Antiscorbutic activity of ascorbic acid phosphate in the rhesus monkey and the guinea pig
Extract: Rhesus monkeys fed an ascorbic acid-free, purified liquid diet, developed scurvy in 70 to 105 days. Oral administration of either 10 mg/kg body weight of ascorbic acid or an equimolar amount of the magnesium salt of l-ascorbic acid phosphate cured all symptoms of scurvy. Similarly, oral adm...
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| Veröffentlicht in: | The American journal of clinical nutrition 1979-02, Vol.32 (2), p.325-331 |
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| container_end_page | 331 |
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| container_issue | 2 |
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| container_title | The American journal of clinical nutrition |
| container_volume | 32 |
| creator | Machlin, L.J Garcia, F Kuenzig, W Brin, M |
| description | Extract: Rhesus monkeys fed an ascorbic acid-free, purified liquid diet, developed scurvy in 70 to 105 days. Oral administration of either 10 mg/kg body weight of ascorbic acid or an equimolar amount of the magnesium salt of l-ascorbic acid phosphate cured all symptoms of scurvy. Similarly, oral administration of l-ascorbic acid phosphate cured all symptoms of scurvy in the guinea pig and resulted in liver ascorbate levels equal to those of animals fed ascorbic acid. It is concluded that ascorbic acid phosphate is a readily available source of ascorbic acid activity in vivo. |
| doi_str_mv | 10.1093/ajcn/32.2.325 |
| format | Article |
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Oral administration of either 10 mg/kg body weight of ascorbic acid or an equimolar amount of the magnesium salt of l-ascorbic acid phosphate cured all symptoms of scurvy. Similarly, oral administration of l-ascorbic acid phosphate cured all symptoms of scurvy in the guinea pig and resulted in liver ascorbate levels equal to those of animals fed ascorbic acid. It is concluded that ascorbic acid phosphate is a readily available source of ascorbic acid activity in vivo.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/32.2.325</identifier><identifier>PMID: 105621</identifier><language>eng</language><publisher>United States</publisher><subject>animal experimentation ; Animals ; ascorbic acid ; Ascorbic Acid - analogs & derivatives ; Ascorbic Acid - metabolism ; Ascorbic Acid - therapeutic use ; Body Weight - drug effects ; Guinea Pigs ; Haplorhini ; hematologic tests ; Liver - metabolism ; Macaca mulatta ; Male ; Organophosphorus Compounds - therapeutic use ; phosphates ; scurvy ; Scurvy - drug therapy ; Species Specificity ; Structure-Activity Relationship ; Vitamin therapy</subject><ispartof>The American journal of clinical nutrition, 1979-02, Vol.32 (2), p.325-331</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3315-727004a3d224f8319dcaa30bfc98fba9de5bdcab9c0cbf3999c68216d52d179b3</citedby><cites>FETCH-LOGICAL-c3315-727004a3d224f8319dcaa30bfc98fba9de5bdcab9c0cbf3999c68216d52d179b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/105621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Machlin, L.J</creatorcontrib><creatorcontrib>Garcia, F</creatorcontrib><creatorcontrib>Kuenzig, W</creatorcontrib><creatorcontrib>Brin, M</creatorcontrib><title>Antiscorbutic activity of ascorbic acid phosphate in the rhesus monkey and the guinea pig</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>Extract: Rhesus monkeys fed an ascorbic acid-free, purified liquid diet, developed scurvy in 70 to 105 days. 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It is concluded that ascorbic acid phosphate is a readily available source of ascorbic acid activity in vivo.</description><subject>animal experimentation</subject><subject>Animals</subject><subject>ascorbic acid</subject><subject>Ascorbic Acid - analogs & derivatives</subject><subject>Ascorbic Acid - metabolism</subject><subject>Ascorbic Acid - therapeutic use</subject><subject>Body Weight - drug effects</subject><subject>Guinea Pigs</subject><subject>Haplorhini</subject><subject>hematologic tests</subject><subject>Liver - metabolism</subject><subject>Macaca mulatta</subject><subject>Male</subject><subject>Organophosphorus Compounds - therapeutic use</subject><subject>phosphates</subject><subject>scurvy</subject><subject>Scurvy - drug therapy</subject><subject>Species Specificity</subject><subject>Structure-Activity Relationship</subject><subject>Vitamin therapy</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkL1rwzAQxUXpV5p27Faopm5OJJ1lW2MI_YJAhzZDJyHLcqw0sVzJLuS_r5J0KBx38HuPg_cQuqVkQomAqVrrdgpswibA-AkaUQFFAozkp2hECGGJoBm_RFchrAmhLC2yC3ROCc8YHaHPWdvboJ0vh95qrHRvf2y_w67G6oAP0Fa4a1zoGtUbbFvcNwb7xoQh4K1rv8wOq7Y60NVgW6NwZ1fX6KxWm2Bu_u4YLZ8eP-YvyeLt-XU-WyQagPIkZzkhqYKKsbQugIpKKwWkrLUo6lKJyvAyolJoossahBA6KxjNKs4qmosSxujh-Lfz7nswoZfbGMhsNqo1bggyT1OAGDoak6NRexeCN7XsvN0qv5OUyH2Tct-kBCZZXDz67_4eD-XWVP_c--qifH-Ua-WkWnkb5PKdEQpxOGRcwC9Q1HlH</recordid><startdate>197902</startdate><enddate>197902</enddate><creator>Machlin, L.J</creator><creator>Garcia, F</creator><creator>Kuenzig, W</creator><creator>Brin, M</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197902</creationdate><title>Antiscorbutic activity of ascorbic acid phosphate in the rhesus monkey and the guinea pig</title><author>Machlin, L.J ; Garcia, F ; Kuenzig, W ; Brin, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3315-727004a3d224f8319dcaa30bfc98fba9de5bdcab9c0cbf3999c68216d52d179b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>animal experimentation</topic><topic>Animals</topic><topic>ascorbic acid</topic><topic>Ascorbic Acid - analogs & derivatives</topic><topic>Ascorbic Acid - metabolism</topic><topic>Ascorbic Acid - therapeutic use</topic><topic>Body Weight - drug effects</topic><topic>Guinea Pigs</topic><topic>Haplorhini</topic><topic>hematologic tests</topic><topic>Liver - metabolism</topic><topic>Macaca mulatta</topic><topic>Male</topic><topic>Organophosphorus Compounds - therapeutic use</topic><topic>phosphates</topic><topic>scurvy</topic><topic>Scurvy - drug therapy</topic><topic>Species Specificity</topic><topic>Structure-Activity Relationship</topic><topic>Vitamin therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Machlin, L.J</creatorcontrib><creatorcontrib>Garcia, F</creatorcontrib><creatorcontrib>Kuenzig, W</creatorcontrib><creatorcontrib>Brin, M</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Machlin, L.J</au><au>Garcia, F</au><au>Kuenzig, W</au><au>Brin, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiscorbutic activity of ascorbic acid phosphate in the rhesus monkey and the guinea pig</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1979-02</date><risdate>1979</risdate><volume>32</volume><issue>2</issue><spage>325</spage><epage>331</epage><pages>325-331</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><abstract>Extract: Rhesus monkeys fed an ascorbic acid-free, purified liquid diet, developed scurvy in 70 to 105 days. 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| fulltext | fulltext |
| identifier | ISSN: 0002-9165 |
| ispartof | The American journal of clinical nutrition, 1979-02, Vol.32 (2), p.325-331 |
| issn | 0002-9165 1938-3207 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | animal experimentation Animals ascorbic acid Ascorbic Acid - analogs & derivatives Ascorbic Acid - metabolism Ascorbic Acid - therapeutic use Body Weight - drug effects Guinea Pigs Haplorhini hematologic tests Liver - metabolism Macaca mulatta Male Organophosphorus Compounds - therapeutic use phosphates scurvy Scurvy - drug therapy Species Specificity Structure-Activity Relationship Vitamin therapy |
| title | Antiscorbutic activity of ascorbic acid phosphate in the rhesus monkey and the guinea pig |
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