N,N′-Methylenediimidazolium Salts: From Self-Assembly to an Efficient DNAse Protection System
We have developed N,N′‐dialkylmethylenediimidazolium salts ([CnCnDIM][X]2) that self‐organize into multilayered cationic vesicles and can interact with DNA. These preorganized systems form complexes with linear DNA and protect it from DNase I cleavage. All together now! N,N′‐Dialkylmethylenediimidaz...
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| Veröffentlicht in: | Chemistry : a European journal 2010-04, Vol.16 (15), p.4686-4692 |
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| container_title | Chemistry : a European journal |
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| creator | Pardin, Christophe Leclercq, Loïc Schmitzer, Andreea R. |
| description | We have developed N,N′‐dialkylmethylenediimidazolium salts ([CnCnDIM][X]2) that self‐organize into multilayered cationic vesicles and can interact with DNA. These preorganized systems form complexes with linear DNA and protect it from DNase I cleavage.
All together now! N,N′‐Dialkylmethylenediimidazolium salts were synthesized and showed self‐organization into multilayer vesicles. These vesicles exhibit hydrodynamic diameters that vary according to the alkyl chain length or the nature of the anion. In addition, linear double‐stranded (ds) DNA can be entrapped within the vesicles bilayer and can be protected towards enzymatic cleavage (see figure). |
| doi_str_mv | 10.1002/chem.200902794 |
| format | Article |
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All together now! N,N′‐Dialkylmethylenediimidazolium salts were synthesized and showed self‐organization into multilayer vesicles. These vesicles exhibit hydrodynamic diameters that vary according to the alkyl chain length or the nature of the anion. In addition, linear double‐stranded (ds) DNA can be entrapped within the vesicles bilayer and can be protected towards enzymatic cleavage (see figure).</description><identifier>ISSN: 0947-6539</identifier><identifier>EISSN: 1521-3765</identifier><identifier>DOI: 10.1002/chem.200902794</identifier><identifier>PMID: 20229530</identifier><identifier>CODEN: CEUJED</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Cationic ; Cations ; Chemistry ; Cleavage ; Deoxyribonuclease I - metabolism ; Deoxyribonucleic acid ; diimidazolium salts ; DNA - metabolism ; DNA interactions ; enzymes ; Fluid dynamics ; Hydrogen Bonding ; Imidazoles - chemical synthesis ; Imidazoles - chemistry ; Models, Chemical ; Molecular Structure ; Multilayers ; Plasmids - chemistry ; Protection systems ; Salts - chemical synthesis ; Salts - chemistry ; Self assembly ; Vesicles</subject><ispartof>Chemistry : a European journal, 2010-04, Vol.16 (15), p.4686-4692</ispartof><rights>Copyright © 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6494-74888581161a9189875bbeaaf883e03842b3d779b13c25b2b7739f9df6ad128c3</citedby><cites>FETCH-LOGICAL-c6494-74888581161a9189875bbeaaf883e03842b3d779b13c25b2b7739f9df6ad128c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fchem.200902794$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fchem.200902794$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20229530$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pardin, Christophe</creatorcontrib><creatorcontrib>Leclercq, Loïc</creatorcontrib><creatorcontrib>Schmitzer, Andreea R.</creatorcontrib><title>N,N′-Methylenediimidazolium Salts: From Self-Assembly to an Efficient DNAse Protection System</title><title>Chemistry : a European journal</title><addtitle>Chemistry - A European Journal</addtitle><description>We have developed N,N′‐dialkylmethylenediimidazolium salts ([CnCnDIM][X]2) that self‐organize into multilayered cationic vesicles and can interact with DNA. These preorganized systems form complexes with linear DNA and protect it from DNase I cleavage.
All together now! N,N′‐Dialkylmethylenediimidazolium salts were synthesized and showed self‐organization into multilayer vesicles. These vesicles exhibit hydrodynamic diameters that vary according to the alkyl chain length or the nature of the anion. In addition, linear double‐stranded (ds) DNA can be entrapped within the vesicles bilayer and can be protected towards enzymatic cleavage (see figure).</description><subject>Cationic</subject><subject>Cations</subject><subject>Chemistry</subject><subject>Cleavage</subject><subject>Deoxyribonuclease I - metabolism</subject><subject>Deoxyribonucleic acid</subject><subject>diimidazolium salts</subject><subject>DNA - metabolism</subject><subject>DNA interactions</subject><subject>enzymes</subject><subject>Fluid dynamics</subject><subject>Hydrogen Bonding</subject><subject>Imidazoles - chemical synthesis</subject><subject>Imidazoles - chemistry</subject><subject>Models, Chemical</subject><subject>Molecular Structure</subject><subject>Multilayers</subject><subject>Plasmids - chemistry</subject><subject>Protection systems</subject><subject>Salts - chemical synthesis</subject><subject>Salts - chemistry</subject><subject>Self assembly</subject><subject>Vesicles</subject><issn>0947-6539</issn><issn>1521-3765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctu1DAYRi1ERYeWLUsUiQUsyOD7pbthmGmR2lCpBSQ2lpP8UV1yKXEiCCueiUfqk-Bqygh1QfHGXpzvLHwQekrwnGBMXxcX0MwpxgZTZfgDNCOCkpQpKR6iGTZcpVIws4seh3CJIyYZe4R2KabUCIZnyGavsuufv9ITGC6mGloovW986X50tR-b5MzVQzhI1n0X31BX6SIEaPJ6SoYucW2yqipfeGiH5G22CJCc9t0AxeC7NjmbwgDNPtqpXB3gye29hz6sV-fLo_T4_eG75eI4LSQ3PFVcay00IZI4Q7TRSuQ5OFdpzQAzzWnOSqVMTlhBRU5zpZipTFlJVxKqC7aHXmy8V333dYQw2MaHAuratdCNwSrOJSFRG8mX_ySJxpgbZQy5H1VKxqPEf1g5ZxxjwlREn99BL7uxb-PvRKGUwkRKR2q-oYq-C6GHyl71vnH9ZAm2N-ntTXq7TR8Hz261Y95AucX_tI6A2QDffA3TPTq7PFqd_C1PN1sfo37fbl3_xUrFlLCfskOr9On5Ovv80b5hvwFyuceS</recordid><startdate>20100419</startdate><enddate>20100419</enddate><creator>Pardin, Christophe</creator><creator>Leclercq, Loïc</creator><creator>Schmitzer, Andreea R.</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>K9.</scope><scope>7X8</scope><scope>7TM</scope></search><sort><creationdate>20100419</creationdate><title>N,N′-Methylenediimidazolium Salts: From Self-Assembly to an Efficient DNAse Protection System</title><author>Pardin, Christophe ; Leclercq, Loïc ; Schmitzer, Andreea R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6494-74888581161a9189875bbeaaf883e03842b3d779b13c25b2b7739f9df6ad128c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Cationic</topic><topic>Cations</topic><topic>Chemistry</topic><topic>Cleavage</topic><topic>Deoxyribonuclease I - metabolism</topic><topic>Deoxyribonucleic acid</topic><topic>diimidazolium salts</topic><topic>DNA - metabolism</topic><topic>DNA interactions</topic><topic>enzymes</topic><topic>Fluid dynamics</topic><topic>Hydrogen Bonding</topic><topic>Imidazoles - chemical synthesis</topic><topic>Imidazoles - chemistry</topic><topic>Models, Chemical</topic><topic>Molecular Structure</topic><topic>Multilayers</topic><topic>Plasmids - chemistry</topic><topic>Protection systems</topic><topic>Salts - chemical synthesis</topic><topic>Salts - chemistry</topic><topic>Self assembly</topic><topic>Vesicles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pardin, Christophe</creatorcontrib><creatorcontrib>Leclercq, Loïc</creatorcontrib><creatorcontrib>Schmitzer, Andreea R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Chemistry : a European journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pardin, Christophe</au><au>Leclercq, Loïc</au><au>Schmitzer, Andreea R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N,N′-Methylenediimidazolium Salts: From Self-Assembly to an Efficient DNAse Protection System</atitle><jtitle>Chemistry : a European journal</jtitle><addtitle>Chemistry - A European Journal</addtitle><date>2010-04-19</date><risdate>2010</risdate><volume>16</volume><issue>15</issue><spage>4686</spage><epage>4692</epage><pages>4686-4692</pages><issn>0947-6539</issn><eissn>1521-3765</eissn><coden>CEUJED</coden><abstract>We have developed N,N′‐dialkylmethylenediimidazolium salts ([CnCnDIM][X]2) that self‐organize into multilayered cationic vesicles and can interact with DNA. These preorganized systems form complexes with linear DNA and protect it from DNase I cleavage.
All together now! N,N′‐Dialkylmethylenediimidazolium salts were synthesized and showed self‐organization into multilayer vesicles. These vesicles exhibit hydrodynamic diameters that vary according to the alkyl chain length or the nature of the anion. In addition, linear double‐stranded (ds) DNA can be entrapped within the vesicles bilayer and can be protected towards enzymatic cleavage (see figure).</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>20229530</pmid><doi>10.1002/chem.200902794</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Cationic Cations Chemistry Cleavage Deoxyribonuclease I - metabolism Deoxyribonucleic acid diimidazolium salts DNA - metabolism DNA interactions enzymes Fluid dynamics Hydrogen Bonding Imidazoles - chemical synthesis Imidazoles - chemistry Models, Chemical Molecular Structure Multilayers Plasmids - chemistry Protection systems Salts - chemical synthesis Salts - chemistry Self assembly Vesicles |
| title | N,N′-Methylenediimidazolium Salts: From Self-Assembly to an Efficient DNAse Protection System |
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