Iontophoretic Terbinafine HCL 1.0% Delivery Across Porcine and Human Nails
Background Onychomycosis is a common disease. Topical treatment is usually not effective due to limitation of trans-nail delivery of antifungal drugs. Successful treatment of deep-seated nail infections remains elusive as the delivery of efficacious levels of antifungal drug to the site of action is...
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| Veröffentlicht in: | Mycopathologia (1975) 2010-05, Vol.169 (5), p.343-349 |
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| creator | Amichai, Boaz Mosckovitz, Rachel Trau, Henri Sholto, Orit Ben-Yaakov, Shirly Royz, Michael Barak, David Nitzan, Boaz Shemer, Avner |
| description | Background Onychomycosis is a common disease. Topical treatment is usually not effective due to limitation of trans-nail delivery of antifungal drugs. Successful treatment of deep-seated nail infections remains elusive as the delivery of efficacious levels of antifungal drug to the site of action is very difficult. Objectives To evaluate the influence of several parameters including; the effect of low electrical current, incubation time and the presence of electrolyte (NaCl or KCl) on the penetration of terbinafine through the nail plate into the nail bed, using various formulations and concentrations of terbinafine HCl. Methods Iontophoresis was applied across porcine and human nail in vitro to assess its efficiency in enhancing delivery of terbinafine HCl. Results In this study, we have demonstrated that an optimal electrolyte concentration (1% NaCl or KCl) is required for an effective delivery. There is a significant increase in drug delivery into the nail and into the receiving compartment in the presence of 3% DMSO. Conclusions This study demonstrates the efficacy of iontophoresis in enhancing the trans-nail delivery of terbinafine. Clinical studies are needed to evaluate the feasibility, efficacy and safety of iontophoresis of terbinafine in onychomycosis in human. |
| doi_str_mv | 10.1007/s11046-009-9265-x |
| format | Article |
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Topical treatment is usually not effective due to limitation of trans-nail delivery of antifungal drugs. Successful treatment of deep-seated nail infections remains elusive as the delivery of efficacious levels of antifungal drug to the site of action is very difficult. Objectives To evaluate the influence of several parameters including; the effect of low electrical current, incubation time and the presence of electrolyte (NaCl or KCl) on the penetration of terbinafine through the nail plate into the nail bed, using various formulations and concentrations of terbinafine HCl. Methods Iontophoresis was applied across porcine and human nail in vitro to assess its efficiency in enhancing delivery of terbinafine HCl. Results In this study, we have demonstrated that an optimal electrolyte concentration (1% NaCl or KCl) is required for an effective delivery. There is a significant increase in drug delivery into the nail and into the receiving compartment in the presence of 3% DMSO. Conclusions This study demonstrates the efficacy of iontophoresis in enhancing the trans-nail delivery of terbinafine. Clinical studies are needed to evaluate the feasibility, efficacy and safety of iontophoresis of terbinafine in onychomycosis in human.</description><identifier>ISSN: 0301-486X</identifier><identifier>EISSN: 1573-0832</identifier><identifier>DOI: 10.1007/s11046-009-9265-x</identifier><identifier>PMID: 20012894</identifier><language>eng</language><publisher>Dordrecht: Dordrecht : Springer Netherlands</publisher><subject>Animals ; Antifungal agents ; Antifungal Agents - administration & dosage ; Biomedical and Life Sciences ; Dimethyl Sulfoxide - administration & dosage ; Drug delivery systems ; Drugs ; Electric currents ; Electrolytes ; Eukaryotic Microbiology ; Experiments ; Health aspects ; Hepatitis ; Hoof and Claw ; Humans ; Iontophoresis ; Iontophoresis - methods ; Life Sciences ; Medical Microbiology ; Microbial Ecology ; Microbiology ; Mycoses ; Nails ; Naphthalenes - administration & dosage ; Onychomycosis - drug therapy ; Permeability ; Plant Sciences ; Swine ; Terbinafine ; Vehicles</subject><ispartof>Mycopathologia (1975), 2010-05, Vol.169 (5), p.343-349</ispartof><rights>Springer Science+Business Media B.V. 2009</rights><rights>COPYRIGHT 2010 Springer</rights><rights>Springer Science+Business Media B.V. 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-e6e23695dce97565b7210c56c76f6f89e39cc19dada52af987be4b1d134e95693</citedby><cites>FETCH-LOGICAL-c527t-e6e23695dce97565b7210c56c76f6f89e39cc19dada52af987be4b1d134e95693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11046-009-9265-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11046-009-9265-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20012894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amichai, Boaz</creatorcontrib><creatorcontrib>Mosckovitz, Rachel</creatorcontrib><creatorcontrib>Trau, Henri</creatorcontrib><creatorcontrib>Sholto, Orit</creatorcontrib><creatorcontrib>Ben-Yaakov, Shirly</creatorcontrib><creatorcontrib>Royz, Michael</creatorcontrib><creatorcontrib>Barak, David</creatorcontrib><creatorcontrib>Nitzan, Boaz</creatorcontrib><creatorcontrib>Shemer, Avner</creatorcontrib><title>Iontophoretic Terbinafine HCL 1.0% Delivery Across Porcine and Human Nails</title><title>Mycopathologia (1975)</title><addtitle>Mycopathologia</addtitle><addtitle>Mycopathologia</addtitle><description>Background Onychomycosis is a common disease. Topical treatment is usually not effective due to limitation of trans-nail delivery of antifungal drugs. Successful treatment of deep-seated nail infections remains elusive as the delivery of efficacious levels of antifungal drug to the site of action is very difficult. Objectives To evaluate the influence of several parameters including; the effect of low electrical current, incubation time and the presence of electrolyte (NaCl or KCl) on the penetration of terbinafine through the nail plate into the nail bed, using various formulations and concentrations of terbinafine HCl. Methods Iontophoresis was applied across porcine and human nail in vitro to assess its efficiency in enhancing delivery of terbinafine HCl. Results In this study, we have demonstrated that an optimal electrolyte concentration (1% NaCl or KCl) is required for an effective delivery. There is a significant increase in drug delivery into the nail and into the receiving compartment in the presence of 3% DMSO. Conclusions This study demonstrates the efficacy of iontophoresis in enhancing the trans-nail delivery of terbinafine. Clinical studies are needed to evaluate the feasibility, efficacy and safety of iontophoresis of terbinafine in onychomycosis in human.</description><subject>Animals</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - administration & dosage</subject><subject>Biomedical and Life Sciences</subject><subject>Dimethyl Sulfoxide - administration & dosage</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>Electric currents</subject><subject>Electrolytes</subject><subject>Eukaryotic Microbiology</subject><subject>Experiments</subject><subject>Health aspects</subject><subject>Hepatitis</subject><subject>Hoof and Claw</subject><subject>Humans</subject><subject>Iontophoresis</subject><subject>Iontophoresis - methods</subject><subject>Life Sciences</subject><subject>Medical Microbiology</subject><subject>Microbial Ecology</subject><subject>Microbiology</subject><subject>Mycoses</subject><subject>Nails</subject><subject>Naphthalenes - administration & dosage</subject><subject>Onychomycosis - drug therapy</subject><subject>Permeability</subject><subject>Plant Sciences</subject><subject>Swine</subject><subject>Terbinafine</subject><subject>Vehicles</subject><issn>0301-486X</issn><issn>1573-0832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkl2L1DAYhYso7rj6A7zRsiLiRcd8NF-Xw_gxI4OKuwvehUz6dszSNmPSyuy_N92uyogouXghec4hJzlZ9hijOUZIvIoYo5IXCKlCEc6Kw51shpmgBZKU3M1miCJclJJ_OckexHiFUFJhcT87IWkSqcpZ9n7tu97vv_oAvbP5BYSt60ztOshXy02O5-h5_hoa9x3Cdb6wwceYf_LBjoDpqnw1tKbLPxjXxIfZvdo0ER7dztPs8u2bi-Wq2Hx8t14uNoVlRPQFcCCUK1ZZUIJxthUEI8u4FbzmtVRAlbVYVaYyjJhaSbGFcosrTEtQjCt6mr2YfPfBfxsg9rp10ULTmA78ELUoS6bSw5T_JymVkqISJfLsD_LKD6FLMTQhGFMubqBnE7QzDWjX1b4Pxo6WekGZlKXCZLze_C9UWhW0zvoOapf2jwQvjwSJ6eHQ78wQo16ffz5m8cTe_ESAWu-Da0241hjpsRN66oROndBjJ_QhaZ7cZhu2LVS_FD9LkAAyATEddTsIv8P_y_XpJKqN12YXXNSX5wThVDlJFBaM_gD0ucXe</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Amichai, Boaz</creator><creator>Mosckovitz, Rachel</creator><creator>Trau, Henri</creator><creator>Sholto, Orit</creator><creator>Ben-Yaakov, Shirly</creator><creator>Royz, Michael</creator><creator>Barak, David</creator><creator>Nitzan, Boaz</creator><creator>Shemer, Avner</creator><general>Dordrecht : Springer Netherlands</general><general>Springer Netherlands</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20100501</creationdate><title>Iontophoretic Terbinafine HCL 1.0% Delivery Across Porcine and Human Nails</title><author>Amichai, Boaz ; Mosckovitz, Rachel ; Trau, Henri ; Sholto, Orit ; Ben-Yaakov, Shirly ; Royz, Michael ; Barak, David ; Nitzan, Boaz ; Shemer, Avner</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-e6e23695dce97565b7210c56c76f6f89e39cc19dada52af987be4b1d134e95693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - administration & dosage</topic><topic>Biomedical and Life Sciences</topic><topic>Dimethyl Sulfoxide - administration & dosage</topic><topic>Drug delivery systems</topic><topic>Drugs</topic><topic>Electric currents</topic><topic>Electrolytes</topic><topic>Eukaryotic Microbiology</topic><topic>Experiments</topic><topic>Health aspects</topic><topic>Hepatitis</topic><topic>Hoof and Claw</topic><topic>Humans</topic><topic>Iontophoresis</topic><topic>Iontophoresis - methods</topic><topic>Life Sciences</topic><topic>Medical Microbiology</topic><topic>Microbial Ecology</topic><topic>Microbiology</topic><topic>Mycoses</topic><topic>Nails</topic><topic>Naphthalenes - administration & dosage</topic><topic>Onychomycosis - drug therapy</topic><topic>Permeability</topic><topic>Plant Sciences</topic><topic>Swine</topic><topic>Terbinafine</topic><topic>Vehicles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amichai, Boaz</creatorcontrib><creatorcontrib>Mosckovitz, Rachel</creatorcontrib><creatorcontrib>Trau, Henri</creatorcontrib><creatorcontrib>Sholto, Orit</creatorcontrib><creatorcontrib>Ben-Yaakov, Shirly</creatorcontrib><creatorcontrib>Royz, Michael</creatorcontrib><creatorcontrib>Barak, David</creatorcontrib><creatorcontrib>Nitzan, Boaz</creatorcontrib><creatorcontrib>Shemer, Avner</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - 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Topical treatment is usually not effective due to limitation of trans-nail delivery of antifungal drugs. Successful treatment of deep-seated nail infections remains elusive as the delivery of efficacious levels of antifungal drug to the site of action is very difficult. Objectives To evaluate the influence of several parameters including; the effect of low electrical current, incubation time and the presence of electrolyte (NaCl or KCl) on the penetration of terbinafine through the nail plate into the nail bed, using various formulations and concentrations of terbinafine HCl. Methods Iontophoresis was applied across porcine and human nail in vitro to assess its efficiency in enhancing delivery of terbinafine HCl. Results In this study, we have demonstrated that an optimal electrolyte concentration (1% NaCl or KCl) is required for an effective delivery. There is a significant increase in drug delivery into the nail and into the receiving compartment in the presence of 3% DMSO. Conclusions This study demonstrates the efficacy of iontophoresis in enhancing the trans-nail delivery of terbinafine. Clinical studies are needed to evaluate the feasibility, efficacy and safety of iontophoresis of terbinafine in onychomycosis in human.</abstract><cop>Dordrecht</cop><pub>Dordrecht : Springer Netherlands</pub><pmid>20012894</pmid><doi>10.1007/s11046-009-9265-x</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Antifungal agents Antifungal Agents - administration & dosage Biomedical and Life Sciences Dimethyl Sulfoxide - administration & dosage Drug delivery systems Drugs Electric currents Electrolytes Eukaryotic Microbiology Experiments Health aspects Hepatitis Hoof and Claw Humans Iontophoresis Iontophoresis - methods Life Sciences Medical Microbiology Microbial Ecology Microbiology Mycoses Nails Naphthalenes - administration & dosage Onychomycosis - drug therapy Permeability Plant Sciences Swine Terbinafine Vehicles |
| title | Iontophoretic Terbinafine HCL 1.0% Delivery Across Porcine and Human Nails |
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