Genotypic analysis of genes associated with isoniazid and ethionamide resistance in MDR-TB isolates from Thailand
Nucleotide sequences of genes conferring isoniazid resistance (katG, inhA, oxyR–ahpC and ndh) and ethionamide resistance (ethA) in 160 drug-resistant Mycobacterium tuberculosis clinical isolates from Thailand were analysed. Mutations in the katG gene were found in 129 isolates, predominantly at codo...
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| Veröffentlicht in: | Clinical microbiology and infection 2010-04, Vol.16 (4), p.396-399 |
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| creator | Boonaiam, S. Chaiprasert, A. Prammananan, T. Leechawengwongs, M. |
| description | Nucleotide sequences of genes conferring isoniazid resistance (katG, inhA, oxyR–ahpC and ndh) and ethionamide resistance (ethA) in 160 drug-resistant Mycobacterium tuberculosis clinical isolates from Thailand were analysed. Mutations in the katG gene were found in 129 isolates, predominantly at codon 315, which was mutated in 127 isolates. Twenty-two isolates had mutations in the inhA promoter and coding region. Mutations in the oxyR–ahpC intergenic region and in ndh were detected in four and one isolate(s), respectively. Of 24 ethionamide-resistant isolates, 13 had mutations in the ethA gene. However, these mutations were dispersed along the entire gene, with no codon predominating significantly. |
| doi_str_mv | 10.1111/j.1469-0691.2009.02838.x |
| format | Article |
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Mutations in the katG gene were found in 129 isolates, predominantly at codon 315, which was mutated in 127 isolates. Twenty-two isolates had mutations in the inhA promoter and coding region. Mutations in the oxyR–ahpC intergenic region and in ndh were detected in four and one isolate(s), respectively. Of 24 ethionamide-resistant isolates, 13 had mutations in the ethA gene. However, these mutations were dispersed along the entire gene, with no codon predominating significantly.</description><identifier>ISSN: 1198-743X</identifier><identifier>EISSN: 1469-0691</identifier><identifier>DOI: 10.1111/j.1469-0691.2009.02838.x</identifier><identifier>PMID: 19486070</identifier><language>eng</language><publisher>Oxford, UK: Elsevier Ltd</publisher><subject>Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antitubercular Agents - pharmacology ; Bacterial Proteins - genetics ; Biological and medical sciences ; Catalase - genetics ; Clinical isolates ; Codons ; Drug resistance ; Drug Resistance, Multiple, Bacterial - genetics ; Ethionamide ; Ethionamide - pharmacology ; Ethionamide resistance ; Genes ; Genotype ; Infectious diseases ; Isoniazid ; Isoniazid - pharmacology ; isoniazid resistance ; katG gene ; MDR-TB ; Medical sciences ; Mutation ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - genetics ; Mycobacterium tuberculosis - isolation & purification ; Pharmacology. Drug treatments ; Promoters ; Sequence Analysis ; Thailand ; Tuberculosis, Multidrug-Resistant - diagnosis ; Tuberculosis, Multidrug-Resistant - microbiology</subject><ispartof>Clinical microbiology and infection, 2010-04, Vol.16 (4), p.396-399</ispartof><rights>2010 European Society of Clinical Infectious Diseases</rights><rights>2009 The Authors. 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Mutations in the katG gene were found in 129 isolates, predominantly at codon 315, which was mutated in 127 isolates. Twenty-two isolates had mutations in the inhA promoter and coding region. Mutations in the oxyR–ahpC intergenic region and in ndh were detected in four and one isolate(s), respectively. Of 24 ethionamide-resistant isolates, 13 had mutations in the ethA gene. However, these mutations were dispersed along the entire gene, with no codon predominating significantly.</description><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antitubercular Agents - pharmacology</subject><subject>Bacterial Proteins - genetics</subject><subject>Biological and medical sciences</subject><subject>Catalase - genetics</subject><subject>Clinical isolates</subject><subject>Codons</subject><subject>Drug resistance</subject><subject>Drug Resistance, Multiple, Bacterial - genetics</subject><subject>Ethionamide</subject><subject>Ethionamide - pharmacology</subject><subject>Ethionamide resistance</subject><subject>Genes</subject><subject>Genotype</subject><subject>Infectious diseases</subject><subject>Isoniazid</subject><subject>Isoniazid - pharmacology</subject><subject>isoniazid resistance</subject><subject>katG gene</subject><subject>MDR-TB</subject><subject>Medical sciences</subject><subject>Mutation</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - genetics</subject><subject>Mycobacterium tuberculosis - isolation & purification</subject><subject>Pharmacology. Drug treatments</subject><subject>Promoters</subject><subject>Sequence Analysis</subject><subject>Thailand</subject><subject>Tuberculosis, Multidrug-Resistant - diagnosis</subject><subject>Tuberculosis, Multidrug-Resistant - microbiology</subject><issn>1198-743X</issn><issn>1469-0691</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV2L1DAUhoso7of-BQmI7FVr2qRpcuGFO66rMIsgI3gX0uTUydA2szkdd8dfb-oMK3iz5iaBPO_JyXmyjJS0KNN6uylKLlROhSqLilJV0EoyWdw_yU4fLp6mc6lk3nD2_SQ7Q9xQSivG-PPspFRcCtrQ0-z2GsYw7bfeEjOafo8eSejIDxgBiUEM1psJHLnz05p4DKM3v7xLrCMwrX0YzeAdkAgpOJnRAvEjufnwNV9dznifwki6GAayWhvfp9yL7FlneoSXx_08-_bxarX4lC-_XH9evF_mVrAmtS065Zy0vG2hKl3DZOtqY13q23amFYZJ5kTdyqah0jpKma077qgC0ZkaJDvPLg51tzHc7gAnPXi00KceIOxQN5zXUiiqHicZa9LkxFzz9T_kJuximhvqsua1qkRN60TJA2VjQIzQ6W30g4l7XVI9-9MbPWvSsyY9-9N__On7FH11fGDXDuD-Bo_CEvDmCBi0pu9imrnHB66quGKMVYl7d-DufA_7_25AL5Y38ynlLw95SIp-eogarYfk1_kIdtIu-Md_8xtMb8we</recordid><startdate>201004</startdate><enddate>201004</enddate><creator>Boonaiam, S.</creator><creator>Chaiprasert, A.</creator><creator>Prammananan, T.</creator><creator>Leechawengwongs, M.</creator><general>Elsevier Ltd</general><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201004</creationdate><title>Genotypic analysis of genes associated with isoniazid and ethionamide resistance in MDR-TB isolates from Thailand</title><author>Boonaiam, S. ; Chaiprasert, A. ; Prammananan, T. ; Leechawengwongs, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6378-76f9dd8c4bbe21d738bd5acd860cfab6a383d65b87708cd003c5f4d09e6fa5e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antitubercular Agents - pharmacology</topic><topic>Bacterial Proteins - genetics</topic><topic>Biological and medical sciences</topic><topic>Catalase - genetics</topic><topic>Clinical isolates</topic><topic>Codons</topic><topic>Drug resistance</topic><topic>Drug Resistance, Multiple, Bacterial - genetics</topic><topic>Ethionamide</topic><topic>Ethionamide - pharmacology</topic><topic>Ethionamide resistance</topic><topic>Genes</topic><topic>Genotype</topic><topic>Infectious diseases</topic><topic>Isoniazid</topic><topic>Isoniazid - pharmacology</topic><topic>isoniazid resistance</topic><topic>katG gene</topic><topic>MDR-TB</topic><topic>Medical sciences</topic><topic>Mutation</topic><topic>Mycobacterium tuberculosis</topic><topic>Mycobacterium tuberculosis - genetics</topic><topic>Mycobacterium tuberculosis - isolation & purification</topic><topic>Pharmacology. Drug treatments</topic><topic>Promoters</topic><topic>Sequence Analysis</topic><topic>Thailand</topic><topic>Tuberculosis, Multidrug-Resistant - diagnosis</topic><topic>Tuberculosis, Multidrug-Resistant - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boonaiam, S.</creatorcontrib><creatorcontrib>Chaiprasert, A.</creatorcontrib><creatorcontrib>Prammananan, T.</creatorcontrib><creatorcontrib>Leechawengwongs, M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical microbiology and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boonaiam, S.</au><au>Chaiprasert, A.</au><au>Prammananan, T.</au><au>Leechawengwongs, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genotypic analysis of genes associated with isoniazid and ethionamide resistance in MDR-TB isolates from Thailand</atitle><jtitle>Clinical microbiology and infection</jtitle><addtitle>Clin Microbiol Infect</addtitle><date>2010-04</date><risdate>2010</risdate><volume>16</volume><issue>4</issue><spage>396</spage><epage>399</epage><pages>396-399</pages><issn>1198-743X</issn><eissn>1469-0691</eissn><abstract>Nucleotide sequences of genes conferring isoniazid resistance (katG, inhA, oxyR–ahpC and ndh) and ethionamide resistance (ethA) in 160 drug-resistant Mycobacterium tuberculosis clinical isolates from Thailand were analysed. Mutations in the katG gene were found in 129 isolates, predominantly at codon 315, which was mutated in 127 isolates. Twenty-two isolates had mutations in the inhA promoter and coding region. Mutations in the oxyR–ahpC intergenic region and in ndh were detected in four and one isolate(s), respectively. Of 24 ethionamide-resistant isolates, 13 had mutations in the ethA gene. However, these mutations were dispersed along the entire gene, with no codon predominating significantly.</abstract><cop>Oxford, UK</cop><pub>Elsevier Ltd</pub><pmid>19486070</pmid><doi>10.1111/j.1469-0691.2009.02838.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical microbiology and infection, 2010-04, Vol.16 (4), p.396-399 |
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| subjects | Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antitubercular Agents - pharmacology Bacterial Proteins - genetics Biological and medical sciences Catalase - genetics Clinical isolates Codons Drug resistance Drug Resistance, Multiple, Bacterial - genetics Ethionamide Ethionamide - pharmacology Ethionamide resistance Genes Genotype Infectious diseases Isoniazid Isoniazid - pharmacology isoniazid resistance katG gene MDR-TB Medical sciences Mutation Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification Pharmacology. Drug treatments Promoters Sequence Analysis Thailand Tuberculosis, Multidrug-Resistant - diagnosis Tuberculosis, Multidrug-Resistant - microbiology |
| title | Genotypic analysis of genes associated with isoniazid and ethionamide resistance in MDR-TB isolates from Thailand |
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