Membrane alterations in irreversibly sickled cells: Hemoglobin-membrane interaction

Irreversibly sickled cells (ISCs) are sickle erythrocytes which retain bipolar enlongated shapes despite reoxygenation and owe their biophysical abnormalities to acquired membrane alterations. Freeze‐etched membranes both of ISCs produced in vitro and ISCs isolated in vivo reveal microbodies fixed t...

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Veröffentlicht in:	Journal of supramolecular structure 1978, Vol.9 (4), p.537-554
Hauptverfasser:	Lessin, Lawrence S., Kurantsin-Mills, Joseph, Wallas, Charles, Weems, Henri
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - blood Anemia, Sickle Cell - pathology Diphosphoglyceric Acids - blood Erythrocyte Membrane - metabolism Erythrocyte Membrane - ultrastructure Erythrocytes - metabolism Erythrocytes - ultrastructure Freeze Etching Hemoglobin A - metabolism Hemoglobin, Sickle - metabolism Humans irreversibly sickled cells membrane proteins and glycoproteins membrane-bound hemoglobin Microscopy, Electron Microscopy, Electron, Scanning Protein Binding Pyruvate Kinase - blood scanning electron micrography Sodium - blood
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