Comparison of two radioimmunoassays and a microbiologic assay for bleomycin
Recently two radioimmunoassays have been independently developed for determination of bleomycin levels. In this study these assays are compared with each other and with a standard microbiologic assay for bleomycin. Bleomycin levels were determined in serum and urine samples obtained at varying inter...
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| Veröffentlicht in: | Med. Pediatr. Oncol.; (United States) 1978, Vol.5 (1), p.213-218 |
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| container_title | Med. Pediatr. Oncol.; (United States) |
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| creator | Elson, Michael K. Oken, Martin M. Shafer, Rex B. Broughton, Alan Strong, James Braun, C. T. Crooke, Stanley T. |
| description | Recently two radioimmunoassays have been independently developed for determination of bleomycin levels. In this study these assays are compared with each other and with a standard microbiologic assay for bleomycin. Bleomycin levels were determined in serum and urine samples obtained at varying intervals following intramuscular bleomycin injection. There were systematic differences between the assays. One radioimmunoassay indicated bleomycin levels lower than the levels indicated by the microbiologic assay with serum samples. With urine samples, both radioimmunoassays indicated bleomycin levels greater than the microbiologic assay. |
| doi_str_mv | 10.1002/mpo.2950050129 |
| format | Article |
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T. ; Crooke, Stanley T.</creator><creatorcontrib>Elson, Michael K. ; Oken, Martin M. ; Shafer, Rex B. ; Broughton, Alan ; Strong, James ; Braun, C. T. ; Crooke, Stanley T. ; Veterans Administration Hospital, Minneapolis, MN</creatorcontrib><description>Recently two radioimmunoassays have been independently developed for determination of bleomycin levels. In this study these assays are compared with each other and with a standard microbiologic assay for bleomycin. Bleomycin levels were determined in serum and urine samples obtained at varying intervals following intramuscular bleomycin injection. There were systematic differences between the assays. One radioimmunoassay indicated bleomycin levels lower than the levels indicated by the microbiologic assay with serum samples. With urine samples, both radioimmunoassays indicated bleomycin levels greater than the microbiologic assay.</description><identifier>ISSN: 0098-1532</identifier><identifier>EISSN: 1096-911X</identifier><identifier>DOI: 10.1002/mpo.2950050129</identifier><identifier>PMID: 85252</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics ; ANTI-INFECTIVE AGENTS ; ANTIBIOTICS ; Antibody Specificity ; ANTIMITOTIC DRUGS ; ANTINEOPLASTIC DRUGS ; BIOASSAY ; Biological Assay ; BIOLOGICAL MATERIALS ; BIOLOGICAL WASTES ; BLEOMYCIN ; Bleomycin - analysis ; BLOOD SERUM ; BODY FLUIDS ; COBALT ISOTOPES ; Cobalt Radioisotopes ; COMPARATIVE EVALUATIONS ; DRUGS ; Humans ; IMMUNE SERUMS ; IODINE ISOTOPES ; Iodine Radioisotopes ; ISOTOPE APPLICATIONS ; ISOTOPES ; LABELLED COMPOUNDS ; MATERIALS ; microbiologic assay ; PATIENTS ; pharmacokinetics ; RADIOASSAY ; RADIOIMMUNOASSAY ; Radioimmunoassay - methods ; RADIOLOGY AND NUCLEAR MEDICINE ; Time Factors ; TRACER TECHNIQUES ; URINE ; WASTES</subject><ispartof>Med. 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T.</creatorcontrib><creatorcontrib>Crooke, Stanley T.</creatorcontrib><creatorcontrib>Veterans Administration Hospital, Minneapolis, MN</creatorcontrib><title>Comparison of two radioimmunoassays and a microbiologic assay for bleomycin</title><title>Med. Pediatr. Oncol.; (United States)</title><addtitle>Med. Pediatr. Oncol</addtitle><description>Recently two radioimmunoassays have been independently developed for determination of bleomycin levels. In this study these assays are compared with each other and with a standard microbiologic assay for bleomycin. Bleomycin levels were determined in serum and urine samples obtained at varying intervals following intramuscular bleomycin injection. There were systematic differences between the assays. One radioimmunoassay indicated bleomycin levels lower than the levels indicated by the microbiologic assay with serum samples. With urine samples, both radioimmunoassays indicated bleomycin levels greater than the microbiologic assay.</description><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics</subject><subject>ANTI-INFECTIVE AGENTS</subject><subject>ANTIBIOTICS</subject><subject>Antibody Specificity</subject><subject>ANTIMITOTIC DRUGS</subject><subject>ANTINEOPLASTIC DRUGS</subject><subject>BIOASSAY</subject><subject>Biological Assay</subject><subject>BIOLOGICAL MATERIALS</subject><subject>BIOLOGICAL WASTES</subject><subject>BLEOMYCIN</subject><subject>Bleomycin - analysis</subject><subject>BLOOD SERUM</subject><subject>BODY FLUIDS</subject><subject>COBALT ISOTOPES</subject><subject>Cobalt Radioisotopes</subject><subject>COMPARATIVE EVALUATIONS</subject><subject>DRUGS</subject><subject>Humans</subject><subject>IMMUNE SERUMS</subject><subject>IODINE ISOTOPES</subject><subject>Iodine Radioisotopes</subject><subject>ISOTOPE APPLICATIONS</subject><subject>ISOTOPES</subject><subject>LABELLED COMPOUNDS</subject><subject>MATERIALS</subject><subject>microbiologic assay</subject><subject>PATIENTS</subject><subject>pharmacokinetics</subject><subject>RADIOASSAY</subject><subject>RADIOIMMUNOASSAY</subject><subject>Radioimmunoassay - methods</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Time Factors</subject><subject>TRACER TECHNIQUES</subject><subject>URINE</subject><subject>WASTES</subject><issn>0098-1532</issn><issn>1096-911X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAURS1EBUPLlg0biwW7TP3sOC9eolEpiCkFqXzsLMexwRDHg51RmX9P2lRFrFhZT_fcK_kQ8gzYGhjjp3GX1lxJxiQDrh6QFTDVVArg60OyYky1FUjBH5Mnpfxg862wfUSOWsklX5F3mxR3JoeSRpo8na4TzaYPKcS4H5MpxRwKNWNPDY3B5tSFNKRvwdLbiPqUaTe4FA82jCfkyJuhuKd37zH59PrsavOm2l6ev9282lZWQKsqNFB7wLqrWe1dj7zHtuHK-85BYxxDgeA4OpRSgTeub5VQbS1a5Ai-9uKYvFh2U5mCLjZMzn63aRydnbRE1jBgM_RygXY5_dq7MukYinXDYEaX9kVjLVAhiBlcL-D8u1Ky83qXQzT5oIHpG8F6Fqz_Cp4Lz--W9110_T1-a3RO1ZJeh8Ed_rOlLz5c_rNcLd1QJvf7vmvyT93MVqT-8v5c1x-3F6g-o0bxB4mvlZ4</recordid><startdate>1978</startdate><enddate>1978</enddate><creator>Elson, Michael K.</creator><creator>Oken, Martin M.</creator><creator>Shafer, Rex B.</creator><creator>Broughton, Alan</creator><creator>Strong, James</creator><creator>Braun, C. T.</creator><creator>Crooke, Stanley T.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>1978</creationdate><title>Comparison of two radioimmunoassays and a microbiologic assay for bleomycin</title><author>Elson, Michael K. ; Oken, Martin M. ; Shafer, Rex B. ; Broughton, Alan ; Strong, James ; Braun, C. T. ; Crooke, Stanley T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3189-7a14f174b404fed72d78629ffbe16ae07371e27e75591faed893984387271f4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>550601 - Medicine- Unsealed Radionuclides in Diagnostics</topic><topic>ANTI-INFECTIVE AGENTS</topic><topic>ANTIBIOTICS</topic><topic>Antibody Specificity</topic><topic>ANTIMITOTIC DRUGS</topic><topic>ANTINEOPLASTIC DRUGS</topic><topic>BIOASSAY</topic><topic>Biological Assay</topic><topic>BIOLOGICAL MATERIALS</topic><topic>BIOLOGICAL WASTES</topic><topic>BLEOMYCIN</topic><topic>Bleomycin - analysis</topic><topic>BLOOD SERUM</topic><topic>BODY FLUIDS</topic><topic>COBALT ISOTOPES</topic><topic>Cobalt Radioisotopes</topic><topic>COMPARATIVE EVALUATIONS</topic><topic>DRUGS</topic><topic>Humans</topic><topic>IMMUNE SERUMS</topic><topic>IODINE ISOTOPES</topic><topic>Iodine Radioisotopes</topic><topic>ISOTOPE APPLICATIONS</topic><topic>ISOTOPES</topic><topic>LABELLED COMPOUNDS</topic><topic>MATERIALS</topic><topic>microbiologic assay</topic><topic>PATIENTS</topic><topic>pharmacokinetics</topic><topic>RADIOASSAY</topic><topic>RADIOIMMUNOASSAY</topic><topic>Radioimmunoassay - methods</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Time Factors</topic><topic>TRACER TECHNIQUES</topic><topic>URINE</topic><topic>WASTES</topic><toplevel>online_resources</toplevel><creatorcontrib>Elson, Michael K.</creatorcontrib><creatorcontrib>Oken, Martin M.</creatorcontrib><creatorcontrib>Shafer, Rex B.</creatorcontrib><creatorcontrib>Broughton, Alan</creatorcontrib><creatorcontrib>Strong, James</creatorcontrib><creatorcontrib>Braun, C. T.</creatorcontrib><creatorcontrib>Crooke, Stanley T.</creatorcontrib><creatorcontrib>Veterans Administration Hospital, Minneapolis, MN</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Med. Pediatr. Oncol.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elson, Michael K.</au><au>Oken, Martin M.</au><au>Shafer, Rex B.</au><au>Broughton, Alan</au><au>Strong, James</au><au>Braun, C. T.</au><au>Crooke, Stanley T.</au><aucorp>Veterans Administration Hospital, Minneapolis, MN</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of two radioimmunoassays and a microbiologic assay for bleomycin</atitle><jtitle>Med. Pediatr. Oncol.; (United States)</jtitle><addtitle>Med. Pediatr. Oncol</addtitle><date>1978</date><risdate>1978</risdate><volume>5</volume><issue>1</issue><spage>213</spage><epage>218</epage><pages>213-218</pages><issn>0098-1532</issn><eissn>1096-911X</eissn><abstract>Recently two radioimmunoassays have been independently developed for determination of bleomycin levels. In this study these assays are compared with each other and with a standard microbiologic assay for bleomycin. Bleomycin levels were determined in serum and urine samples obtained at varying intervals following intramuscular bleomycin injection. There were systematic differences between the assays. One radioimmunoassay indicated bleomycin levels lower than the levels indicated by the microbiologic assay with serum samples. With urine samples, both radioimmunoassays indicated bleomycin levels greater than the microbiologic assay.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>85252</pmid><doi>10.1002/mpo.2950050129</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0098-1532 |
| ispartof | Med. Pediatr. Oncol.; (United States), 1978, Vol.5 (1), p.213-218 |
| issn | 0098-1532 1096-911X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74379713 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | 550601 - Medicine- Unsealed Radionuclides in Diagnostics ANTI-INFECTIVE AGENTS ANTIBIOTICS Antibody Specificity ANTIMITOTIC DRUGS ANTINEOPLASTIC DRUGS BIOASSAY Biological Assay BIOLOGICAL MATERIALS BIOLOGICAL WASTES BLEOMYCIN Bleomycin - analysis BLOOD SERUM BODY FLUIDS COBALT ISOTOPES Cobalt Radioisotopes COMPARATIVE EVALUATIONS DRUGS Humans IMMUNE SERUMS IODINE ISOTOPES Iodine Radioisotopes ISOTOPE APPLICATIONS ISOTOPES LABELLED COMPOUNDS MATERIALS microbiologic assay PATIENTS pharmacokinetics RADIOASSAY RADIOIMMUNOASSAY Radioimmunoassay - methods RADIOLOGY AND NUCLEAR MEDICINE Time Factors TRACER TECHNIQUES URINE WASTES |
| title | Comparison of two radioimmunoassays and a microbiologic assay for bleomycin |
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