Hematopoietic Stem Cells In Friend Murine Leukemia Virus-Infected Mice Undergoing Chemotherapy: Remission and Relapse of Erythropoietin-Independent Erythropoiesis Induced by Hydroxyurea

Hydroxyurea (HU), given ip four times, each time at 500 mg/kg in 6-hour Intervals, was used to treat DBA/2 mice with Friend murine leukemia virus-induced polycythemia (F-MuLV-P). In these mice a new cell type, found after virus infection, gave rise to erythropoietic colonies in vitro without additio...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1979-03, Vol.62 (3), p.531-536
Hauptverfasser:	Seidel, H. J., Opitz, Uta
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Survival - drug effects Colony-Forming Units Assay Erythropoiesis - drug effects Erythropoietin - pharmacology Female Friend murine leukemia virus Hematopoietic Stem Cells - drug effects Hydroxyurea - pharmacology Leukemia, Experimental - drug therapy Mice Mice, Inbred DBA Recurrence Remission, Spontaneous
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