CK-MM Gene Polymorphism Does not Influence the Blood CK Activity Levels After Exhaustive Eccentric Exercise
Abstract Gene variants, such as creatine kinase (CK) polymorphisms, have been suggested to explain the inter-individual blood CK response to eccentric exercise. However, since this association is still doubtful, the purpose of this study was to analyse the relationship between the magnitudes of the...
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| Veröffentlicht in: | International journal of sports medicine 2010-03, Vol.31 (3), p.213-217 |
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| container_title | International journal of sports medicine |
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| creator | Yamin, C. Oliveira, J. Meckel, Y. Eynon, N. Sagiv, M. Ayalon, M. Alves, A. J. Duarte, J. A. |
| description | Abstract
Gene variants, such as creatine kinase (CK) polymorphisms, have been suggested to explain the inter-individual blood CK response to eccentric exercise. However, since this association is still doubtful, the purpose of this study was to analyse the relationship between the magnitudes of the CK response to exercise with the occurrence of muscle CK-MM NcoI polymorphism in young healthy subjects. Blood CK activity was assessed in 70 subjects immediately before and 3, 24, 48, 72, 96, 120, 168 h after strenuous eccentric exercise. Based on the amount of CK release by each subject, the sample was distributed in quartiles and the genotype and allele frequency distribution was compared among quartiles. Despite the inter-individual variability of CK response observed between subjects, there were no differences in genotype and allele frequencies among quartiles. The results allowed us to conclude that CK response after exhaustive eccentric exercise is not associated with CK-MM Ncol polymorphism. |
| doi_str_mv | 10.1055/s-0029-1243256 |
| format | Article |
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Gene variants, such as creatine kinase (CK) polymorphisms, have been suggested to explain the inter-individual blood CK response to eccentric exercise. However, since this association is still doubtful, the purpose of this study was to analyse the relationship between the magnitudes of the CK response to exercise with the occurrence of muscle CK-MM NcoI polymorphism in young healthy subjects. Blood CK activity was assessed in 70 subjects immediately before and 3, 24, 48, 72, 96, 120, 168 h after strenuous eccentric exercise. Based on the amount of CK release by each subject, the sample was distributed in quartiles and the genotype and allele frequency distribution was compared among quartiles. Despite the inter-individual variability of CK response observed between subjects, there were no differences in genotype and allele frequencies among quartiles. The results allowed us to conclude that CK response after exhaustive eccentric exercise is not associated with CK-MM Ncol polymorphism.</description><identifier>ISSN: 0172-4622</identifier><identifier>EISSN: 1439-3964</identifier><identifier>DOI: 10.1055/s-0029-1243256</identifier><identifier>PMID: 20157874</identifier><identifier>CODEN: IJSMDA</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Adult ; Biological and medical sciences ; Biomarkers ; Creatine Kinase - blood ; Creatine Kinase - genetics ; Creatine Kinase, MM Form - blood ; Creatine Kinase, MM Form - genetics ; Exercise - physiology ; Exercise Tolerance - genetics ; Exercise Tolerance - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Genetics & Molecular Biology ; Genotype ; Humans ; Male ; Motor Activity ; Muscle, Skeletal - physiology ; Polymorphism, Genetic ; Sex Factors ; Time Factors ; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><ispartof>International journal of sports medicine, 2010-03, Vol.31 (3), p.213-217</ispartof><rights>Georg Thieme Verlag KG Stuttgart · New York</rights><rights>2015 INIST-CNRS</rights><rights>Georg Thieme Verlag KG Stuttgart.New York.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-a431be5ca5a0778527cf7a4e44256d66a12d55a6444571fb19e7913363710d6d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0029-1243256.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-0029-1243256$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,778,782,3006,3007,27907,27908,54542,54543</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22464964$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20157874$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamin, C.</creatorcontrib><creatorcontrib>Oliveira, J.</creatorcontrib><creatorcontrib>Meckel, Y.</creatorcontrib><creatorcontrib>Eynon, N.</creatorcontrib><creatorcontrib>Sagiv, M.</creatorcontrib><creatorcontrib>Ayalon, M.</creatorcontrib><creatorcontrib>Alves, A. J.</creatorcontrib><creatorcontrib>Duarte, J. A.</creatorcontrib><title>CK-MM Gene Polymorphism Does not Influence the Blood CK Activity Levels After Exhaustive Eccentric Exercise</title><title>International journal of sports medicine</title><addtitle>Int J Sports Med</addtitle><description>Abstract
Gene variants, such as creatine kinase (CK) polymorphisms, have been suggested to explain the inter-individual blood CK response to eccentric exercise. However, since this association is still doubtful, the purpose of this study was to analyse the relationship between the magnitudes of the CK response to exercise with the occurrence of muscle CK-MM NcoI polymorphism in young healthy subjects. Blood CK activity was assessed in 70 subjects immediately before and 3, 24, 48, 72, 96, 120, 168 h after strenuous eccentric exercise. Based on the amount of CK release by each subject, the sample was distributed in quartiles and the genotype and allele frequency distribution was compared among quartiles. Despite the inter-individual variability of CK response observed between subjects, there were no differences in genotype and allele frequencies among quartiles. The results allowed us to conclude that CK response after exhaustive eccentric exercise is not associated with CK-MM Ncol polymorphism.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Creatine Kinase - blood</subject><subject>Creatine Kinase - genetics</subject><subject>Creatine Kinase, MM Form - blood</subject><subject>Creatine Kinase, MM Form - genetics</subject><subject>Exercise - physiology</subject><subject>Exercise Tolerance - genetics</subject><subject>Exercise Tolerance - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics & Molecular Biology</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Motor Activity</subject><subject>Muscle, Skeletal - physiology</subject><subject>Polymorphism, Genetic</subject><subject>Sex Factors</subject><subject>Time Factors</subject><subject>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><issn>0172-4622</issn><issn>1439-3964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1vEzEQxS0EomnhyhH5gji5-GNs7x5DGkrVVHCAs-V4Z5Utu-tg71bkv8dVUjghTiPN_GZG7z1C3gh-KbjWHzLjXNZMSFBSm2dkIUDVTNUGnpMFF1YyMFKekfOc7zkXUAv1kpxJLrStLCzIj9Utu7uj1zgi_Rr7wxDTftflgV5FzHSME70Z237GMSCddkg_9jE2dHVLl2HqHrrpQDf4gH2my3bCRNe_dn7OZYJ0HQKOU-pCaWIKXcZX5EXr-4yvT_WCfP-0_rb6zDZfrm9Wyw0LoGBiHpTYog5ee25tpaUNrfWAAEVhY4wXstHaGwDQVrRbUaMtspRRVvDGNOqCvD_e3af4c8Y8uaHLAfvejxjn7GxZrKzi8H9SKctFVVeFvDySIcWcE7Zun7rBp4MT3D0m4bJ7TMKdkigLb0-n5-2AzR_8yfoCvDsBPgfft8mPxaS_nAQDJcbCsSM37Toc0N3HOY3Fvn89_g1YhpyA</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Yamin, C.</creator><creator>Oliveira, J.</creator><creator>Meckel, Y.</creator><creator>Eynon, N.</creator><creator>Sagiv, M.</creator><creator>Ayalon, M.</creator><creator>Alves, A. J.</creator><creator>Duarte, J. A.</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TS</scope></search><sort><creationdate>20100301</creationdate><title>CK-MM Gene Polymorphism Does not Influence the Blood CK Activity Levels After Exhaustive Eccentric Exercise</title><author>Yamin, C. ; Oliveira, J. ; Meckel, Y. ; Eynon, N. ; Sagiv, M. ; Ayalon, M. ; Alves, A. J. ; Duarte, J. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-a431be5ca5a0778527cf7a4e44256d66a12d55a6444571fb19e7913363710d6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Creatine Kinase - blood</topic><topic>Creatine Kinase - genetics</topic><topic>Creatine Kinase, MM Form - blood</topic><topic>Creatine Kinase, MM Form - genetics</topic><topic>Exercise - physiology</topic><topic>Exercise Tolerance - genetics</topic><topic>Exercise Tolerance - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics & Molecular Biology</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Motor Activity</topic><topic>Muscle, Skeletal - physiology</topic><topic>Polymorphism, Genetic</topic><topic>Sex Factors</topic><topic>Time Factors</topic><topic>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamin, C.</creatorcontrib><creatorcontrib>Oliveira, J.</creatorcontrib><creatorcontrib>Meckel, Y.</creatorcontrib><creatorcontrib>Eynon, N.</creatorcontrib><creatorcontrib>Sagiv, M.</creatorcontrib><creatorcontrib>Ayalon, M.</creatorcontrib><creatorcontrib>Alves, A. J.</creatorcontrib><creatorcontrib>Duarte, J. 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A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CK-MM Gene Polymorphism Does not Influence the Blood CK Activity Levels After Exhaustive Eccentric Exercise</atitle><jtitle>International journal of sports medicine</jtitle><addtitle>Int J Sports Med</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>31</volume><issue>3</issue><spage>213</spage><epage>217</epage><pages>213-217</pages><issn>0172-4622</issn><eissn>1439-3964</eissn><coden>IJSMDA</coden><abstract>Abstract
Gene variants, such as creatine kinase (CK) polymorphisms, have been suggested to explain the inter-individual blood CK response to eccentric exercise. However, since this association is still doubtful, the purpose of this study was to analyse the relationship between the magnitudes of the CK response to exercise with the occurrence of muscle CK-MM NcoI polymorphism in young healthy subjects. Blood CK activity was assessed in 70 subjects immediately before and 3, 24, 48, 72, 96, 120, 168 h after strenuous eccentric exercise. Based on the amount of CK release by each subject, the sample was distributed in quartiles and the genotype and allele frequency distribution was compared among quartiles. Despite the inter-individual variability of CK response observed between subjects, there were no differences in genotype and allele frequencies among quartiles. The results allowed us to conclude that CK response after exhaustive eccentric exercise is not associated with CK-MM Ncol polymorphism.</abstract><cop>Stuttgart</cop><pub>Thieme</pub><pmid>20157874</pmid><doi>10.1055/s-0029-1243256</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Biological and medical sciences Biomarkers Creatine Kinase - blood Creatine Kinase - genetics Creatine Kinase, MM Form - blood Creatine Kinase, MM Form - genetics Exercise - physiology Exercise Tolerance - genetics Exercise Tolerance - physiology Female Fundamental and applied biological sciences. Psychology Genetics & Molecular Biology Genotype Humans Male Motor Activity Muscle, Skeletal - physiology Polymorphism, Genetic Sex Factors Time Factors Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports |
| title | CK-MM Gene Polymorphism Does not Influence the Blood CK Activity Levels After Exhaustive Eccentric Exercise |
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