Sister chromatid exchanges and chromosomes in chronic myelogenous leukemia and cancer families
Spontaneouas sister chromatid exchanges and banded karyotypes were studied in blood lymphocytes from 96 individuals: seven patients with chronic myelogenous leukemia, 15 normal controls, and five “cancer families” comprising 12 cancer patients, 40 tumor‐free blood relatives and 22 spouses. The famil...
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| Veröffentlicht in: | International journal of cancer 1979-01, Vol.23 (1), p.8-13 |
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| container_title | International journal of cancer |
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| creator | Cheng, Wind‐Show Mulvihill, John J. Greene, Mark H. Pickle, Linda W. Tsai, Shien Whang‐Peng, Jacqueline |
| description | Spontaneouas sister chromatid exchanges and banded karyotypes were studied in blood lymphocytes from 96 individuals: seven patients with chronic myelogenous leukemia, 15 normal controls, and five “cancer families” comprising 12 cancer patients, 40 tumor‐free blood relatives and 22 spouses. The families had: malignant melanoma; Epstein‐Barr virus‐associated malignancies and a birth defect syndrome; non‐Hodgkin lymphoma and diverse carcinomas; Hodgkin's lymphoma and adenocarcinomas; and acute myelogenous leukemia. In addition to the Philadelphia chromosome in chronic myelogenous leukemia patients, karyotypic abnormalities, especially breaks and fragments, were found in 29% of cancer family members, but were inconsistent and usually attributable to radiotherapy. Mean sister chromatid exchange values were normal in chronic myelogenous leukemia, but low (by t‐test) in tumor patients and their blood relatives in cancer‐prone families. In tumor patients, mean sister chromatid exchange levels fell as age increased. After adjusting for this age effect, no significant differences remained among groups. In patients at high risk of cancer (because they have chronic myelogenous leukemia or a strong family history of cancer), spontaneous sister chromatid exchange rates were not a marker of cancer risk. |
| doi_str_mv | 10.1002/ijc.2910230103 |
| format | Article |
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The families had: malignant melanoma; Epstein‐Barr virus‐associated malignancies and a birth defect syndrome; non‐Hodgkin lymphoma and diverse carcinomas; Hodgkin's lymphoma and adenocarcinomas; and acute myelogenous leukemia. In addition to the Philadelphia chromosome in chronic myelogenous leukemia patients, karyotypic abnormalities, especially breaks and fragments, were found in 29% of cancer family members, but were inconsistent and usually attributable to radiotherapy. Mean sister chromatid exchange values were normal in chronic myelogenous leukemia, but low (by t‐test) in tumor patients and their blood relatives in cancer‐prone families. In tumor patients, mean sister chromatid exchange levels fell as age increased. After adjusting for this age effect, no significant differences remained among groups. 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The families had: malignant melanoma; Epstein‐Barr virus‐associated malignancies and a birth defect syndrome; non‐Hodgkin lymphoma and diverse carcinomas; Hodgkin's lymphoma and adenocarcinomas; and acute myelogenous leukemia. In addition to the Philadelphia chromosome in chronic myelogenous leukemia patients, karyotypic abnormalities, especially breaks and fragments, were found in 29% of cancer family members, but were inconsistent and usually attributable to radiotherapy. Mean sister chromatid exchange values were normal in chronic myelogenous leukemia, but low (by t‐test) in tumor patients and their blood relatives in cancer‐prone families. In tumor patients, mean sister chromatid exchange levels fell as age increased. After adjusting for this age effect, no significant differences remained among groups. In patients at high risk of cancer (because they have chronic myelogenous leukemia or a strong family history of cancer), spontaneous sister chromatid exchange rates were not a marker of cancer risk.</description><subject>Adenocarcinoma - genetics</subject><subject>Adult</subject><subject>Aged</subject><subject>Chromatids - ultrastructure</subject><subject>Chromosomes, Human, 21-22 and Y</subject><subject>Female</subject><subject>Hodgkin Disease - genetics</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Leukemia, Myeloid - genetics</subject><subject>Lymphocytes - ultrastructure</subject><subject>Lymphoma - genetics</subject><subject>Male</subject><subject>Melanoma - genetics</subject><subject>Middle Aged</subject><subject>Neoplasms - genetics</subject><subject>Pedigree</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLtPwzAQhy3EqxRWJoZMbCl3dl4eUcWjqBIDsGI5jt26xAnEjaD_PYZUwMZ0urvvPp1-hJwiTBCAXtiVmlCOQBkgsB0yQuB5DBTTXTIKAMQ5suyQHHm_AkBMITkg-7SgNMcReX6wfq27SC271sm1rSL9oZayWWgfyaYa5q1vXeht8902VkVuo-t2oZu291Gt-xftrBx42aigM9LZ2mp_TPaMrL0-2dYxebq-epzexvP7m9n0ch4rxjgLHyqaZAwV4wkYWamS0zTFsszKCnla5AUvkyJjzJRVhaiNBI4MjCmQc8CSjcn54H3t2rde-7Vw1itd17LR4UeRJwlAnhcBnAyg6lrvO23Ea2ed7DYCQXzlKUKe4jfPcHC2Nfel09UPPgQY1nxYv9tab_6Ridnd9I_6EzdCgb8</recordid><startdate>19790115</startdate><enddate>19790115</enddate><creator>Cheng, Wind‐Show</creator><creator>Mulvihill, John J.</creator><creator>Greene, Mark H.</creator><creator>Pickle, Linda W.</creator><creator>Tsai, Shien</creator><creator>Whang‐Peng, Jacqueline</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19790115</creationdate><title>Sister chromatid exchanges and chromosomes in chronic myelogenous leukemia and cancer families</title><author>Cheng, Wind‐Show ; Mulvihill, John J. ; Greene, Mark H. ; Pickle, Linda W. ; Tsai, Shien ; Whang‐Peng, Jacqueline</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3393-71c24631c3940fadcb92551bb6bd1958789b48633fbdd11efa09130ff819901b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adult</topic><topic>Aged</topic><topic>Chromatids - ultrastructure</topic><topic>Chromosomes, Human, 21-22 and Y</topic><topic>Female</topic><topic>Hodgkin Disease - genetics</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Leukemia, Myeloid - genetics</topic><topic>Lymphocytes - ultrastructure</topic><topic>Lymphoma - genetics</topic><topic>Male</topic><topic>Melanoma - genetics</topic><topic>Middle Aged</topic><topic>Neoplasms - genetics</topic><topic>Pedigree</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Wind‐Show</creatorcontrib><creatorcontrib>Mulvihill, John J.</creatorcontrib><creatorcontrib>Greene, Mark H.</creatorcontrib><creatorcontrib>Pickle, Linda W.</creatorcontrib><creatorcontrib>Tsai, Shien</creatorcontrib><creatorcontrib>Whang‐Peng, Jacqueline</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Wind‐Show</au><au>Mulvihill, John J.</au><au>Greene, Mark H.</au><au>Pickle, Linda W.</au><au>Tsai, Shien</au><au>Whang‐Peng, Jacqueline</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sister chromatid exchanges and chromosomes in chronic myelogenous leukemia and cancer families</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>1979-01-15</date><risdate>1979</risdate><volume>23</volume><issue>1</issue><spage>8</spage><epage>13</epage><pages>8-13</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><abstract>Spontaneouas sister chromatid exchanges and banded karyotypes were studied in blood lymphocytes from 96 individuals: seven patients with chronic myelogenous leukemia, 15 normal controls, and five “cancer families” comprising 12 cancer patients, 40 tumor‐free blood relatives and 22 spouses. The families had: malignant melanoma; Epstein‐Barr virus‐associated malignancies and a birth defect syndrome; non‐Hodgkin lymphoma and diverse carcinomas; Hodgkin's lymphoma and adenocarcinomas; and acute myelogenous leukemia. In addition to the Philadelphia chromosome in chronic myelogenous leukemia patients, karyotypic abnormalities, especially breaks and fragments, were found in 29% of cancer family members, but were inconsistent and usually attributable to radiotherapy. Mean sister chromatid exchange values were normal in chronic myelogenous leukemia, but low (by t‐test) in tumor patients and their blood relatives in cancer‐prone families. In tumor patients, mean sister chromatid exchange levels fell as age increased. After adjusting for this age effect, no significant differences remained among groups. 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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adenocarcinoma - genetics Adult Aged Chromatids - ultrastructure Chromosomes, Human, 21-22 and Y Female Hodgkin Disease - genetics Humans Karyotyping Leukemia, Myeloid - genetics Lymphocytes - ultrastructure Lymphoma - genetics Male Melanoma - genetics Middle Aged Neoplasms - genetics Pedigree |
| title | Sister chromatid exchanges and chromosomes in chronic myelogenous leukemia and cancer families |
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