In vitro functional studies of mononuclear cells in patients with CLL. Evidence for functionally normal T lymphocytes and monocytes and abnormal B lymphocytes

In vitro functional studies of mononuclear cells from 34 patients with B‐cell type CLL were investigated and the results of these studies were as follows: 1 The T lymphocytes from patients with CLL were capable of responding normally to PHA or PWM, of inducing allogeneic normal B lymphocytes to resp...

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Veröffentlicht in:Cancer 1979-01, Vol.43 (1), p.109-117
Hauptverfasser: Han, Tin, Dadey, Barbara
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description In vitro functional studies of mononuclear cells from 34 patients with B‐cell type CLL were investigated and the results of these studies were as follows: 1 The T lymphocytes from patients with CLL were capable of responding normally to PHA or PWM, of inducing allogeneic normal B lymphocytes to respond to these mitogens and of stimulating normally to allogeneic lymphocytes in “one‐way” mixed lymphocyte reaction; 2 The monocytes from these patients were capable of enhancing the T lymphocyte response to mitogens and of stimulating normally to allogeneic lymphocytes; and 3 The leukemic B lymphocytes were incapable of responding to mitogens even in the presence of normal T lymphocytes and their enhancer cell activity on T lymphocyte response or their stimulating capacity on allogeneic lymphocytes was depressed. These observations suggest that the T lymphocytes and monocytes from patients with CLL are functionally normal while the leukemic B lymphocytes from these patients are functionally abnormal.
doi_str_mv 10.1002/1097-0142(197901)43:1<109::AID-CNCR2820430117>3.0.CO;2-G
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Evidence for functionally normal T lymphocytes and monocytes and abnormal B lymphocytes</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1979-01</date><risdate>1979</risdate><volume>43</volume><issue>1</issue><spage>109</spage><epage>117</epage><pages>109-117</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>In vitro functional studies of mononuclear cells from 34 patients with B‐cell type CLL were investigated and the results of these studies were as follows: 1 The T lymphocytes from patients with CLL were capable of responding normally to PHA or PWM, of inducing allogeneic normal B lymphocytes to respond to these mitogens and of stimulating normally to allogeneic lymphocytes in “one‐way” mixed lymphocyte reaction; 2 The monocytes from these patients were capable of enhancing the T lymphocyte response to mitogens and of stimulating normally to allogeneic lymphocytes; and 3 The leukemic B lymphocytes were incapable of responding to mitogens even in the presence of normal T lymphocytes and their enhancer cell activity on T lymphocyte response or their stimulating capacity on allogeneic lymphocytes was depressed. 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subjects Adult
Aged
B-Lymphocytes - immunology
Female
Humans
In Vitro Techniques
Leukemia, Lymphoid - immunology
Lymphocyte Activation
Lymphocyte Cooperation
Lymphocyte Culture Test, Mixed
Male
Middle Aged
Mitogens - pharmacology
Monocytes - immunology
Phytohemagglutinins - pharmacology
T-Lymphocytes - immunology
title In vitro functional studies of mononuclear cells in patients with CLL. Evidence for functionally normal T lymphocytes and monocytes and abnormal B lymphocytes
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