Biological and behavioral effects of one night's sleep deprivation in depressed patients and normals
Twenty-five patients with major depressive illness and 20 normal volunteers were sleep deprived for one night in order to assess mood, physiology, and biochemistry. Fifteen patients showed mild to moderate improvement in depression, normally lasting one day, while volunteers tended to experience sli...
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| Veröffentlicht in: | Journal of psychiatric research 1979, Vol.15 (1), p.21-40 |
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| container_title | Journal of psychiatric research |
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| creator | Gerner, Robert H. Post, Robert M. Gillin, Christian Bunney, William E. |
| description | Twenty-five patients with major depressive illness and 20 normal volunteers were sleep deprived for one night in order to assess mood, physiology, and biochemistry. Fifteen patients showed mild to moderate improvement in depression, normally lasting one day, while volunteers tended to experience slight increases in dysphoria following sleep deprivation (SD). Prior to SD depressed patient responders had lower baseline levels of HVA in CSF than non-responders. Following SD responders tended to have decreases in CSF calcium and MHPG and increases in serum cortisol compared to nonresponders. Nonresponders also showed a flattened diurnal temperature rhythm following SD. Alterations in central neurotransmitters, circadian rhythms, and stress activation are discussed as possible mediators of the selective mood improvement in depressed patients compared to normal volunteer controls. |
| doi_str_mv | 10.1016/0022-3956(79)90004-9 |
| format | Article |
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Fifteen patients showed mild to moderate improvement in depression, normally lasting one day, while volunteers tended to experience slight increases in dysphoria following sleep deprivation (SD). Prior to SD depressed patient responders had lower baseline levels of HVA in CSF than non-responders. Following SD responders tended to have decreases in CSF calcium and MHPG and increases in serum cortisol compared to nonresponders. Nonresponders also showed a flattened diurnal temperature rhythm following SD. Alterations in central neurotransmitters, circadian rhythms, and stress activation are discussed as possible mediators of the selective mood improvement in depressed patients compared to normal volunteer controls.</description><identifier>ISSN: 0022-3956</identifier><identifier>EISSN: 1879-1379</identifier><identifier>DOI: 10.1016/0022-3956(79)90004-9</identifier><identifier>PMID: 219193</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Aged ; Bipolar Disorder - metabolism ; Bipolar Disorder - psychology ; Body Temperature ; Calcium - cerebrospinal fluid ; Circadian Rhythm ; Depression - metabolism ; Depression - psychology ; Electroencephalography ; Emotions - physiology ; Glycols - cerebrospinal fluid ; Homovanillic Acid - cerebrospinal fluid ; Humans ; Hydrocortisone - blood ; Hydroxyindoleacetic Acid - cerebrospinal fluid ; Methoxyhydroxyphenylglycol - cerebrospinal fluid ; Middle Aged ; Phenylacetates - cerebrospinal fluid ; Sleep Deprivation ; Sleep, REM - physiology</subject><ispartof>Journal of psychiatric research, 1979, Vol.15 (1), p.21-40</ispartof><rights>1979</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-8a8ba9e36a0defb1600061b577d64c6236a8109e11a56a0105d47ac6b7ebb8143</citedby><cites>FETCH-LOGICAL-c422t-8a8ba9e36a0defb1600061b577d64c6236a8109e11a56a0105d47ac6b7ebb8143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0022-3956(79)90004-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/219193$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gerner, Robert H.</creatorcontrib><creatorcontrib>Post, Robert M.</creatorcontrib><creatorcontrib>Gillin, Christian</creatorcontrib><creatorcontrib>Bunney, William E.</creatorcontrib><title>Biological and behavioral effects of one night's sleep deprivation in depressed patients and normals</title><title>Journal of psychiatric research</title><addtitle>J Psychiatr Res</addtitle><description>Twenty-five patients with major depressive illness and 20 normal volunteers were sleep deprived for one night in order to assess mood, physiology, and biochemistry. Fifteen patients showed mild to moderate improvement in depression, normally lasting one day, while volunteers tended to experience slight increases in dysphoria following sleep deprivation (SD). Prior to SD depressed patient responders had lower baseline levels of HVA in CSF than non-responders. Following SD responders tended to have decreases in CSF calcium and MHPG and increases in serum cortisol compared to nonresponders. Nonresponders also showed a flattened diurnal temperature rhythm following SD. Alterations in central neurotransmitters, circadian rhythms, and stress activation are discussed as possible mediators of the selective mood improvement in depressed patients compared to normal volunteer controls.</description><subject>Adult</subject><subject>Aged</subject><subject>Bipolar Disorder - metabolism</subject><subject>Bipolar Disorder - psychology</subject><subject>Body Temperature</subject><subject>Calcium - cerebrospinal fluid</subject><subject>Circadian Rhythm</subject><subject>Depression - metabolism</subject><subject>Depression - psychology</subject><subject>Electroencephalography</subject><subject>Emotions - physiology</subject><subject>Glycols - cerebrospinal fluid</subject><subject>Homovanillic Acid - cerebrospinal fluid</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Hydroxyindoleacetic Acid - cerebrospinal fluid</subject><subject>Methoxyhydroxyphenylglycol - cerebrospinal fluid</subject><subject>Middle Aged</subject><subject>Phenylacetates - cerebrospinal fluid</subject><subject>Sleep Deprivation</subject><subject>Sleep, REM - physiology</subject><issn>0022-3956</issn><issn>1879-1379</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlOwzAQhi3EVgpv0INPLIeAnbh2fEGCik2qxAXOlmNPWqMkDnZaibfHXcSR02j8L_J8CE0ouaWE8jtC8jwr5JRfC3kjCSEskwdoREshM1oIeYhGf5ZTdBbjV_KInLITdJxTSWUxQvbR-cYvnNEN1p3FFSz12vmQVqhrMEPEvsa-A9y5xXK4ijg2AD220Ae31oPzHXbddoUYweI-vUGXYpu2zodWN_EcHdVpwMV-jtHn89PH7DWbv7-8zR7mmWF5PmSlListoeCaWKgrytN3Oa2mQljODM-TUFIigVI9TR5KppYJbXgloKpKyooxutz19sF_ryAOqnXRQNPoDvwqKsEYJ5zlych2RhN8jAFqla5pdfhRlKgNW7UBpzbglJBqy1bJFJvs-1dVC_YvtIOZ5PudDOnGtYOgokksDFgXEkllvfu__xeDNojp</recordid><startdate>1979</startdate><enddate>1979</enddate><creator>Gerner, Robert H.</creator><creator>Post, Robert M.</creator><creator>Gillin, Christian</creator><creator>Bunney, William E.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1979</creationdate><title>Biological and behavioral effects of one night's sleep deprivation in depressed patients and normals</title><author>Gerner, Robert H. ; Post, Robert M. ; Gillin, Christian ; Bunney, William E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-8a8ba9e36a0defb1600061b577d64c6236a8109e11a56a0105d47ac6b7ebb8143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Bipolar Disorder - metabolism</topic><topic>Bipolar Disorder - psychology</topic><topic>Body Temperature</topic><topic>Calcium - cerebrospinal fluid</topic><topic>Circadian Rhythm</topic><topic>Depression - metabolism</topic><topic>Depression - psychology</topic><topic>Electroencephalography</topic><topic>Emotions - physiology</topic><topic>Glycols - cerebrospinal fluid</topic><topic>Homovanillic Acid - cerebrospinal fluid</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Hydroxyindoleacetic Acid - cerebrospinal fluid</topic><topic>Methoxyhydroxyphenylglycol - cerebrospinal fluid</topic><topic>Middle Aged</topic><topic>Phenylacetates - cerebrospinal fluid</topic><topic>Sleep Deprivation</topic><topic>Sleep, REM - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gerner, Robert H.</creatorcontrib><creatorcontrib>Post, Robert M.</creatorcontrib><creatorcontrib>Gillin, Christian</creatorcontrib><creatorcontrib>Bunney, William E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychiatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gerner, Robert H.</au><au>Post, Robert M.</au><au>Gillin, Christian</au><au>Bunney, William E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biological and behavioral effects of one night's sleep deprivation in depressed patients and normals</atitle><jtitle>Journal of psychiatric research</jtitle><addtitle>J Psychiatr Res</addtitle><date>1979</date><risdate>1979</risdate><volume>15</volume><issue>1</issue><spage>21</spage><epage>40</epage><pages>21-40</pages><issn>0022-3956</issn><eissn>1879-1379</eissn><abstract>Twenty-five patients with major depressive illness and 20 normal volunteers were sleep deprived for one night in order to assess mood, physiology, and biochemistry. Fifteen patients showed mild to moderate improvement in depression, normally lasting one day, while volunteers tended to experience slight increases in dysphoria following sleep deprivation (SD). Prior to SD depressed patient responders had lower baseline levels of HVA in CSF than non-responders. Following SD responders tended to have decreases in CSF calcium and MHPG and increases in serum cortisol compared to nonresponders. Nonresponders also showed a flattened diurnal temperature rhythm following SD. Alterations in central neurotransmitters, circadian rhythms, and stress activation are discussed as possible mediators of the selective mood improvement in depressed patients compared to normal volunteer controls.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>219193</pmid><doi>10.1016/0022-3956(79)90004-9</doi><tpages>20</tpages></addata></record> |
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| identifier | ISSN: 0022-3956 |
| ispartof | Journal of psychiatric research, 1979, Vol.15 (1), p.21-40 |
| issn | 0022-3956 1879-1379 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Aged Bipolar Disorder - metabolism Bipolar Disorder - psychology Body Temperature Calcium - cerebrospinal fluid Circadian Rhythm Depression - metabolism Depression - psychology Electroencephalography Emotions - physiology Glycols - cerebrospinal fluid Homovanillic Acid - cerebrospinal fluid Humans Hydrocortisone - blood Hydroxyindoleacetic Acid - cerebrospinal fluid Methoxyhydroxyphenylglycol - cerebrospinal fluid Middle Aged Phenylacetates - cerebrospinal fluid Sleep Deprivation Sleep, REM - physiology |
| title | Biological and behavioral effects of one night's sleep deprivation in depressed patients and normals |
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