Synthesis of functional dipeptide carnosine from nonprotected amino acids using carnosinase-displaying yeast cells

Carnosine (β-alanyl-l-histidine) is one of the bioactive dipeptides and has antioxidant, antiglycation, and cytoplasmic buffering properties. In this study, to synthesize carnosine from nonprotected amino acids as substrates, we cloned the carnosinase (CN1) gene and constructed a whole-cell biocatal...

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Veröffentlicht in:	Applied microbiology and biotechnology 2010-05, Vol.86 (6), p.1895-1902
Hauptverfasser:	Inaba, Chiaki, Higuchi, Shinsuke, Morisaka, Hironobu, Kuroda, Kouichi, Ueda, Mitsuyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Antioxidants Applied Genetics and Molecular Biotechnology beta-Alanine - metabolism Biocatalysis Biocatalysts Bioengineering Biological and medical sciences Biomedical and Life Sciences Biotechnology Carnosine - biosynthesis Catalysts Cells Cloning, Molecular Dipeptidases - genetics Dipeptidases - metabolism Enzymes Freeze Drying Fundamental and applied biological sciences. Psychology Gene expression Genetic engineering Histidine - metabolism Humans Hydrolysis Hydrophobic and Hydrophilic Interactions Life Sciences Microbial Genetics and Genomics Microbiology Organic solvents Peptides Physiology Recombinant Proteins - metabolism Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Signal transduction Solvents Studies Substrate Specificity Transformation, Genetic Water content Yeast Yeasts
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