Rate of metabolism of norethisterone in women from different populations

The rate of metabolism of orally administered norethisterone was compared in fourteen centres by measuring plasma levels of the steroid by radioimmunoassay at varying times after oral administration of a 1 mg dose. The inter-centre differences were of the same order as the intra-centre differences....

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Veröffentlicht in:Contraception (Stoneham) 1979, Vol.19 (1), p.39-45
Hauptverfasser: Fotherby, K., Shrimanker, K., Abdel-Rahman, H.A., Toppozada, H.K., de Souza, J.C., Coutinho, E.M., Koetsawang, S., Nukulkarn, P., Sheth, U.K., Mapa, M.K., Gopalan, S., Plunkett, E.R., Brenner, P.F., Hickey, M.V., Grech, E.S., Lichtenberg, R., Gual, C., Molina, R., Gomez-Rogers, C., Kwon, E., Kim, S.W., Chan, T., Ratnam, S.S., Landgren, B.M., Shearman, R.P.
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container_end_page 45
container_issue 1
container_start_page 39
container_title Contraception (Stoneham)
container_volume 19
creator Fotherby, K.
Shrimanker, K.
Abdel-Rahman, H.A.
Toppozada, H.K.
de Souza, J.C.
Coutinho, E.M.
Koetsawang, S.
Nukulkarn, P.
Sheth, U.K.
Mapa, M.K.
Gopalan, S.
Plunkett, E.R.
Brenner, P.F.
Hickey, M.V.
Grech, E.S.
Lichtenberg, R.
Gual, C.
Molina, R.
Gomez-Rogers, C.
Kwon, E.
Kim, S.W.
Chan, T.
Ratnam, S.S.
Landgren, B.M.
Shearman, R.P.
description The rate of metabolism of orally administered norethisterone was compared in fourteen centres by measuring plasma levels of the steroid by radioimmunoassay at varying times after oral administration of a 1 mg dose. The inter-centre differences were of the same order as the intra-centre differences. Variations in metabolism appeared not to be due to variations in body size.
doi_str_mv 10.1016/S0010-7824(79)80007-4
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subjects Adult
Female
Half-Life
Humans
Norethindrone - blood
Norethindrone - metabolism
title Rate of metabolism of norethisterone in women from different populations
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