Specific Effects of a Hepatoma on Metabolic Capabilities of the Liver in Tumor-Bearing Rats
Summary The presence of a transplantable hepatoma led to changes in host liver metabolic capabilities during the early stages of tumor growth. The changes included increases of liver wet weight and cathepsin activity and decreases of fructose-1,6-diphosphatase activity, microsomal drug-metabolizing...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1979-01, Vol.160 (1), p.11-17 |
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| container_end_page | 17 |
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| container_issue | 1 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 160 |
| creator | Strittmatter, Cornelius F. |
| description | Summary
The presence of a transplantable hepatoma led to changes in host liver metabolic capabilities during the early stages of tumor growth. The changes included increases of liver wet weight and cathepsin activity and decreases of fructose-1,6-diphosphatase activity, microsomal drug-metabolizing activities, cytochrome P-450 and NADPH-cytochrome c reductase activity. The nature and early appearance of these changes and the failure of liver implants to produce similar changes suggest that there may be specific directive effects of the tumor on host tissues. The low respiratory control ratio seen with hepatoma mitochondria preparations did not reflect an increased rate of deterioration with storage. |
| doi_str_mv | 10.3181/00379727-160-40378 |
| format | Article |
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The presence of a transplantable hepatoma led to changes in host liver metabolic capabilities during the early stages of tumor growth. The changes included increases of liver wet weight and cathepsin activity and decreases of fructose-1,6-diphosphatase activity, microsomal drug-metabolizing activities, cytochrome P-450 and NADPH-cytochrome c reductase activity. The nature and early appearance of these changes and the failure of liver implants to produce similar changes suggest that there may be specific directive effects of the tumor on host tissues. The low respiratory control ratio seen with hepatoma mitochondria preparations did not reflect an increased rate of deterioration with storage.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-160-40378</identifier><identifier>PMID: 368811</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Female ; Liver - metabolism ; Liver - pathology ; Liver Neoplasms, Experimental - metabolism ; Liver Neoplasms, Experimental - pathology ; Liver Transplantation ; Microsomes, Liver - metabolism ; Oxygen Consumption ; Rats ; Rats, Inbred ACI ; Time Factors ; Transplantation, Isogeneic</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1979-01, Vol.160 (1), p.11-17</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-3ce5a178716518828e5d037c20f268e82b4ec46ce52b5c6bafc58b389206f65f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/368811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Strittmatter, Cornelius F.</creatorcontrib><title>Specific Effects of a Hepatoma on Metabolic Capabilities of the Liver in Tumor-Bearing Rats</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
The presence of a transplantable hepatoma led to changes in host liver metabolic capabilities during the early stages of tumor growth. The changes included increases of liver wet weight and cathepsin activity and decreases of fructose-1,6-diphosphatase activity, microsomal drug-metabolizing activities, cytochrome P-450 and NADPH-cytochrome c reductase activity. The nature and early appearance of these changes and the failure of liver implants to produce similar changes suggest that there may be specific directive effects of the tumor on host tissues. The low respiratory control ratio seen with hepatoma mitochondria preparations did not reflect an increased rate of deterioration with storage.</description><subject>Animals</subject><subject>Female</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver Neoplasms, Experimental - metabolism</subject><subject>Liver Neoplasms, Experimental - pathology</subject><subject>Liver Transplantation</subject><subject>Microsomes, Liver - metabolism</subject><subject>Oxygen Consumption</subject><subject>Rats</subject><subject>Rats, Inbred ACI</subject><subject>Time Factors</subject><subject>Transplantation, Isogeneic</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLlOxDAQhi3EtRwvgChc0QV8xI5TwopLWoTEUVFYjhmDURIHO0Hi7fGyQEk1Gs03v2Y-hA4oOeZU0RNCeFVXrCqoJEWZG7WGZlRwUXBZ1-totgSKJbGNdlJ6I4SKiskttMmlUpTO0NP9ANY7b_G5c2DHhIPDBl_BYMbQGRx6fAOjaUKbkbkZTONbP3r45sZXwAv_ARH7Hj9MXYjFGZjo-xd8Z8a0hzacaRPs_9Rd9Hhx_jC_Kha3l9fz00VhOa_GglsQhlaqolJQpZgC8ZzPtow4JhUo1pRgS5kp1ggrG-OsUA1XNSPSSeH4Ljpa5Q4xvE-QRt35ZKFtTQ9hSroqS1FTIjLIVqCNIaUITg_RdyZ-akr0Uqj-FaqzUP0tNC8d_qRPTQfPfysrg3l8shon8wL6LUyxz7_-F_gFgfh9DA</recordid><startdate>197901</startdate><enddate>197901</enddate><creator>Strittmatter, Cornelius F.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197901</creationdate><title>Specific Effects of a Hepatoma on Metabolic Capabilities of the Liver in Tumor-Bearing Rats</title><author>Strittmatter, Cornelius F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-3ce5a178716518828e5d037c20f268e82b4ec46ce52b5c6bafc58b389206f65f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animals</topic><topic>Female</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Liver Neoplasms, Experimental - metabolism</topic><topic>Liver Neoplasms, Experimental - pathology</topic><topic>Liver Transplantation</topic><topic>Microsomes, Liver - metabolism</topic><topic>Oxygen Consumption</topic><topic>Rats</topic><topic>Rats, Inbred ACI</topic><topic>Time Factors</topic><topic>Transplantation, Isogeneic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Strittmatter, Cornelius F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Strittmatter, Cornelius F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Specific Effects of a Hepatoma on Metabolic Capabilities of the Liver in Tumor-Bearing Rats</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1979-01</date><risdate>1979</risdate><volume>160</volume><issue>1</issue><spage>11</spage><epage>17</epage><pages>11-17</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
The presence of a transplantable hepatoma led to changes in host liver metabolic capabilities during the early stages of tumor growth. The changes included increases of liver wet weight and cathepsin activity and decreases of fructose-1,6-diphosphatase activity, microsomal drug-metabolizing activities, cytochrome P-450 and NADPH-cytochrome c reductase activity. The nature and early appearance of these changes and the failure of liver implants to produce similar changes suggest that there may be specific directive effects of the tumor on host tissues. The low respiratory control ratio seen with hepatoma mitochondria preparations did not reflect an increased rate of deterioration with storage.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>368811</pmid><doi>10.3181/00379727-160-40378</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1979-01, Vol.160 (1), p.11-17 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74459105 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Female Liver - metabolism Liver - pathology Liver Neoplasms, Experimental - metabolism Liver Neoplasms, Experimental - pathology Liver Transplantation Microsomes, Liver - metabolism Oxygen Consumption Rats Rats, Inbred ACI Time Factors Transplantation, Isogeneic |
| title | Specific Effects of a Hepatoma on Metabolic Capabilities of the Liver in Tumor-Bearing Rats |
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