Antimycobacterial Metabolites from Plectranthus: Royleanone Derivatives against Mycobacterium tuberculosis Strains

The antimycobacterial activities of eight diterpenes, 1–8, isolated previously from Plectranthus and eleven esters, 9–19, of 7α‐acetoxy‐6β,12‐dihydroxyabieta‐8,12‐diene‐11,14‐dione (5) were evaluated against the MTB strains H37Rv and MDR. Only diterpenoids with a quinone framework revealed anti‐MTB...

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Veröffentlicht in:	Chemistry & biodiversity 2010-04, Vol.7 (4), p.922-932
Hauptverfasser:	Rijo, Patrícia, Simões, M. Fátima, Francisco, A. Paula, Rojas, Rosario, Gilman, Robert H., Vaisberg, Abraham J., Rodríguez, Benjamín, Moiteiro, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - toxicity Antimycobacterial activities Cercopithecus aethiops Diterpenes, Abietane - chemistry Diterpenes, Abietane - isolation & purification Diterpenes, Abietane - toxicity Drug Resistance, Multiple, Bacterial - drug effects Metabolites Mice Microbial Sensitivity Tests Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Plectranthus Plectranthus - chemistry Plectranthus - metabolism Plectranthus species Royleanone derivatives Vero Cells
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