Three-Dimensional Structure of a Recombinant Gap Junction Membrane Channel

Gap junction membrane channels mediate electrical and metabolic coupling between adjacent cells. The structure of a recombinant cardiac gap junction channel was determined by electron crystallography at resolutions of 7.5 angstroms in the membrane plane and 21 angstroms in the vertical direction. Th...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1999-02, Vol.283 (5405), p.1176-1180
Hauptverfasser:	Unger, Vinzenz M., Kumar, Nalin M., Gilula, Norton B., Yeager, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Analytical, structural and metabolic biochemistry Animals Binding and carrier proteins Biological and medical sciences Cell Line Connexin 43 - chemistry Connexins Cricetinae Crystal lattices Crystallography Crystals Fundamental and applied biological sciences. Psychology Gap junctions Gap Junctions - chemistry Gap Junctions - ultrastructure Homeostasis Ion channels Lipid Bilayers - chemistry Mathematical lattices Membranes Membranes (Biology) Models, Molecular Molecules Mutation Myocardium - chemistry Myocardium - ultrastructure P branes Protein Conformation Protein Structure, Secondary Proteins Recombinant Proteins - chemistry Science Symmetry
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