Development and degeneration of hearing in the c57/b16 mouse: Relation of electrophysiologic responses from the round window and cochlear nucleus to cochlear anatomy and behavioral responses

In disorders of the auditory organ associated with hearing loss, a correlation of the anatomical, behavioral and electrophysiological studies furnishes the investigator several parameters of study to better comprehend the hearing mechanism and the various anatomical structural dysfunctions that rela...

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Veröffentlicht in:The Laryngoscope 1979-01, Vol.89 (1), p.1-15
1. Verfasser: Mikaelian, Diran O.
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container_title The Laryngoscope
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description In disorders of the auditory organ associated with hearing loss, a correlation of the anatomical, behavioral and electrophysiological studies furnishes the investigator several parameters of study to better comprehend the hearing mechanism and the various anatomical structural dysfunctions that relate to the hearing loss. Mice are interesting to study because they carry several types of genes for hereditary deafness. Until recently, it was very difficult to train mice for behavioral hearing threshold testing; however, having developed such a method, the next step was to study the normal mice in these three parameters and extend the studies to mice with hereditary hearing loss. The type of mouse studied in this research was the C57/b16 strain which carries such a gene. The results of the studies indicate that the results of the behavioral and electrophysiological studies relate well to each other, and that light microscopic studies (if taken alone) do not furnish us with the actual functional capability of the structures of the inner ear. It is recommended (and it would be most valuable) that efforts should be made to collect and study human temporal bones with all three parameters of study for a better understanding of the structures of the human inner ear. Reference is made and recommendations given as to the parameters of studies while performing human electrocochleography.
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identifier ISSN: 0023-852X
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source MEDLINE; Journals@Ovid Complete
subjects Acoustic Stimulation
Action Potentials
Aging
Animals
Cochlea - physiopathology
Cochlear Nerve - physiopathology
Ear, Inner - pathology
Electrophysiology
Hearing
Hearing Disorders - pathology
Hearing Disorders - physiopathology
Mice
Mice, Inbred C57BL
Neural Pathways
Organ of Corti - pathology
Pons
Round Window, Ear - physiopathology
title Development and degeneration of hearing in the c57/b16 mouse: Relation of electrophysiologic responses from the round window and cochlear nucleus to cochlear anatomy and behavioral responses
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