |
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| identifier | ISSN: 1860-7179 |
| ispartof | ChemMedChem, 2009-01, Vol.4 (1), p.1-1 |
| issn | 1860-7179 |
| language | ger |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Human immunodeficiency virus |
| title | Diphenyl Ether Non-Nucleoside Reverse Transcriptase Inhibitors with Excellent Potency Against Resistant Mutant Viruses and Promising Pharmacokinetic Properties (ChemMedChem 1/2009) |
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